Fundamental Problems in Breast Cancer

1. Front Matter

   Pages i-xviii

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2. The Natural History and Clinical Significance of Breast Cancer Detected by Imaging Techniques

   1. Front Matter

      Pages 1-1

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   2. Pathology of Breast Cancer Detected by Imaging Techniques

      • Harold A. Oberman

      Pages 3-10

   3. Screening for Breast Cancer: An Overview

      • Laszlo Tabar

      Pages 11-16

   4. Research in New Imaging Methods for Detection of Breast Cancer

      • M. J. Yaffe, R. M. Nishikawa, A. Fenster

      Pages 17-24

   5. The Canadian National Breast Screening Study: Current Status

      • Cornelia J. Baines

      Pages 25-27

   6. Natural History of Mammary Tumors Seen in a Breast Center

      • Roger Ghys

      Pages 29-37

   7. An Educational and Diagnostic Breast Center in Edmonton: A Preliminary Report of the First Year

      • P. E. Burns, A. E. Nett

      Pages 39-46

   8. The Breast Center—A Multidisciplinary Model

      • Melvin J. Silverstein, Neal Handel, Robert S. Hoffman, James R. Waisman, Robert J. Rosser, Parvis Gamagami et al.

      Pages 47-57

   9. Multimodality Breast Imaging: The Value of Diaphanography

      • W. R. Castor, F. I. Jackson, T. Hunt

      Pages 59-68

   10. Comparative Value of Diaphanoscopy Mammography, and Thermography for Breast Cancer Screening

       • Roger Ghys

       Pages 69-73

   11. Finding Earlier Nonpalpable Breast Cancers Using Hooked Wire Directed Biopsy and a Modified Overpenetrated Mammographic Technique

       • Melvin J. Silverstein, Parvis Gamagami, Robert J. Rosser, Eugene D. Gierson, William J. Colburn, Neal Handel et al.

       Pages 75-89

   12. The Significance of Tumor Size in Stage I Invasive Breast Cancer

       • Catherine E. de Metz, Arthur T. Porter

       Pages 91-95

   13. The Impact of Breast Cancer Screening on Surgical Treatment Policies

       • Lars Holmberg

       Pages 97-104

   14. Survival of Patients with Breast Cancer Detected Between Mammographic Screenings

       • L. Holmberg, L. Tabar, H. O. Adami, R. Bergström

       Pages 105-111

   15. Intraductal Breast Carcinoma—What Constitutes Adequate Treatment?

       • R. J. Rosser, M. J. Silverstein, E. D. Gierson, P. Gamagami, W. J. Colburn, N. Handel et al.

       Pages 113-124

3. Aspects of the Growth and Mechanism of Response of Endocrine Sensitive Breast Cancer

   1. Front Matter

      Pages 125-125

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   2. Endocrine and other Influences in the Normal Development of the Breast

      • G. Shyamala

      Pages 127-137

   3. Endocrine Prevention of Breast Cancer by Tamoxifen

      • Trevor Powles

      Pages 139-143

   4. Mechanisms of Regression and Revised Approaches to Endocrine Therapy

      • Basil A. Stoll

      Pages 145-153

The chapters in this book are those presented at the Second International Symposium on Fundamental Problems in Breast Cancer held at Banff, Alberta, April 26-29, 1986. This is, therefore, the second volume in the series of symposia held in the Canadian Rockies. The aim of these symposia is to provide a supportive atmosphere for the development of new concepts as well as for the presentation of high quality scientific data. This is reflected in the chapters presented here. Many of the chapters put forward new hypotheses which will be tested in the clinic or laboratory in the next few years. In choosing the subjects for discourse, we preferred to tackle areas where controversy existed, and in this book we have grouped the chapters around discussion themes. The relative merits of mammography and physical examination in the detection of small lesions within the breast and the natural history of these lesions were important topics at the symposium, and the results of early detection studies will have a major effect on health care costs. We have devoted a large section of this book to this subject. The mechanism of growth and response of endocrine sensitive tumors and current concepts of the statistics and cost-benefit assessment of adjuvant chemotherapy trials comprise two other sections of the book where original and stimulating ideas were presented.

• Cancer Screening
• biopsy
• carcinoma
• imaging
• imaging techniques
• systemic therapy

• Breast Unit, Cross Cancer Institute, Edmonton, Canada

  Alexander H. G. Paterson, Alan W. Lees

Policies and ethics