Natriuretic Peptides in Health and Disease

1. Front Matter

   Pages i-x

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2. The Biochemistry of Atrial Natriuretic Peptides

   • T. Geoffrey Flynn

   Pages 1-19

3. The Guanylyl Cyclase-A Receptor

   • David C. Foster, David L. Garbers, Barbara J. Wedel

   Pages 21-33

4. The Guanylyl Cyclase-B Receptor

   • David G. Lowe

   Pages 35-50

5. Molecular Determinants of Natriuretic Peptide Clearance Receptor Function

   • John A. Lewicki, Andrew A. Protter

   Pages 51-69

6. Cellular and Molecular Aspects of the A-Type Natriuretic Peptide

   • David G. Gardner, Jianming Wu, Branka Kovacic-Milivojevic

   Pages 71-94

7. Cellular and Molecular Biology of B-Type Natriuretic Peptide

   • Christopher C. Glembotski

   Pages 95-106

8. Cellular and Molecular Aspects of C-Type Natriuretic Peptide (CNP)

   • Hiroshi Itoh, Shinichi Suga, Yoshihiro Ogawa, Yasato Komatsu, Naohisa Tamura, Toshio Igaki et al.

   Pages 107-122

9. Physiology of Natriuretic Peptides

   • Eric A. Espiner

   Pages 123-146

10. Renal Actions of Atrial Natriuretic Peptide

    • Markus Meyer, Wolf-Georg Forssmann

    Pages 147-170

11. Physiology of the Natriuretic Peptides

    • Kailash N. Pandey

    Pages 171-191

12. Physiology of the Natriuretic Peptides

    • Zachary Resch, Tonya C. Murphy, Willis K. Samson

    Pages 193-209

13. Natriuretic Peptide Actions in the Brain

    • Alastair V. Ferguson

    Pages 211-221

14. Natriuretic Peptides as Antigrowth Factors

    • Ellis R. Levin

    Pages 223-237

15. Natriuretic Peptides and Salt Sensitivity

    • Daniel Villarreal, Ronald H. Freeman

    Pages 239-258

16. Physiology of the Clearance Receptor

    • George J. Trachte

    Pages 259-274

17. Natriuretic Peptides and Immune Function

    • Angelika M. Vollmar

    Pages 275-288

18. Design and Utilization of Natriuretic Peptide Antagonists

    • Yuzuru Matsuda

    Pages 289-307

19. Natriuretic Peptides in Cardiovascular Disease

    • J. Aaron Grantham, John C. Burnett Jr.

    Pages 309-326

20. Back Matter

    Pages 327-337

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A comprehensive, state-of-the-art review of the biochemistry, molecular and cellular biology, pharmacology, physiology, and pathology of natriuretic peptides. Written by the foremost researchers in the field, the reviews range from describing the actions of these peptides on the kidney, adrenal gland, vasculature, and brain, to their effects on immune regulation, reproduction, and cell growth. Special attention is given to the potential involvement of these hormones in clinical pathology and to their possible therapeutic use. Especially enlightening is the first-time review of molecular understanding of key cellular signaling pathways and of the importance of the vascular smooth muscle-endothelial interface.

• biochemistry
• endothelium
• growth factor
• molecular biology
• physiology
• regulation
• signaling pathways
• smooth muscle

• Department of Physiology, University of North Dakota School of Medicine, Grand Forks, USA

  Willis K. Samson

• Department of Medicine and Pharmacology, University of California at Irvine, USA

  Ellis R. Levin

• Department of Veterans Affairs Medical Center, Long Beach, USA

  Ellis R. Levin

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