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Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA

  • Book
  • © 1990

Overview

Editors:
  1. Stephen J. Peroutka

    1. Stanford University Medical Center, USA

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Part of the book series: Topics in the Neurosciences (TNSC, volume 9)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xv
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  2. History of MDMA

    • Alexander T. Shulgin
    Pages 1-20

  3. The Therapeutic Use of MDMA

    • George R. Greer, Requa Tolbert
    Pages 21-35

  4. Testing Psychotherapies and Drug Therapies: The Case of Psychedelic Drugs

    • James B. Bakalar, Lester Grinspoon
    Pages 37-52

  5. Recreational Use of MDMA

    • Stephen J. Peroutka
    Pages 53-62

  6. Human Deaths and Toxic Reactions Attributed to MDMA and MDEA

    • Graeme P. Dowling
    Pages 63-75

  7. The Public Health Implications of MDMA Use

    • Jerome Beck
    Pages 77-103

  8. Structure-Activity Relationships of MDMA and Related Compounds: A New Class of Psychoactive Agents?

    • David F. Nichols, Robert Oberlender
    Pages 105-131

  9. Neurochemical Effects of MDMA

    • James W. Gibb, Donna Stone, Michel Johnson, Glen R. Hanson
    Pages 133-150

  10. Neurochemical Effects of Methylenedioxymethamphetamine in the Rat: Acute Versus Long-Term Changes

    • Christopher J. Schmidt, Vicki L. Taylor
    Pages 151-169

  11. MDMA Effects in Brain: Pharmacologic Profile and Evidence of Neurotoxicity from Neurochemical and Autoradiographic Studies

    • George Battaglia, Robert Zaczek, Errol B. De Souza
    Pages 171-199

  12. A Tissue Culture Model of MDMA Toxicity

    • Patrica M. Whitaker-Azmitia, Efrain C. Azmitia
    Pages 201-211

  13. Effect of MDMA-Like Drugs on CNS Neuropeptide Systems

    • Glen R. Hanson, Kalpana M. Merchant, Michel Johnson, Anita A. Letter, Lloyd Bush, James W. Gibb
    Pages 213-224

  14. Neuroendocrinological Effects of MDMA in the Rat

    • J. Frank Nash, Herbert Y. Meltzer
    Pages 225-239

  15. Back Matter

    Pages 241-244
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Keywords

About this book

The variety of viewpoints expressed in this book illustrate the many contro­ versies surrounding MDMA [1]. On the one hand, the proponents ofMDMA use believe this agent offers a unique psychoactive effect that may have important clinical applications, especially in the field of psychotherapy. On the other hand, the scientific data concerning the neurotoxic effects of the drug are unequivocal. The most striking feature of the human information of MDMA is the paucity of data that has been generated on the drug since it was patented in 1914. As pointed out by Beck (Chapter 6) and others, a clear need exists for better epidemiological and clinical data on MDMA. In the absence of such data, arguments both for and against the cotinued use ofMDMA with humans will be difficult to support. Unfortunately, the currently available data must be used to develop rational policies for potential human users of MDMA. At the present time, there are no data indicating that recreational doses of MDMA permanently damage the human brain. Nonetheless, based on a review of the contents of this book as well as on informal discussions with approximately 200 recreational users of MDMA, the following personal observations suggest that MDMA is radically different from other recreational drugs.

Editors and Affiliations

  • Stanford University Medical Center, USA

    Stephen J. Peroutka

Bibliographic Information

  • Book Title: Ecstasy: The Clinical, Pharmacological and Neurotoxicological Effects of the Drug MDMA

  • Editors: Stephen J. Peroutka

  • Series Title: Topics in the Neurosciences

  • DOI: https://doi.org/10.1007/978-1-4613-1485-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1990

  • Hardcover ISBN: 978-0-7923-0305-3Published: 31 December 1989

  • eBook ISBN: 978-1-4613-1485-1Published: 06 December 2012

  • Series ISSN: 0897-3946

  • Edition Number: 1

  • Number of Pages: XVI, 244

  • Topics: Neurology, Veterinary Medicine/Veterinary Science, Neurosciences

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