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Subcellular Basis of Contractile Failure

Proceedings of the Symposium Sponsored by the Council of Cardiac Metabolism, International Society and Federation of Cardiology and International Society for Heart Research, May 11–13, 1989, Ottawa, Canada

  • Conference proceedings
  • © 1990

Overview

Editors:
  1. Borivoj Korecky
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  2. Naranjan S. Dhalla
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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 116)

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Table of contents (20 papers)

  1. Front Matter

    Pages i-ix
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  2. Role of Cations in Heart Function

    1. Front Matter

      Pages 1-1
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    2. Role for Sodium Channels and Intracellular Sodium in Regulation of the Cardiac Force-Frequency Relation and Contractility

      • Craig T. January, Harry A. Fozzard
      Pages 3-17

    3. Regulation of Cardiac Calcium Current during Suppression of Second Messenger Intracellular Enzymatic Pathways

      • T. Asai, H. Terada, Y. M. Shuba, T. F. McDonald, D. Pelzer
      Pages 19-37

    4. Hormonal and Non-Hormonal Regulation of Ca2+ Current and Adenylate Cyclase in Cardiac Cells

      • Rodolphe Fischmeister, Pierre-François Mery, Alvin Shrier, Catherine Pavoine, Véronique Brechler, Françoise Pecker
      Pages 39-54

    5. Calcium Current in Normal and Hypertrophied Isolated Rat Ventricular Myocytes

      • F. Scamps, E. Mayoux, D. Charlemagne, G. Vassort
      Pages 55-67

    6. Regulation of Contractile Activity in Single Adult Cardiomyocytes Isolated from Four Different Species: The Effect of Reduced Sodium Gradient

      • M. Horackova
      Pages 69-83

    7. Involvement of Sodium-Calcium Exchange in Cardiac Pathology

      • G. N. Pierce, T. G. Maddaford
      Pages 85-96

    8. Modifications in Sarcolemmal Regulation of Ca2+ with Aging

      • J. C. Khatter, S. Navaratnam, M. Agbanyo
      Pages 97-111

  3. Cardiac Hypertrophy and Cardiomyopathies

    1. Front Matter

      Pages 113-113
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    2. Alterations of Membrane Proteins in Cardiac Hypertrophy

      • D. Charlemagne
      Pages 115-134

    3. Signal Transduction in Myocardial Hypertrophy and Myosin Expression

      • H. Rupp, R. Jacob, N. S. Dhalla
      Pages 135-154

    4. Molecular and Subcellular Mechanisms of Thyroid Hormone Induced Cardiac Alterations

      • S. C. Black, J. H. McNeill
      Pages 155-171

    5. Membrane Abnormalities and Changes in Cardiac Cations due to Alterations in Thyroid Status

      • Michael J. Daly, Enn K. Seppet, Roland Vetter, Naranjan S. Dhalla
      Pages 173-191

    6. Inhibitory Effects of Captopril on the Onset of Cardiomyopathy in Cardiomyopathic Hamsters

      • M. Kato, N. Takeda, A. Takeda, T. Ohkubo, M. Nagai, M. Nagano
      Pages 193-208

    7. Altered myocardial contractility and energetics in renovascular hypertensive rats

      • N. Takeda, T. Okubo, T. Iwai, A. Tanamura, M. Nagano
      Pages 209-217

    8. Cardiac Phosphatidylethanolamine N-Methylation in Normal and Diabetic Rats Treated with L-Propionylcarnitine

      • C. Ou, S. Majumder, J. Dai, V. Panagia, N. S. Dhalla, R. Ferrari
      Pages 219-234

  4. Ischemic Heart Disease and Cardiac Failure

    1. Front Matter

      Pages 235-235
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    2. Dietary N-3 Polyunsaturated Fatty Acids and Ischemic Heart Disease

      • J. M. J. Lamers, L. M. A. Sassen, J. M. Hartog, C. Guarnieri, P. D. Verdouw
      Pages 237-256

    3. Role of Free Radicals in the Development of Ischemic Heart Disease

      • R. Ferrari, S. Curello, C. Ceconi, E. Pasini, A. Cargnoni, A. Albertini et al.
      Pages 257-271
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Keywords

About this book

This monograph contains 20 selected papers presented at the Symposium on Subcellular Basis of Contractile Failure which was held in Ottawa during May 11-13, 1989 and is designed for the benefit ofthose who were unable to attend this event. It is now increasingly becoming clear that an excessive amount of calcium is intimately involved in the pathogenesis of a wide variety of heart diseases. Accordingly, the investigations concerning the role of calcium chan­ nels and their regulatory mechanisms in heart function as well as of the intra­ cellular calcium overload in cardiac dysfunction are presented here. Since sodium is also considered to influence the cardiac contractile force by chang­ 2 ing the intracellular concentration of calcium through the Na +-Ca+ exchange 2 mechanism in the cell membrane, the role of Na +-Ca+ exchange in heart func­ tion as well as pathology of contractile failure is discussed. In view of the new­ ly discovered implications of the oxygen free radicals in cellular injury, papers concerning the role of these radicals in heart disease are included in this book. For the purpose of clarity, different chapters have been organized under three main headings: (I) Role of cations in heart function, (II) Cardiac hypertrophy and cardiomyopathies, and (III) Ischemic heart disease and cardiac failure.

Bibliographic Information

  • Book Title: Subcellular Basis of Contractile Failure

  • Book Subtitle: Proceedings of the Symposium Sponsored by the Council of Cardiac Metabolism, International Society and Federation of Cardiology and International Society for Heart Research, May 11–13, 1989, Ottawa, Canada

  • Editors: Borivoj Korecky, Naranjan S. Dhalla

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4613-1513-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1990

  • Hardcover ISBN: 978-0-7923-0890-4Published: 30 September 1990

  • Softcover ISBN: 978-1-4612-8813-8Published: 26 September 2011

  • eBook ISBN: 978-1-4613-1513-1Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: X, 332

  • Topics: Cardiology

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