Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

Biochemistry of Platinum Complexes in Cancer Chemotherapy

1. Front Matter

   Pages 1-1

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2. Kinetics of Formation of Genotoxic Platinum-DNA Lesions in Vivo

   • N. P. Johnson, P. Lapetoule, H. Razaka, J. L. Butour

   Pages 3-15

3. The Role of Platinum-DNA Interactions in the Cellular Toxicity and Anti-Tumour Effects of Platinum Co-Ordination Compounds

   • J. J. Roberts, R. J. Knox, M. F. Pera, F. Friedlos, D. A. Lydall

   Pages 16-31

4. In Vivo Cis-Diamminedichloroplatinum(II)-DNA Adduct Formation and Removal as Measured with Immunochemical Techniques

   • A. M. J. Fichtinger-Schepman, F. J. Dijt, W. H. De Jong, A. T. Van Oosterom, F. Berends

   Pages 32-46

5. Oligonucleotide Modelling of Cis-Platinum Binding to DNA

   • J. C. Chottard

   Pages 47-61

6. Macromolecular Antitumor Drugs: Pharmacology and Biology

   • J. Drobnik

   Pages 62-66

7. Unusual Hairpin-Like Conformations of Oligonucleotides Induced by Platinum Anti-Cancer Drugs

   • L. G. Marzilli, C. Spellmeyer Fouts, T. Page Kline, G. Zon

   Pages 67-73

8. Cisplatin-Radiation Interactions in Tumours and Normal Tissues

   • A. C. Begg, F. A. Stewart, L. Dewit, H. Bartelink

   Pages 74-80

9. Linkage Isomers of Platinum Complexes of ANT (2-amino-5-nitrothiazole) Differ in their DNA-Binding and Radiosensitization

   • N. P. Farrell, K. A. Skov

   Pages 81-82

10. Competition between DNA and Orthophosphate for Coordination with Platinum(II) Complexes

    • E. Holler

    Pages 83-88

11. Effect of Cis-Diamminedichloroplatinum(II) on the Nucleotide Pool of Treated P388 Leukemia Cells

    • G. Just, E. Holler

    Pages 89-98

12. Platinum Cytostatics Design Method Based on Topological Indices

    • F. Kiss, P. Tvarůžek, E. Hladká

    Pages 99-101

13. Kinetics of Changes in the Secondary Structure of DNA Induced by the Binding of Platinum Cytostatics

    • V. Kleinwächter, O. Vrána, V. Brabec, N. P. Johnson

    Pages 102-109

14. The Influence of the 3’-Base on the Kinetics of the Binding of [PtCl(dien)]Cl to the Dinucleotides d(GpH) (H = A,C,T)

    • E. L. M. Lempers, K. Inagaki, J. Reedijk

    Pages 110-114

15. In Vitro Repair of Cisplatin-Dna Adducts by a Defined Enzyme System

    • J. D. Page, I. Husain, S. G. Chaney, A. Sancar

    Pages 115-126

16. Importance of DNA Sequence in the Reaction of d(ApG) and d(GpA) with Cis-Diamminedichloroplatinum (II)

    • A. Rahmouni, A. Schwartz, M. Leng

    Pages 127-131

17. Changes in UV-Absorbance are Due to Slow and Fast Conformational Rearrangements during DNA-Platination

    • W. Schaller, E. Holler

    Pages 132-138

18. Visualization of Cisplatin-DNA and Carboplatin-DNA Adducts in Tissues and Cultured Cells

    • P. Terheggen, A. C. Begg, B. Floot, J. Emondt, L. Den Engelse

    Pages 139-143

19. Qualitative Investigation, Both in Vivo and in Vitro, of the Metabolites Formed by Cisplatin and Paraplatin Involving High Performance Liquid Chromatography Analysis

    • N. D. Tinker, H. L. Sharma, C. A. McAuliffe

    Pages 144-159