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Oxygen Radicals in the Pathophysiology of Heart Disease

  • Book
  • © 1988

Overview

Editors:
  1. Pawan K. Singal

    1. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Center, Winnipeg, Canada
      Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 86)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. The Biology of Oxygen Radicals: Threats and Defenses

    • Irwin Fridovich
    Pages 1-11

  3. Biological Systems Which Suppress Lipid Peroxidation

    • Paul B. McCay, Edward K. Lai, Donald D. Gibson, J. Lee Poyer, Saul R. Powell, Gemma Brueggemann
    Pages 13-24

  4. Contrasting Features of Peroxide Metabolism in Heart and Liver

    • D. L. Tribble, F. G. Kennedy, D. P. Jones
    Pages 25-40

  5. Free Radical and Iron-Mediated Injury in Lysosomes

    • I. T. Mak, W. B. Weglicki
    Pages 41-53

  6. Myocardial Effects of Partially Reduced Forms of Oxygen

    • M. Gupta, K. K. Gupta, P. K. Singal
    Pages 55-70

  7. Oxygen Radical Mediated Protein Oxidation in Heart

    • H. Fliss, M. Masika, D. W. Eley, B. Korecky
    Pages 71-90

  8. Cardiac Defense Mechanisms against Oxidative Damage: The Role of Superoxide Dismutase and Glutathione-Related Enzymes

    • Toshihisa Ishikawa
    Pages 91-109

  9. The Role of Oxygen Free Radicals during the Course of Myocardial Ischemia/Reperfusion Injury: An Analysis and Critique

    • M. L. Hess, T. D. Greenfield, N. H. Manson, Eiichiro Okabe
    Pages 111-122

  10. The Role of the Polymorphonuclear Leukocyte in Mediating Myocardial Reperfusion Injury

    • Steven W. Werns, Benedict R. Lucchesi
    Pages 123-144

  11. Alterations of Glutathione Status during Myocardial Ischaemia and Reperfusion

    • R. Ferrari, S. Curello, C. Ceconi, A. Cargnoni, E. Condorelli, A. Albertini
    Pages 145-160

  12. Alterations in Membrane Phospholipids, Mechanisms of Free Radical Damage and Antioxidant Protection during Myocardial Ischemia and Reperfusion

    • Karen P. Burton, Kenneth D. Massey
    Pages 161-176

  13. The Measurement of Conjugated Dienes in Ischemic and Reperfused Myocardium

    • Alexander D. Romaschin, Donald A. G. Mickle
    Pages 177-188

  14. Xanthine Oxidase is not Likely to be a Source of Injurious Free Radicals in the Ischemic Human Heart: A Study of Species Differences

    • James M. Downey, Lynne J. Eddy, Chiaki Shirato, Patricia Molina, Miguel Molina
    Pages 189-202

  15. Role of Oxy-Radicals in Postischemic Myocardial Dysfunction

    • Roberto Bolli, Robert Roberts
    Pages 203-225

  16. Acute Effects of Antioxidants on in Vivo Models of Experimental Myocardial Ischemia and Infarction

    • Karin Przyklenk, Robert A. Kloner
    Pages 227-237

  17. Do Free Radicals Contribute to the Genesis of Reperfusion-Induced Arrhythmias?

    • Allan S. Manning, Renata Crome
    Pages 239-259

  18. Importance of Electron Transfer through Allopurinol in Protection from Reperfusion Injury

    • D. A. Peterson, J. M. Gerrard
    Pages 261-269

  19. Role of Antioxidants in Hypoxia-Reoxygenation Injury in the Heart and in Cardiac Myocytes

    • C. Guarnieri, C. Muscari, A. Fraticelli, C. M. Caldarera
    Pages 271-283

  20. The Role of Lipid Peroxidation in the Myocardium in Stress and Antioxidant Protection of the Heart

    • F. Z. Meerson
    Pages 285-301
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Keywords

About this book

Over two centuries ago, oxygen was discovered as "air vital": the component of the earth's atmosphere necessary for life. Less than five years after this discovery, it was found that oxygen was both a life-sustaining and life threatening inhalant as it plays a role in the two extremes of the animal kingdom: life and death. In the subse­ quent years, we have made major strides in understanding the role of oxygen in maintaining life and volumes of information are now available on this topic. Our knowledge of the contribution of oxygen in cellular dysfunction and cell death which for the most part had lagged behind has begun to catch up. The deleterious ef­ fects of oxygen radicals and activated oxygen species on a variety of biological systems have now been described. Recently attention has also been focused on the toxic effects of oxygen on the cardiovascular system. The major aim of the present treatise is to offer an integrated view of the pathophysiological aspects of oxygen toxicity in the heart and blood vessels coupled with a review of therapeutic approaches (hopes?) with free radical scavengers and antioxidants. Internationally known expert investigators provide a concise and critical review on the topic of their expertise which also contains data from their own research.

Editors and Affiliations

  • Division of Cardiovascular Sciences, St. Boniface General Hospital Research Center, Winnipeg, Canada

    Pawan K. Singal

  • Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Pawan K. Singal

Bibliographic Information

  • Book Title: Oxygen Radicals in the Pathophysiology of Heart Disease

  • Editors: Pawan K. Singal

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4613-1743-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1988

  • Hardcover ISBN: 978-0-89838-375-1Published: 31 March 1988

  • Softcover ISBN: 978-1-4612-8979-1Published: 05 October 2011

  • eBook ISBN: 978-1-4613-1743-2Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XIV, 348

  • Topics: Cardiology, Cardiac Surgery, Pharmacology/Toxicology

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