Clinical and Molecular Aspects of Neurotropic Virus Infection

1. Front Matter

   Pages i-xv

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2. Alphaviruses

   • D. W. Trent, J. T. Roehrig, T. F. Tsai

   Pages 1-41

3. California Serogroup Viruses

   • Francisco Gonzalez-Scarano, Neal Nathanson

   Pages 43-68

4. Flaviviruses

   • M. Brinton

   Pages 69-99

5. Coronaviruses

   • Ehud Lavi, Susan R. Weiss

   Pages 101-139

6. Lymphocytic Choriomeningitis Virus

   • Daniel C. Pevear, Charles J. Pfau

   Pages 141-172

7. Influenza Virus and Reye’s Syndrome

   • Larry E. Davis

   Pages 173-202

8. Measles

   • T. R. Moench, R. T. Johnson

   Pages 203-229

9. Mumps Virus: Molecular Aspects and Its Effects on the Central Nervous System

   • M. Neal Waxham

   Pages 231-243

10. Picornaviruses

    • Miriam Calenoff, Burk Jubelt, Howard L. Lipton

    Pages 245-268

11. Clinical and Molecular Aspects of Rabies Virus Infections of the Nervous System

    • W. H. Wunner, H. Koprowski

    Pages 269-302

12. Rubella Virus and Central Nervous System Disease

    • Betty L. Slagle, Jerry S. Wolinsky

    Pages 303-318

13. Papovavirus Infections of the Nervous System

    • John E. Greenlee

    Pages 319-342

14. Herpes Simplex Virus Infections of the Nervous System

    • William G. Stroop, J. Richard Baringer

    Pages 343-367

15. Clinical and Virologic Aspects of Varicella-Zoster Virus Infection

    • Abbas Vafai, Donald H. Gilden, Zofia Wroblewska

    Pages 369-391

16. The Pathogenesis of Visna, a Lentivirus Induced Immunopathologic Disease of the Central Nervous System

    • P. G. E. Kennedy, O. Narayan, M. C. Zink, Jay Hess, J. Clements, R. J. Adams

    Pages 393-421

17. Human Slow Infections Caused by Prions

    • Stanley B. Prusiner, Karen K. Hsiao, Dale E. Bredesen, David T. Kingsbury

    Pages 423-467

18. The Immune Response to Viruses

    • Henry F. McFarland, Steven Jacobson

    Pages 469-499

19. Postinfectious and Postvaccinal Encephalomyelitis

    • Diane E. Griffin, Thiravat Hemachudha, Richard T. Johnson

    Pages 501-527

20. Back Matter

    Pages 529-543

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In the summer of 1984, both of us were working with Professor Yechiel Becker in the Laboratory for Molecular Virology at the Hebrew University-Hadassah Medical center in Jerusalem. During a discussion about the increasing number of specialized journals and monographs, Dr. Becker pointed out that none covered both the clinical and molecular aspects of neurotropic virus infections, and he urged us to develop such a book with the help of colleagues who were conducting highly-regarded research in their individual areas related to neurotropic viruses. The responses to our request were gratifying, and each contribution provided both a comprehensive clinical description of the neurologic disease produced by a specific virus and an up-to-date review of the current research in the pathogenesis of the disease, with particular attention given to molecular mechanisms. Most, but not all chapters were written by clinical neurologists who applied basic science strategies and methodologies to the question of how neurotropic viruses produce disease. other chapters were written by virologists known for their longstanding commitment and expertise in the analysis of the pathogenesis of neurotropic virus infections. Thus, this unique monograph should be valuable to all clinicians caring for patients with CNS viral diseases and to "neurovirologists" needing an update of the clinical and molecular pathogenesis of neurotropic virus infections. While this monograph was being prepared, a rapidly expanding literature indicated that the human lenteviruses, human immunodeficiency viruses (HIV) and HTLV-1 were highly neurotropic.

• HIV
• Nervous System
• attention
• central nervous system
• immunodeficiency
• infection
• pathogenesis
• prions
• virology
• virus

• Department of Neurology, University of Colorado Health Sciences Center, Denver, USA

  Donald H. Gilden

• Department of Neurology, Northwestern University Medical School, Chicago, USA

  Howard L. Lipton

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