Vascular Morphogenesis: In Vivo, In Vitro, In Mente

1. Front Matter

   Pages i-xiv

   PDF

2. Vascular Morphogenesis In Vivo

   1. Introduction: Understanding Blood Vessel Assembly in the Embryo

      • Charles D. Little

      Pages 1-2

   2. The Morphogenesis of Primordial Vascular Networks

      • Christopher J. Drake, Charles D. Little

      Pages 3-19

   3. Angiogenesis and Lymphangiogenesis: Analogous Mechanisms and Homologous Growth Factors

      • Jörg Wilting, Haymo Kurz, Su-Ja Oh, Bodo Christ

      Pages 21-34

   4. Ontogeny of the Endothelial Network Analyzed in the Avian Model

      • Françoise Dieterlen-Lievre, Luc Pardanaud

      Pages 35-50

   5. Methodology for the Study of Vascular Morphogenesis In Vivo

      • M. C. DeRuiter, R. E. Poelmann, A. C. Gittenberger-de Groot

      Pages 51-63

   6. Growth Factors in Vascular Morphogenesis: Insights from Gene Knockout Studies in Mice

      • Chitra Suri, George D. Yancopoulos

      Pages 65-71

3. Vascular Morphogenesis In Vitro

   1. Introduction: Regulation of Vascular Morphogenesis

      • E. Helene Sage

      Pages 73-77

   2. Three-Dimensional In Vitro Assay of Endothelial Cell Invasion and Capillary Tube Morphogenesis

      • Roberto Montesano, Michael S. Pepper

      Pages 79-110

   3. The Rat Aorta Model of Angiogenesis and Its Applications

      • Roberto Francesco Nicosia

      Pages 111-129

   4. In Vitro Coculture Models to Study Vessel Formation and Function

      • Karen K. Hirschi, Patricia A. D’Amore

      Pages 131-140

4. Vascular Morphogenesis In Mente

   1. Introduction: Toward the Theoretical Biology of Vascular Morphogenesis

      • Vladimir A. Mironov

      Pages 141-145

   2. Models for the Formation of Netlike Structures

      • Hans Meinhardt

      Pages 147-172

   3. A Mechanical Theory of In Vitro Vascular Network Formation

      • J. D. Murray, D. Manoussaki, S. R. Lubkin, R. Vernon

      Pages 173-188

   4. Blood Vessel Growth: Mathematical Analysis and Computer Simulation, Fractality, and Optimality

      • Haymo Kurz, Konrad Sandau, Jörg Wilting, Bodo Christ

      Pages 189-203

   5. Mathematical Modeling of Tumor-Induced Angiogenesis

      • Mark A. J. Chaplain, Michelle E. Orme

      Pages 205-240

   6. Is the Fractal Nature of Intraorgan Spatial Flow Distributions Based on Vascular Network Growth or on Local Metabolic Needs?

      • James B. Bassingthwaighte, Daniel A. Beard, Zheng Li, Tada Yipintsoi

      Pages 241-259

5. Back Matter

   Pages 261-265

   PDF

The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lineage that progressively and irreversibly assemble into a segmented, primary heart tube that can be remodeled into a four-chambered organ, and (2) how blood vessels are derived and assembled both in the heart and in the body. Our central aim is to establish a four-dimensional, spatiotemporal foundation for the heart and blood vessels that can be genetically dissected for function and mechanism. Since Robert DeHaan's seminal chapter "Morphogenesis of the Vertebrate Heart" pub­ lished in Organogenesis (Holt Reinhart & Winston, NY) in 1965, there have been surprisingly few books devoted to the subject of cardiovascular morphogenesis, despite the enormous growth of interest that occurred nationally and internationally. Most writings on the subject have been schol­ arly compilations of the proceedings of major national or international symposia or multiauthored volumes, often without a specific theme. What is missing are the unifying concepts that can make sense out of a burgeoning database of facts. The Editorial Board of this new series believes the time has come for a book series dedicated to cardiovascular morphogenesis that will serve not only as an important archival and didactic reference source for those who have recently come into the field but also as a guide to the evolution of a field that is clearly coming of age.

• Mesoderm
• Morphogenesis
• Vertebrate
• biology
• blood vessel
• cardiovascular
• cells
• endothelium
• methodology
• ontogeny

• Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, USA

  Charles D. Little, Vladimir Mironov

• Department of Biological Structures, University of Washington School of Medicine, Seattle, USA

  E. Helene Sage

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