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Biochemistry of Signal Transduction in Myocardium

  • Book
  • © 1996

Overview

Editors:
  1. Jos M. J. Lamers

    1. Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine of Health Science, Erasmus University Rotterdam, Rotterdam, The Netherlands

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  2. Pieter D. Verdouw

    1. Department of Cardiology, Cardiovascular Research Institute COEUR, Erasmus University Rotterdam, Rotterdam, The Netherlands

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Part of the book series: Developments in Molecular and Cellular Biochemistry (DMCB, volume 17)

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-1
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  2. Basic Mechanisms

    1. Front Matter

      Pages 3-3
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    2. Phosphoinositide-generated messengers in cardiac signal transduction

      • Han A. A. van Heugten, Yvonne E. G. Eskildsen-Helmond, Henriette W. de Jonge, Karel Bezstarosti, Jos M. J. Lamers
      Pages 5-14

    3. Angiotensin II signalling pathways in cardiac fibroblasts: Conventional versus novel mechanisms in mediating cardiac growth and function

      • David E. Dostal, George W. Booz, Kenneth M. Baker
      Pages 15-21

    4. Signalling by cGMP-dependent protein kinases

      • Arie B. Vaandrager, Hugo R. de Jonge
      Pages 23-30

    5. Regulation of G protein function: Implications for heart disease

      • Johanna T. A. Meij
      Pages 31-38

    6. Regulation and functional significance of phospholipase D in myocardium

      • Yvonne E. G. Eskildsen-Helmond, Han A. A. Van Heugten, Jos M. J. Lamers
      Pages 39-48

    7. Mitogen-activated protein kinase (MAPK) in cardiac tissues

      • Carine Page, Anton F. Doubell
      Pages 49-57

    8. Phosphotransfer reactions as a means of G protein activation

      • Lucia Piacentini, Feraydoon Niroomand
      Pages 59-63

    9. Signalling by protein kinase C isoforms in the heart

      • Michel Pucéat, Guy Vassort
      Pages 65-72

  3. (Patho)Physiological Responses in Myocardium

    1. Front Matter

      Pages 73-73
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    2. Nitric oxide — a retrograde messenger for carbon monoxide signaling in ischemic heart

      • Nilanjana Maulik, Daniel T. Engelman, Masazumi Watanabe, Richard M. Engelman, Dipak K. Das
      Pages 75-86

    3. Expression of cardiac muscle markers in rat myocyte cell lines

      • Gary L. Engelmann, Robert A. Worrell, Richard A. Duff, Patricia S. Grutkoski, Kenneth R. Chien, Richard P. Harvey
      Pages 87-91

    4. Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions

      • Brenda R. Kwak, Habo J. Jongsma
      Pages 93-99

    5. The transphosphatidylation activity of phospholipase D

      • Chang-Hua Yu, Song-Yan Liu, Vincenzo Panagia
      Pages 101-105

    6. Reduction in Gh protein expression is associated with cytodifferentiation of vascular smooth muscle cells

      • Elizabeth Vincan, Craig B. Neylon, Alexander N. Jacobsen, Elizabeth A. Woodcock
      Pages 107-110

    7. Coordinated expression of heme oxygenase-1 and ubiquitin in the porcine heart subjected to ischemia and reperfusion

      • H. S. Sharma, N. Maulik, B. C. G. Gho, D. K. Das, P. D. Verdouw
      Pages 111-116

    8. Sympathetic control of cardiac myosin heavy chain gene expression

      • Mahesh P. Gupta, Madhu Gupta, Evelyn Dizon, Radovan Zak
      Pages 117-124

    9. Regulation of expression of cardiac sarcoplasmic reticulum proteins under pathophysiological conditions

      • Wolfgang H. Dillmann
      Pages 125-128

    10. Expression and regulation of chloride channels in neonatal rat cardiomyocytes

      • Ben C. Tilly, Karel Bezstarosti, Wendy E. M. Boomaars, Christopher R. Marino, Jos M. J. Lamers, Hugo R. de Jonge
      Pages 129-135
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Keywords

About this book

The chapters in this volume are the Proceedings of the Satellite Symposium of the XVIth World Congress of the International Society for Heart Research on `Signal Transduction in Normal and Diseased Myocardium' which was held in Rotterdam at the Faculty of Medicine & Health Sciences of the Erasmus University, June 30 and July 1, 1995.
Diverse and distinct auto-, para-, and endocrine stimuli arriving at the surface of endothelium, smooth muscle cells, cardiomyocytes and fibroblasts within the myocardium, engage cell type-specific receptors, which lead to transmission of signals across the cell plasma membrane and result in the production and activation of second messengers. The most common mechanism by which these second messengers function is via direct or indirect activation of specific protein kinases. The current challenge for scientists is to identify the specific substrates (e.g. metabolic enzymes, Ca2+-regulating proteins, transcription and mitotic factors) for the many protein kinases, to elucidate the biological significance of the cell type-specific expression heterogeneity of signalling proteins (e.g. membrane receptors, isoenzymes of protein kinase C, G-proteins) and to unravel the cross-talk interaction between the signalling systems (e.g. phospholipase C with adenylate cyclase and phospholipase C with phospholipase D). The multiplicity of receptor types, G-proteins, effector proteins, second messengers and protein kinases, their substrate proteins and the `cross-talk' interactions in the myocardium raises fundamental questions about the mechanisms that ensure the precision and timing of the myocardial responses to hormonal and pharmacological stimuli.
This book provides an up-to-date source of information for all scientists and clinicians interested in the mechanisms by which external signals are transmitted to the interior and regulation of a variety of physiological, pathological and pharmacological responses.

Editors and Affiliations

  • Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine of Health Science, Erasmus University Rotterdam, Rotterdam, The Netherlands

    Jos M. J. Lamers

  • Department of Cardiology, Cardiovascular Research Institute COEUR, Erasmus University Rotterdam, Rotterdam, The Netherlands

    Pieter D. Verdouw

Bibliographic Information

  • Book Title: Biochemistry of Signal Transduction in Myocardium

  • Editors: Jos M. J. Lamers, Pieter D. Verdouw

  • Series Title: Developments in Molecular and Cellular Biochemistry

  • DOI: https://doi.org/10.1007/978-1-4613-1275-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1996

  • Hardcover ISBN: 978-0-7923-4067-6Published: 30 June 1996

  • eBook ISBN: 978-1-4613-1275-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VI, 274

  • Topics: Biochemistry, general

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