Structure, Function, and Genetics of Ribosomes

1. Front Matter

   Pages i-xxii

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2. Structure of Ribosomes

   • H. G. Wittmann

   Pages 1-27

3. Immuno Electron Microscopy on Escherichia coli Ribosomes

   • G. Stöffler, M. Stöffler-Meilicke

   Pages 28-46

4. Ribosome Structure, Function, and Evolution: Mapping Ribosomal RNA, Proteins, and Functional Sites in Three Dimensions

   • M. Oakes, E. Henderson, A. Scheinman, M. Clark, J. A. Lake

   Pages 47-67

5. Structure of Ribosomes and Their Components by Advanced Techniques of Electron Microscopy and Computer Image Analysis

   • M. Boublik, G. T. Oostergetel, J. S. Wall, J. F. Hainfeld, M. Radermacher, T. Wagenknecht et al.

   Pages 68-86

6. A 19 Protein Map of the 30S Ribosomal Subunit of Escherichia coli

   • P. B. Moore, M. Capel, M. Kjeldgaard, D. M. Engelman

   Pages 87-100

7. Neutron-Scattering Analysis of Structural and Functional Aspects of the Ribosome: The Strategy of the Glassy Ribosome

   • V. Nowotny, R. P. May, K. H. Nierhaus

   Pages 101-111

8. Studies on Crystals of Intact Bacterial Ribosomal Particles

   • A. Yonath, M. A. Saper, H. G. Wittmann

   Pages 112-127

9. Self-Organization of Ribosomal RNA

   • V. D. Vasiliev, I. N. Serdyuk, A. T. Gudkov, A. S. Spirin

   Pages 128-142

10. Studies on the Structure and Function of Ribosomal RNA

    • H. F. Noller, M. Asire, A. Barta, S. Douthwaite, T. Goldstein, R. R. Gutell et al.

    Pages 143-163

11. Comparative Structural and Functional Studies on Small Ribosomal RNAs

    • V. A. Erdmann, T. Pieler, J. Wolters, M. Digweed, D. Vogel, R. Hartmann

    Pages 164-183

12. RNA Structure and RNA-Protein Neighborhoods in the Ribosome

    • R. Brimacombe, J. Atmadja, A. Kyriatsoulis, W. Stiege

    Pages 184-202

13. RNA Structure in Solution and on the 30S Ribosomal Subunit

    • C. R. Cantor, C.-F. Hui, C. Kang, C. L. Smith, P. L. Wollenzien

    Pages 203-216

14. The Folding of RNA in the 30S Subunit of Escherichia coli Ribosomes

    • P. Spitnik-Elson, D. Elson

    Pages 217-232

15. Probing Ribosomal Structure and Function

    • W. E. Hill, W. E. Tapprich, A. Tassanakajohn

    Pages 233-252

16. How Do Protein L18 and 5S RNA Interact?

    • J. Christiansen, R. A. Garrett

    Pages 253-269

17. Structure and Interactions of Ribosomal Components and Ligands

    • J.-P. Ebel, B. Ehresmann, C. Ehresmann, M. Mougel, R. Giegé, D. Moras

    Pages 270-285

18. Protein Topography of Ribosomal Functional Domains: Effects of Monoclonal Antibodies to Different Epitopes in Escherichia coli Protein L7/L12 on Ribosome Function and Structure

    • R. R. Traut, D. S. Tewari, A. Sommer, G. R. Gavino, H. M. Olson, D. G. Glitz

    Pages 286-308

19. On the Structure, Function, and Dynamics of L7/L12 from Escherichia coliRibosomes

    • W. Möller, J. A. Maassen

    Pages 309-325

20. Ribosomal Proteins: Their Structure and Evolution

    • B. Wittmann-Liebold

    Pages 326-361

During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was transmitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramati­ cally different. We have an almost bewildering variety of information de­ tailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for replicating, distributing, and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids, and smaller mole­ cules work together to provide the molecular setting of living systems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of mono­ graphs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field.

• Monoclonal Antibodies
• RNA
• biology
• electron microscopy
• escherichia coli
• gene expression
• genetics
• molecular biology
• molecular mechanisms
• nucleic acid
• protein
• protein synthesis
• proteins
• regulation
• translation

• Clayton Foundation Biochemical Institute Department of Chemistry, The University of Texas at Austin, Austin, USA

  Boyd Hardesty, Gisela Kramer

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