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Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy

  • Book
  • © 1986

Overview

Editors:
  1. C. Julian Rosenthal

    1. Division of Medical Oncology, State University of New York Health Science Center at Brooklyn, Brooklyn, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Marvin Rotman

    1. Department of Radiation Oncology, State University of New York Health Science Center of Brooklyn, Brooklyn, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Protracted Administration of Antineoplastic Chemotherapy Agents

    1. Front Matter

      Pages 1-1
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    2. Principles and Therapeutic Applications

      1. Theoretical, Clinical, and Pharmacokinetic Aspects of Cancer Chemotherapy Administered by Continuous Infusion
        • Branimir Ivan Sikic
        Pages 3-12
      2. Pharmocology and Therapeutic Efficacy of Bleomycin Administered By Continuous Infusion
        • Irwin H. Krakoff
        Pages 13-17
      3. Continuous-Infusion Adriamycin
        • Robert S. Benjamin, Sant P. Chawla, Gabriel N. Hortobagyi, Michael S. Ewer, Bruce Mackay, Sewa S. Legha et al.
        Pages 19-25
      4. 5-Fluorouracil Plus Thymidine or Leucovorin by Continuous I.V. Infusion in the Treatment of Advanced Colorectal Carcinoma
        • Fabio Trave, Youcef M. Rustum
        Pages 27-42
      5. Epipodophyllotoxin and Cisplatin on Continuous Infusion Schedules
        • Jacob J. Lokich
        Pages 43-50
      6. Biodegradable Starch Microspheres (Spherex), a Clinically Useful Medical Device for Combined Intra-Arterial Chemotherapeutic Treatment of Primary and Metastatic Cancers of the Liver: The Potential Clinical Value for Spherex in Regionalized Immunotherapy, Hyperthermia and Radiation Protection
        • George Parker, William Regelson
        Pages 51-66
      7. Selective Therapy of Hepatic Cancers Using Microspheres
        • John W. Gyves
        Pages 67-69

    3. Clinical Studies

      1. Preliminary Results of a Randomized Study of Intrahepatic Infusion versus Systemic Infusion of FUDR for Metastatic Colorectal Carcinoma
        • Nancy Kemeny, John Daly
        Pages 73-78
      2. COPBLAM: Infusion Chemotherapy for Large Cell Lymphoma
        • Morton Coleman, D. Barry Boyd, Bernard Bernhardt, Gary Gerstein, Samuel Kopel
        Pages 79-86
      3. Adriamycin Continuous I.V. Infusion for the Treatment of Childhood Hepatic Malignancies, Toxicity, and Efficacy: A Pilot Study Childrens Cancer Study Group, Los Angeles, California
        • Jorge A. Ortega, Williams Woods, James Feusner, Gregory Reaman, Beverly Lange, G. Denman Hammond
        Pages 87-90
      4. An Uncontrolled Phase II Study of Constant Infusion Vincristine-Adriamycin
        • L. Helson, M. A. Castello, E. Arenson, L. Steinherz, S. Groshen
        Pages 91-94
      5. Low-Dose Ara-C by Continuous Infusion in the Treatment of Acute Non-Lymphocytic Leukemia (ANLL) and Myelodysplastic Syndrome (MDS)
        • Farida Chaudhri, Steven L. Allen, Philip Schulman, Willi Kreis, Daniel R. Budman, Lora Weiselberg et al.
        Pages 95-100
      6. The 5-Day Continuous Infusion of Cis-Platinum: An Update on Toxicity Pattern
        • P. Salem, M. Khalyl, K. Jabboury, L. Hashimi
        Pages 101-105
      7. Long Term Appraisal of the Lemon-Foley Method of Chemotherapy of Solid Tumors of the Gastrointestinal Tract
        • Donald Steinberg
        Pages 107-110

  3. Antineoplastic Effects of Radiation Therapy and Chemothrapy by Continuous Unfusion

    1. Front Matter

      Pages 111-111
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    2. Principles and Therapeutic Applications

      1. Theoretical Basis and Clinical Applications of 5-Fluorouracil as a Radiosensitizer
        • John E. Byfield
        Pages 113-125
      2. Treatment of Hepatic Metastases from Gastrointestinal Primaries with Split Course Radiation Therapy and Concomitant Infusion 5-Fluorouracil
        • M. Rotman, I. Bhutiani, A. Kuruvilla, K. Choi, J. Rosenthal, A. Braverman et al.
        Pages 127-132
      3. Combined Modality Therapy With 5-Fluorouracil, Mitomycin C and Radiation Therapy for Squamous Cell Cancers
        • B. J. Cummings, T. J. Keane, A. R. Harwood, G. M. Thomas
        Pages 133-147
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Keywords

About this book

The first conference on concomitant infusion chemotherapy and radia­ tion therapy was organized with the intention of bringing together some of the investigators who have tested, during the last few years, the hypo­ thesis that continuous infusion chemotherapy could modulate the cytotoxic effect of radiation therapy to the point of having a strongly additive, if not synergistic activity on certain malignant tumors. This volume represents the detailed proceedings of this conference presented in a way that offers the reader a review of the on-going re­ search in the field. We have stressed a number of subjects from basic biologic research and influence of cell kinetics to the practical methods of drug delivery systems and early clinical experiences. The rationale for this new type of combined modality therapy has been presented by some of its pioneers. Early clinical investigations as well as the preliminary data of many that have not yet completely matured have also been included. The reader should look at these data with some reser­ vations. Ultimately, these results must be confirmed by larger prospective randomized studies with proper controls before becoming accepted as the treatment of choice in locally advanced tumors.

Editors and Affiliations

  • Division of Medical Oncology, State University of New York Health Science Center at Brooklyn, Brooklyn, USA

    C. Julian Rosenthal

  • Department of Radiation Oncology, State University of New York Health Science Center of Brooklyn, Brooklyn, USA

    Marvin Rotman

Bibliographic Information

  • Book Title: Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy

  • Editors: C. Julian Rosenthal, Marvin Rotman

  • DOI: https://doi.org/10.1007/978-1-4613-2197-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1986

  • Softcover ISBN: 978-1-4612-9291-3Published: 25 April 2013

  • eBook ISBN: 978-1-4613-2197-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 248

  • Topics: Computer Applications in Chemistry

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