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Genetic Consequences of Nucleotide Pool Imbalance

  • Book
  • © 1985

Overview

Editors:
  1. Frederick J. Serres

    1. National Institute of Environmental Health Sciences, USA

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Part of the book series: Basic Life Sciences (BLSC, volume 31)

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-x
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  3. Nucleotide Metabolism

    1. Metabolic Effects of Poly(ADP-Ribose) Inhibitors

      • Kathryn M. Milam, James E. Cleaver
      Pages 25-31

    2. Ribonucleotide Reductase and Deoxyribonucleotide Pools

      • Peter Reichard
      Pages 33-45

    3. Enzymatic Channeling of DNA Precursors

      • Christopher K. Mathews
      Pages 47-66

    4. A Possible Secondary Role for Thymine-Containing DNA Precursors

      • Robert J. Melamede, Susan S. Wallace
      Pages 67-102

    5. Multiple Mechanisms of Adenosine Toxicity in an Adenosine Sensitive Mutant of Baby Hamster Kidney (BHK) Cells

      • Voon-Loong Chan, H. Jeok Ho
      Pages 103-116

  4. DNA Replication Errors Caused by Nucelotide Imbalance

    1. Effects of Altered Nucleotide Concentrations on the Fidelity of DNA Replication

      • Shishir K. Das, Thomas A. Kunkel, Lawrence A. Loeb
      Pages 117-126

    2. Response of CHO Cell DNA Polymerase Alpha to dCTP and dTTP Pool Imbalance: Relation to DNA Synthesis Inhibition, Survival and Mutation

      • C. N. Newman, J. H. Miller
      Pages 127-148

    3. Misincorporation of Deoxyuridine in Human Cells: Consequences of Antifolate Exposure

      • Randall G. Richards, Oliver E. Brown, W. David Sedwick
      Pages 149-162

    4. Effects of Nucleotide Pool Imbalances on the Excision Repair of Ultraviolet-Induced Damage in the DNA of Human Diploid Fibroblasts

      • Ronald D. Snyder
      Pages 163-173

    5. Effect of Variations in the Conditions of DNA Synthesis upon the Accuracy of DNA Replication

      • Tashmeem Razzaki, Navin K. Sinha
      Pages 175-187

  5. Genetic Consequences of Nucleotide Pool Imbalances

    1. Thymineless Mutagenesis in Bacteria

      • Bernard A. Kunz
      Pages 189-209

    2. Genetic and Biochemical Effects of Thymidylate Stress in Yeast

      • J. G. Little
      Pages 211-231

    3. Biological Consequences of Guanine Starvation

      • Wolfgang Sadée, Binh Trong Nguyen
      Pages 233-240

    4. Thymineless Death and Genetic Events in Mammalian Cells

      • Takeshi Seno, Dai Ayusawa, Kimiko Shimizu, Hideki Koyama, Keiichi Takeshi, Tada-aki Hori
      Pages 241-263

    5. Induction of Mitochondrial Mutations in Human Cells by Methotrexate

      • David I. Hoar, Leo S. Dimnik
      Pages 265-282

    6. Induction of Mutation and Chromosome Damage by Excess Bases and Nucleosides

      • Diana Anderson
      Pages 283-295

    7. The Genetic Consequences of the Thy- Mutation to CHO Cells

      • Mark Meuth, Otelinda Gonçalves, Marie Trudel
      Pages 297-312

    8. Deoxyribonucleoside-Induced Selective Modulation of Cytotoxicity and Mutagenesis

      • A. R. Peterson, P. V. Danenberg, L. L. V. Ibric, H. Peterson
      Pages 313-334
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Keywords

About this book

This book is concerned with the genetic consequences of nu­ cleotide pool imbalance. There are a number of ways in which this state can be achieved and the majority of papers in this volume de­ scribe the effects of nucleotide pool imbalance on DNA replication and repair, and the induction of gene mutations in various organisms. This book grew out of a Conference on "Genetic Consequences of Nu­ cleotide Pool Imbalance" which was held at the National Institute of Environmental Health Sciences on May 9-11, 1983. The Organizing Com­ mittee consisted of Drs. Diana Anderson (BIBRA), Robert Haynes (York University), Bernard Kunz (NIEHS), Barry Glickman (NIEHS), and Frederick J. de Serres (NIEHS), Chairman. The meeting was org- ized by the staff of the Office of the Associate Director for Genetics and was financed solely by the National Institute of Environmental Health Sciences. Frederick J. de Serres, Ph.D. Associate Director for Genetics v CONTENTS SECTION I. INTRODUCTION Molecular Mechanisms in Genetic Stability and Change: 1 The Role of Deoxyribonucleotide Pool Balance •••••• Robert H. Haynes SECTION II. NUCLEOTIDE METABOLISM 25 Metabolic Effects of Poly(ADP-ribose) Inhibitors •••••••• Kathryn M. Milam and James E. Cleaver Ribonucleotide Reductase and Deoxyribonucleotide 33 POQ 1 s ............................................ . Peter Reichard 47 Enzymatic Channeling of DNA Precursors •••••••••••••••••• Christopher K. Mathews A Possible Secondary Role for Thymine-Containing DNA 67 Precursors ....................................... . Robert J. Melamede and Susan S. Wallace Multiple Mechanisms of Adenosine Toxicity in an Adenosine Sensitive Mutant of Baby Hamster 103 Kidney (BHK) Cells............................... .

Editors and Affiliations

  • National Institute of Environmental Health Sciences, USA

    Frederick J. Serres

Bibliographic Information

  • Book Title: Genetic Consequences of Nucleotide Pool Imbalance

  • Editors: Frederick J. Serres

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4613-2449-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1985

  • Softcover ISBN: 978-1-4612-9488-7Published: 11 November 2011

  • eBook ISBN: 978-1-4613-2449-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 523

  • Topics: Human Genetics, Cell Biology, Biochemistry, general

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