The Cytoskeleton

1. Front Matter

   Pages I-XIV

   PDF

2. Overview

   1. Structure and Function of the Cytoskeleton

      • Polly R. Sager, Tore L. M. Syversen, Thomas W. Clarkson, John B. Cavanagh, Arnljot Elgsaeter, Hans Cato Guldberg et al.

      Pages 3-21

   2. The Cytoskeleton as a Target For Toxic Agents

      • Tore L. M. Syversen, Polly R. Sager, Thomas W. Clarkson, John B. Cavanagh, Anljot Elgsaeter, Hans Cato Guldberg et al.

      Pages 25-34

3. Invited Papers

   1. Microtubules and Microtubule Inhibitors

      1. Microtubules as Targets for Drug and Toxic Chemical Action: The Mechanisms of Action of Colchicine and Vinblastine

         • Leslie Wilson

         Pages 37-52

      2. Taxol: A Probe for Studying the Structure and Function of Microtubules

         • Susan B. Horwitz, Peter B. Schiff, Jerome Parness, James J. Manfredi, Wilfredo Mellado, Samar N. Roy

         Pages 53-65

      3. Reorganization of Axonal Cytoskeleton Following β, β′-Iminodipropionitrile (IDPN) Intoxication

         • Sozos Ch. Papasozomenos

         Pages 67-82

      4. Molecular and Cellular Aspects of the Interaction of Benzimidazole Carbamate Pesticides with Microtubules

         • Edward H. Byard, Keith Gull

         Pages 83-96

      5. Disruption of Microtubules by Methylmercury

         • Polly R. Sager, Tore L. M. Syversen

         Pages 97-116

   2. Cytoskeleton of the Nervous System

      1. Primary and Secondary Changes in Axonal Transport in Neurofibrillary Disorders

         • Bruce G. Gold, John W. Griffin, Donald L. Price, Paul N. Hoffman

         Pages 119-127

      2. Chemical Neurotoxins Accelerating Axonal Transport of Neurofilaments

         • Pierluigi Gambetti, Salvatore Monaco, Lucila Autilio-Gambetti, Lawrence M. Sayre

         Pages 129-142

      3. The Effect of Some Dithiocarbamates, Disulfiram and 2,5-Hexanedione on the Cytoskeleton of Neuronal Cells <u>in</u> <u>Vivo</u> and <u>in</u> <u>Vitro</u>

         • Veli-Pekka Lehto, Ismo Virtanen, Kai Savolainen

         Pages 143-158

      4. Neurofibrillary Degeneration: The Role of Aluminum

         • Michael L. Shelanski

         Pages 159-166

      5. Pathogenetic Studies of the Neurofilamentous Neuropathies

         • Doyle G. Graham, Gyöngyi Szakàl-Quin, Leslie Milam, Marcia R. Gottfried, D. Carter Anthony

         Pages 167-174

   3. Cytoskeleton and Membrane Related Events

      1. Effects of Calcium on Structure and Function of the Human Red Blood Cell Membrane

         • Hermann Passow, Melanie Shields, Paul La Celle, Ryszard Grygorczyk, Wolfgang Schwarz, Reiner Peters

         Pages 177-186

      2. Spectrin and the Mechanochemical Properties of the Erythrocyte Membrane

         • Arnljot Elgsaeter, Arne Mikkelsen, Bjørn T. Stokke

         Pages 187-197

      3. Effects of Local Anesthetics and pH Change on the Platelet “Cytoskeleton” and on Platelet Activation

         • Vivianne T. Nachmias, Robert M. Leven

         Pages 199-211

      4. Inhibition of Motility by Inactivated Myosin Heads

         • Robin Jones, Michael Sheetz

         Pages 213-220

      5. Intracellular Translocation of Inorganic Particles

         • Arnold R. Brody, Lila H. Hill, Thomas W. Hesterberg, J. Carl Barrett, Kenneth B. Adler

         Pages 221-227

      6. Receptor Cycling in Pituitary Cells: Biological Consequences of Inhibition of Receptor-Mediated Endocytosis

         • Patricia M. Hinkle, Jane Halpern, Patricia A. Kinsella, Risa A. Freedman

         Pages 229-242

4. Conference Summary

   1. Conference Summary

      • N. Karle Mottet

      Pages 243-251

This book is based on reviews and research presentations given at the 16th Rochester International Conference on Environmental Toxicity, entitled liThe Cytoskeleton: A Target for Toxic Agents," held on June 4, 5 and 6 in 1984. The conference provided an in-depth discussion of the effects a~d mechanism of action of some toxic agents on the cytoskeleton. Mamma"lian and other eukaryotic cells contain protein networks within the cytoplasm comprised of microfilaments, intermediate Hlaments and microtubules. These components of the cytoskeleton playa key role in cell shape, motility, intracellular organization and transport, and cell division. Furthermore, the cytoskeleton, via associations with the cell membrane, appears to function in intracellular communication and cellular responses to membrane events. Because of the complex functional roles of the cytoskeleton which vary with cell type, degree of differentiation, and cell cycle, its disruption may result in a variety of cellular changes. This expanding field in cell biology has already attracted the interest of toxicologists and environmental health scientists as a potentially fruitful area of research. Indeed, there is mounting evidence that certain toxic and chemotherapeutic compounds, as well as physical agents such as radiation and hydrostatic pressure, disrupt the normal structure and function of the cytoskeleton. This may be an important step in the overall expression of their action. It was, therefore, an opportune time to hold a conference to encourage the development of this area of toxicology and to suggest directions for future research.

• Calcium
• Pathogene
• cell biology
• drug
• environment
• health
• mercury
• pesticide
• pesticides
• research
• toxicity
• toxicology
• toxin
• transport

• University of Rochester School of Medicine, Rochester, USA

  Thomas W. Clarkson

• University of Connecticut Health Center, Farmington, USA

  Polly R. Sager

• University of Trondheim Faculty of Medicine, Trondheim, Norway

  Tore L. M. Syversen

Policies and ethics