The Serotonin Receptors

1. Front Matter

   Pages i-xvi

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2. Historical Perspectives

   1. Front Matter

      Pages 1-1

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   2. Historical Perspectives

      • Samuel S. Wang, Stephen J. Peroutka

      Pages 3-20

3. Characterization of Serotonin Receptor Binding Sites

   1. Front Matter

      Pages 21-21

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   2. Biochemistry and Pharmacology of the 5-HT1 Serotonin Binding Sites

      • David L. Nelson

      Pages 23-57

   3. Pharmacology and Biochemistry of the 5-HT2 Receptor

      • Robert A. Lyon, Milt Titeler

      Pages 59-88

   4. Autoradiographic Studies of Serotonin Receptors

      • J. M. Palacios, M. M. Dietl

      Pages 89-138

4. Biochemical Mechanisms of Receptor Action

   1. Front Matter

      Pages 139-139

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   2. 5-HT Receptors Coupled to Adenylate Cyclase

      • Michael De Vivo, Saul Maayani

      Pages 141-179

   3. 5-HT Receptors Coupled to Phosphoinositide Hydrolysis

      • Elaine Sanders-Bush

      Pages 181-198

5. Correlation of Binding Sites with Function

   1. Front Matter

      Pages 199-199

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   2. Autoreceptors Regulating Serotonin Release

      • Derek N. Middlemiss

      Pages 201-224

   3. Electrophysiology of Central Serotonin Receptor Subtypes

      • G. K. Aghajanian, J. S. Sprouse, K. Rasmussen

      Pages 225-252

   4. Behavioral Models of Serotonin Receptor Activation

      • Richard A. Glennon, Irwin Lucki

      Pages 253-293

   5. Serotonin Receptors in Vascular Smooth Muscle

      • Marlene L. Cohen

      Pages 295-316

6. Regulation of Serotonin Receptors

   1. Front Matter

      Pages 317-317

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   2. Regulation of Serotonin Receptors and Responsiveness in the Brain

      • Alan Frazer, Steve J. Offord, Irwin Lucki

      Pages 319-362

7. Future Vistas

   1. Front Matter

      Pages 363-363

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   2. Future Vistas

      • Elaine Sanders-Bush

      Pages 365-366

8. Back Matter

   Pages 367-388

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Serotonin (5-HT) was isolated and chemically characterized nearly four decades ago, and is now generally accepted to function as a neurotransmitter and neuromodulatory agent. Early research focused on the measurement of concentrations, synthesis, and metabolism of 5-HT, and only recently has the focus shifted to characterization of 5-HT receptors. Gaddum and Picarelli first sug­ gested in 1957 that the effect of 5-HT in the guinea pig ileum is mediated by two pharmacologically distinguishable receptors; however, the possibility of dual5-HT receptors was not explored systematically or successfully until the past decade. It is now clear that more, perhaps many more, subclasses of 5-HT receptors exist. The purpose of this book is to provide an up-to-date report on 5-HT receptors. This is a difficult task considering the astonishing speed at which research in this field is expanding. As the first of what we can expect to be a steady stream of monographs focusing on 5-HT receptors, the book confirms that we are in an exciting time in the history of 5-HT. For those of us who have been work­ ing on 5-HT for many years, our dream of equal progress and recognition with the more extensively studied catecholamines is finally being realized. We now have a Serotonin Club that held its first international scientific meeting in 1987, and several more international meetings are in the planning stages.

• Nervous System
• Vivo
• biochemistry
• catecholamines
• cognition
• cortex
• metabolism
• neurotransmitter
• pharmacology
• physiology
• platelets
• protein
• receptor
• signal transduction
• tissue

• Department of Pharmacology and Psychiatry, Vanderbilt University School of Medicine, Nashville, USA

  Elaine Sanders-Bush

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