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Protein Production by Biotechnology

  • Book
  • © 1990

Overview

Editors:
  1. T. J. R. Harris

    1. Glaxo Group Research Limited, Greenford, Middlesex, UK

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Is Bacillus an Alternative Expression System?

    • Jeffery Errington, Andrew Mountain
    Pages 1-14

  3. Expression Systems and Protein Production in Filamentous Fungi

    • Geoffrey Turner
    Pages 15-26

  4. Genetic Engineering Applied to the Development of Vaccines

    • K. Murray, S. Stahl, P. G. Ashton-Rickardt
    Pages 27-48

  5. Towards the Structure of Mosaic Proteins: Use of Protein Expression and NMR Techniques

    • Martin Baron, Alan J. Kingsman, Susan M. Kingsman, Iain D. Campbell
    Pages 49-60

  6. Production of Secreted Proteins in Yeast

    • S. H. Collins
    Pages 61-77

  7. Strategies for Expressing Cloned Genes in Mammalian Cells

    • Mary M. Bendig
    Pages 79-98

  8. Expression of Foreign Proteins by Vaccinia Virus

    • Geoffrey L. Smith
    Pages 99-115

  9. The Expression of Tissue-Type Plasminogen Activator and Related Enzymes

    • M. J. Browne, J. E. Carey, C. G. Chapman, I. Dodd, G. M. P. Lawrence, J. H. Robinson
    Pages 117-129

  10. Expression of Recombinant Factor VIII Molecules in Mammalian Cells

    • Pierre Meulien, Thérèse Faure, Andréa Pavirani
    Pages 131-139

  11. The β-Globin Dominant Control Region

    • Frank Grosveld, Mike Antoniou, Greet Blom van Assendelft, Phil Collis, Niall Dillon, David R. Greaves et al.
    Pages 141-148

  12. The Production of Pharmaceutical Proteins in the Milk of Transgenic Animals

    • Alan E. Smith
    Pages 149-158

  13. The Production of Useful Proteins from Transgenic Plants

    • Michael Bevan, Gabriel Iturriaga
    Pages 159-168

  14. Large Scale Culture of Mammalian Cells for Production of Therapeutic Proteins

    • J. R. Birch
    Pages 169-179

  15. The Role of Molecular Biology in Drug Discovery and Design

    • Dolan B. Pritchett, Peter H. Seeburg
    Pages 181-190

  16. Haemopoietic Growth Factors as Drugs

    • J. H. Scarffe, W. P. Steward, N. G. Testa, T. M. Dexter
    Pages 191-205

  17. Selective Delivery ad Targeting o Therapeutic Proteins

    • E. Tomlinson
    Pages 207-225

  18. Proteins as Therapeutics: Potential and Problems

    • Nowell Stebbing
    Pages 227-238

  19. Back Matter

    Pages 239-243
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Keywords

About this book

There are very few parts of biology that remain free from the influence of Genetic Engineering developed in the early 1970s. Disciplines as wide apart as Brewing, Forensic Science and Population Genetics have all been affected in some way. The major impact, however, has been to create a new science of Biotechnology - a part of which is the production of proteins in a variety of cellular systems. Initially, bacterial systems such as E. coli were used but it soon became apparent that this prokaryotic host was not suitable for the preparation of more complicated proteins. In December 1988, a Symposium sponsored by the Biological Council organised by Dr Chris Hentschel and myself was held at the Middlesex in London to discuss alternative methods of Hospital Medical School protein production and to review some ofthe applications of the proteins so produced. The presentations at this meeting form the substance ofthis book. The theme is apparent from the first part where the expression of proteins and their domains in yeast is described and compared to other fungal and bacterial systems, such as Aspergillus and Bacillus subtilis. The successful use of recombinant yeast to produce hepatitis B surface antigen for vaccine purposes is particularly pertinent.

Editors and Affiliations

  • Glaxo Group Research Limited, Greenford, Middlesex, UK

    T. J. R. Harris

Bibliographic Information

  • Book Title: Protein Production by Biotechnology

  • Editors: T. J. R. Harris

  • DOI: https://doi.org/10.1007/978-1-4613-1565-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Elsevier Science Publishers Ltd 1990

  • Hardcover ISBN: 978-1-85166-401-6Published: 15 February 1990

  • eBook ISBN: 978-1-4613-1565-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 243

  • Topics: Biotechnology, Protein Science

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