Handbook of the Hemopoietic Microenvironment

1. Front Matter

   Pages i-xxii

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2. Hemopoietic Microenvironments

   • John J. Trentin

   Pages 1-86

3. Molecular and Cellular Traffic Across the Marrow Sinuses

   • Marshall A. Lichtman, Charles H. Packman, Louis S. Constine

   Pages 87-140

4. In Vivo Microscopy of Hemopoietic Tissue

   • Robert S. McCuskey

   Pages 141-155

5. Fatty Involution of Marrow and the Role of Adipose Tissue in Hemopoiesis

   • Mehdi Tavassoli

   Pages 157-187

6. Hematopoiesis on Artificial Membranes

   • William H. Knospe

   Pages 189-218

7. Cellular Components of Stroma In Vivo In Comparison With In Vitro Systems

   • Mati Shaklai

   Pages 219-251

8. Stromal Cells in Long-Term Bone Marrow Cultures

   • Peter J. Quesenberry

   Pages 253-285

9. Cultured Stromal Cell Lines from Hemopoietic Tissues

   • Dov Zipori

   Pages 287-333

10. Cellular Interactions in the Regulation of Human Hemopoiesis In Vitro

    • Joao L. Ascensao, Esmail D. Zanjani

    Pages 335-368

11. The Collagenous Hemopoietic Microenvironment

    • Renate E. Gay, C. W. Prince, K. S. Zuckerman, S. Gay

    Pages 369-398

12. The Hemopoietic Extracellular Matrix

    • Kenneth S. Zuckerman, Charles W. Prince, Steffen Gay

    Pages 399-432

13. Bone Marrow Microenvironment

    • N. T. Shahidi, W. B. Ershler

    Pages 433-444

14. Back Matter

    Pages 445-453

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In 1868, Ernst Neumann recognized that blood cells re­ quire continuous replenishment during postnata1life. Before him, the assumption was that cells of the blood, like nerves once formed in the embryo, remain in the body throughout life. Neumann also recognized that this process occurred within the bone marrow, because this tissue provided a fa­ vorable environment for proliferation and differentiation of blood cell precursors. Vera Danchakoff, the Russian embryologist working in the US, in 1916 made an analogy to the soil and the seed. Bone marrow forms the soil, providing a favorable environment for the growth of seed, the hemopoietic stem cell, and other progenitor cells. Imagine in the remote past a heap of similar tree seeds. These seeds develop in our moderate climate into a tall and many branched tree. Suppose the wind bears a part of the seeds away and brings them to a land possessing different environmental conditions, we will say the arc­ tic lands. There the seeds may develop but they may pro­ duce trees no higher than our moss.

• Macrophages
• Vivo
• glycoprotein
• protein
• proteins
• regulation

• Veterans Administration Medical Center, University of Mississippi School of Medicine, Jackson, USA

  Mehdi Tavassoli

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