Human T Cell Clones

1. Front Matter

   Pages i-xv

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2. T Cell Receptor

   1. Front Matter

      Pages 1-2

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   2. Molecular and Functional Analysis of the Human T Cell Antigen/MHC Receptor

      • Oreste Acuto, Marina Fabbi, Ellis L. Reinherz

      Pages 3-14

   3. The Murine T Cell Receptor

      • Kathryn Haskins, Neal Roehm, Charles Hannum, Janice White, Ralph Kubo, Philippa Marrack et al.

      Pages 15-23

   4. The Genes of the Murine T Cell Receptor

      • Nicholas R. J. Gascoigne, Yueh-hsiu Chien, Phillip Patten, Daniel M. Becker, Tullia Lindsten, Joshua Kavaler et al.

      Pages 25-34

   5. Molecular Studies of the Human T-Cell Antigen Receptor

      • Mary K. L. Collins, A. Maija Kissonerghis, M. Jenny Dunne, Michael J. Owen

      Pages 35-46

3. HLA Antigens and Their Recognition

   1. Front Matter

      Pages 47-47

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   2. Cloned HLA-D Genes: Characterisation and Approaches to Expression and Analysis of Function

      • John Trowsdale, Penelope Austin, Susan Carson, Adrian Kelly, Jonathan Lamb, John Young

      Pages 49-57

   3. SB-Specific CTL Clones Exhibit Functional Heterogeneity in their Susceptibility to Blocking by Anti-T3 and Anti-T4 Antibodies

      • William E. Biddison, Stephen Shaw

      Pages 59-69

   4. Recognition of HLA class II Molecules by Functional Human T-Lymphocyte Clones (TLC’s)

      • David D. Eckels

      Pages 71-82

   5. Restriction Elements on Class II HLA Molecules Studied by Cloned Human T4 Cells

      • Erik Qvigstad, Erik Thorsby

      Pages 83-90

   6. Molecular and Functional Analysis of HLA-Class II Molecules Responsible for the Primary MLR in Man

      • T. Sasazuki, Y. Nishimura, K. Tsukamoto, K. Hirayama, T. Sone

      Pages 91-103

   7. HLA-Class I Antigen Recognition by EB Virus-Specific and Allo-Specific Cytotoxic T Cells

      • Lesley E. Wallace, Melanie A. Houghton, Alan B. Rickinson

      Pages 105-114

4. Clones Recognizing Extrinsic Antigens

   1. Front Matter

      Pages 115-116

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   2. Antigen Recognition by Human Influenza Virus Specific Helper T Lymphocyte Clones

      • J. R. Lamb, M. Feldmann, N. Green, R. A. Lerner, E. D. Zanders

      Pages 117-124

   3. Exogenous IL-2 Independent Antigen-Specific Human T Cells: Antigen-Specific Induction of Polyclonal B Cell Factors

      • David J. Volkman, Thomas B. Nutman, Eric A. Ottesen, Anthony S. Fauci

      Pages 125-133

   4. Probing a repertoire of T cells responding to a mycobacterial antigen

      • Ann D. M. Rees, Glenda L. Knott, Paul N. Nelson, Nicola Dobson, Ruth Mathews, Peter W. Andrew

      Pages 135-145

   5. Accessory Cell Requirements for the Proliferation of Antigen Specific Human T Cells

      • Raif S. Geha

      Pages 147-162

   6. Nickel-Specific Human T Cell Clones: Functional Characterization and Requirements for Triggering

      • F. Sinigaglia, D. Scheidegger, A. Lanzavecchia, M. Pletscher, R. J. Scheper, G. Garotta

      Pages 163-170

5. Role of Cell Surface Molecules in T Cell Function

   1. Front Matter

      Pages 171-172

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Most complex biological systems, such as enzyme pathways, are effec­ tively controlled near the beginning of the process. There is increasing evidence that the same is true for the immune system, with the initial interactions between antigen, antigen-presenting cells, and T cells hav­ ing a paramount influence on the ensuing events. Thus, analysis of the early stages of the immune responses has been a preoccupation of many immunologists. This has been considerably aided by the capac­ ity to expand these early events, and 'immortalize' them as clones of T cells, for detailed analysis. The discovery by Morgan, Ruscetti, and Gallo (Science 193, 1007, 1976) of T-cell growth factor (now termed interleukin-2 or IL-2) has had a major impact in immunology that is far from over. The greater ease of handling murine tissues experimentally, with the availability of more precisely defined reagents such as inbred strains, has meant that, to date, most of the work on long-term T-cell cultures has been per­ formed in the mouse, as summarized by Fathman and Fitch (eds. , Iso­ lation, Characterization and Utilization of T Lymphocyte Clones, Aca­ demic Press, NY, 1982). However, the limitations of working with human tissues are counterbalanced by the great long-term importance of understanding disorders of human immune regulation, especially since it is becoming evident that these are far from rare. Immune deficiencies such as agammaglobulinemia and T-cell deficiencies are not common, but immune hyperresponsiveness occurring in allergy and allergiC diseases (e. g.

• AIDS
• Antigen
• autoimmune disease
• interferon
• transplantation

• Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College London, London, UK

  Marc Feldmann

• MRC Tuberculosis and Related Infections, Hammersmith Hosptial, London, UK

  Jonathan R. Lamb

• Tissue Bank, Naval Medical Research Institute, Bethesda, USA

  James N. Woody

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