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Thrombopoiesis and Thrombopoietins

Molecular, Cellular, Preclinical, and Clinical Biology

  • Book
  • © 1997

Overview

Editors:
  1. David J. Kuter

    1. The MGH Cancer Center, Massachusetts General Hospital, Boston, USA

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  2. Pamela Hunt

    1. Amgen Inc., Thousand Oaks, USA

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  3. William Sheridan

    1. Amgen Inc., Thousand Oaks, USA
      Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, USA

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  4. Dorothea Zucker-Franklin

    1. Department of Medicine, New York University Medical Center, New York, USA

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Megakaryocyte Biology

      • Carl W. Jackson, Julie T. Arnold, Tamara I. Pestina, Paula E. Stenberg
      Pages 3-39

    3. Platelet Structure and Function

      • Dorothea Zucker-Franklin
      Pages 41-62

    4. The Evolution of Mammalian Platelets

      • Jack Levin
      Pages 63-78

    5. Potential Clinical Applications of Thrombopoietic Growth Factors

      • Charles A. Schiffer
      Pages 79-91

  3. The Search for the Physiologic Regulator of Platelet Production

    1. Front Matter

      Pages 93-93
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    2. Historical Perspective and Overview

      • Eric M. Mazur
      Pages 95-108

    3. The Murine Myeloproliferative Leukemia Virus MPLV, v-mpl Oncogene, and c-mpl

      • Françoise Wendling, Sylvie Gisselbrecht
      Pages 109-122

    4. Mpl Expression and Functional Role in Human Megakaryocytopoiesis

      • Françoise Wendling, Najet Debili, William Vainchenker
      Pages 123-134

    5. The Purification and Cloning of Human Thrombopoietin

      • Dan Eaton
      Pages 135-141

    6. The Purification of Thrombopoietin from Thrombocytopenic Plasma

      • David J. Kuter, Hiroshi Miyazaki, Takashi Kato
      Pages 143-164

    7. The Role of Other Hemopoietic Growth Factors and the Marrow Microenvironment in Megakaryocytopoiesis

      • Ronald Hoffman
      Pages 165-178

  4. Molecular Biology

    1. Front Matter

      Pages 179-179
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    2. Structure of Thrombopoietin and the Thrombopoietin Gene

      • Austin L. Gurney, Frederic J. de Sauvage
      Pages 181-188

    3. Transcription Factors in Megakaryocyte Differentiation and Gene Expression

      • Ramesh A. Shivdasani
      Pages 189-202

    4. The Biological Significance of Truncated and Full-Length Forms of Mpl Ligand

      • Donald Foster, Pamela Hunt
      Pages 203-214

  5. Cellular Biology

    1. Front Matter

      Pages 215-215
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    2. In Vitro Effects of Mpl Ligand on Human Hemopoietit Progenitor Cells

      • Najet Debili, Elisabeth Cramer, Françoise Wendling, William Vainchenker
      Pages 217-235

    3. Effect of Cytokines on the Development of Megakaryocytes and Platelets

      • Dorothea Zucker-Franklin
      Pages 237-255
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Keywords

About this book

David Kuter and a host of leading international researchers summarize in one volume all the knowledge of thrombopoietins (TPO) available today. The distinguished experts review the history of the search to discover TPO, describe the molecular and biological characteristics of this new molecule, and present the results of the preclinical animal experiments that will guide clinical use of this new hormone. Along the way they provide the most recent and comprehensive guide to the biology of megakaryocytes and platelets.

Reviews

...a useful reference tool for oncologists, hemtologists, physicians, and medical researchers. -Biological Abstracts/RRM

Editors and Affiliations

  • The MGH Cancer Center, Massachusetts General Hospital, Boston, USA

    David J. Kuter

  • Amgen Inc., Thousand Oaks, USA

    Pamela Hunt, William Sheridan

  • Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, USA

    William Sheridan

  • Department of Medicine, New York University Medical Center, New York, USA

    Dorothea Zucker-Franklin

Bibliographic Information

  • Book Title: Thrombopoiesis and Thrombopoietins

  • Book Subtitle: Molecular, Cellular, Preclinical, and Clinical Biology

  • Editors: David J. Kuter, Pamela Hunt, William Sheridan, Dorothea Zucker-Franklin

  • DOI: https://doi.org/10.1007/978-1-4612-3958-1

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Humana Press Inc. 1997

  • Hardcover ISBN: 978-0-89603-379-5Published: 01 November 1996

  • Softcover ISBN: 978-1-4612-8440-6Published: 17 September 2011

  • eBook ISBN: 978-1-4612-3958-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVIII, 412

  • Topics: Hematology, Human Physiology, Cell Biology

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