Pathophysiology of Heart Disease

1. Front Matter

   Pages i-xiv

   PDF

2. Presidential Address

   1. Front Matter

      Pages 1-1

      PDF

   2. Role of the Basic Sciences in the Practice of Cardiology

      • Arnold M. Katz

      Pages 3-35

3. Myocardial Hypertrophy

   1. Front Matter

      Pages 37-37

      PDF

   2. Physiological and Pathological Hypertrophy

      • R. Jacob, M. Vogt, H. Rupp

      Pages 39-56

   3. Potential Role of Catecholamines in the Production of Physiological and Pathological Hypertrophy

      • Michael M. Laks

      Pages 57-72

   4. Role of Thyroid Hormone in the Regulation of Cardiac Hypertrophy

      • Irwin Klein, Chull Hong

      Pages 73-81

   5. Oxygen Sources and Sinks in Myocardial Hypertrophy

      • K. Rakusan, Z. Turek

      Pages 83-92

   6. Stretch, a Common Denominator in Muscle Growth

      • Howard E. Morgan, Ellen E. Gordon, Balvin H. L. Chua, Louise A. Russo, Xenophon P. Xenophontos

      Pages 93-98

   7. The Quantity and Rate of Calcium Uptake in Normal and Hypertrophied Hearts

      • Norman R. Alpert, Edward M. Blanchard, Louis A. Mulieri

      Pages 99-111

4. Hypertension and Heart Failure

   1. Front Matter

      Pages 113-113

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   2. Implications of Atrial Natriuretic Factor (ANF) in the Pathogenesis of Experimental and Human Hypertension

      • M. Cantin, R. Garcia, J. Gutkowska, G. Thibault, O. Kuchel, P. Larochelle et al.

      Pages 115-130

   3. Plasma Concentration of Atrial Natriuretic Factor in Congestive Heart Failure

      • K. Ogawa, T. Ito, H. Hashimoto, T. Satake

      Pages 131-142

   4. Mechanisms of Vasoconstriction in Hypertension and Chronic Congestive Heart Failure

      • Robert J. Cody

      Pages 143-150

   5. Possible Adverse Effects of Catecholamines in Congestive Heart Failure: A Rationale for Beta-Blocker Therapy

      • Michael J. Sole

      Pages 151-161

5. Heart Disease in Diabetes

   1. Front Matter

      Pages 163-163

      PDF

   2. Cardiac Dysfunction in the Diabetic Heart

      • John H. McNeill, Rao V. S. V. Vadlamudi, Brian Rodrigues

      Pages 165-176

   3. The Association of Membrane Alterations with Heart Dysfunction During Experimental Diabetes Mellitus

      • G. N. Pierce, N. S. Dhalla

      Pages 177-184

   4. Abnormalities in Contractile Proteins in Myocardium from Chronic Diabetic Animals

      • J. Scheuer, P. S. Pollack, A. Malhotra

      Pages 185-198

   5. Energy Metabolism in Diabetic Heart

      • N. Haugaard, M. E. Hess, A. Torbati, O. L. Tulp

      Pages 199-208

It is indeed ironical that in the absence of a complete knowledge of Pathophysiology, clinical cardiologists are left with no choice but to do the best they can to help the patient with the armamentarium of drugs at their disposal. But nothing could be further from truth than to treat the diagnosed end point of a disease process without a full understanding of its patho­ physiology. This point was eloquently made by Dr. Arnold Katz in his Presidential Address (Chapter 1) at the 8th Annual Meeting of the American Section of the International Society for Heart Research held in Winnipeg, Canada, July 8-11, 1986. This volume represents a part of the scientific proceedings of this Meeting. From a reading of this treatise it will become evident that discoveries of newer scientific facts as well as a better understanding of pathophysiology are continuously influencing/ improving our therapeutic approaches in modern medicine. In this book, latest biochemical, physiological and pharmacological findings on different experimental models such as Myocaridal hypertrophy, Hypertension and heart failure, Diabetes, Cardio­ myopathies and Cardiac function in shock are described by internationally recognised experts. Hopefully information presented here will provide another building block to the edifice of Science of Cardiology which we all are trying to create. Acknowledgements We are grateful to the following Agencies and Foundations for their generous financial support of the Symposium, which formed the basis of this book. A. Major Contributors: 1. Manitoba Heart Foundation 2. Sterling-Winthrop Research Institute 3. Squibb Canada, Inc.

• cardiac function
• cardiology
• drugs
• heart
• heart disease
• heart failure
• hypertension
• physiology

• Department of Physiology, Youville Research Institute, St. Boniface General Hospital and University of Manitoba, Winnipeg, Canada

  Naranjan S. Dhalla, Pawan K. Singal, Robert E. Beamish

Policies and ethics