Recent Advances and Future Directions in Bone Marrow Transplantation

1. Front Matter

   Pages i-xxiii

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2. Introduction

   1. Introduction

      • Siegmund J. Baum

      Pages 1-2

3. Experimental Bone Marrow Transplantation

   1. Graft-versus-Host Disease and Graft-versus-Leukemia in Experimental Systems

      • James P. OKunewick, Deborah L. Kociban, Mary J. Buffo, Christine K. Young

      Pages 3-11

   2. Syngeneic Graft-versus-Host Disease: Failure of Self: Non-Self Discrimination

      • A. D. Hess, A. C. Fischer, G. B. Vogelsang, W. E. Beschnorner, G. W. Santos

      Pages 12-17

   3. Transfusion-Induced Allosensitization in Marrow Transplant Recipients: Mechanisms and Preventive Measures

      • H. Joachim Deeg, Sherrill J. Slichter, Rainer Storb

      Pages 18-23

4. Experimental Bone Marrow Transplantation

   1. Utilization of Monoclonal Antibodies for Autologous Bone Marrow Transplantation

      • Y. Kodera, Y. Morishima, Y. Moriyama, T. Mori, A. Kanamaru, K. Shinohara et al.

      Pages 24-30

   2. Characterization of Malignant Lymphoma in Dogs and Use as a Model for the Development of Treatment Strategies

      • Frederick R. Appelbaum, Paul A. Brown, Theodore C. Graham, Brenda M. Sandmaier, Friedrich W. Schuening, Rainer Storb

      Pages 31-35

   3. Hematopoietic Cell Transplantation in Murine Globoid Cell Leukodystrophy (The Twitcher Mouse)—A Model of a Human Sphingolipidosis (Krabbe Disease)

      • Andrew M. Yeager, Takao Ichioka, Eitoku Toyoshima, Yasuo Kishimoto, Susan Brennan, Hugo W. Moser et al.

      Pages 36-44

   4. Experimental Basis of Bone Marrow Purging with Chemical and Photodynamic Agents

      • A. Porcellini, A. Manna, M. T. Marchetti-Rossi, F. Centis, N. Talevi, G. Sparaventi et al.

      Pages 45-48

5. Leukemia

   1. Oncogenes in Acute Myelogenous Leukemia

      • Robert Peter Gale, Anna Butturini

      Pages 49-52

   2. Optimal Timing of Marrow Transplantation for Patients with Acute Nonlymphoblastic and Acute Lymphoblastic Leukemia

      • C. Dean Buckner, Reginald A. Clift, Frederick R. Appelbaum, Jean E. Sanders, Kristine Doney, E. Donnall Thomas

      Pages 53-57

   3. Perspectives in Treatment of Adult Leukemia with High Dose Cytoreductive Therapy and Autologous Bone Marrow Treated Ex Vivo

      • Leonard J. Horwitz, Karel A. Dicke, Sundar Jagannath, Gary Spitzer

      Pages 58-73

6. Autologous and Allogenic Marrow Transplants in Leukemia and Lymphoma (Session A)

   1. Allogeneic and Autologous Marrow Transplants in Acute Nonlymphoblastic Leukemia (ANLL)

      • G. W. Santos, A. M. Yeager, R. Saral, W. H. Burns, J. R. Wingard, R. Jones et al.

      Pages 74-81

   2. Allogeneic Transplantation for Acute Lymphoblastic Leukemia

      • A. J. Barrett

      Pages 82-88

   3. Autologous Bone Marrow Transplantation in Acute Lymphoblastic Leukemia—Mafosfamide Italian Study Group

      • V. Rizzoli, L. Mangoni, A. M. Carella, G. Torlontano, M. Aglietta, L. Resegotti et al.

      Pages 89-93

   4. Allogeneic Bone Marrow Transplantation for Chronic Myeloid Leukemia

      • John M. Goldman

      Pages 94-98

7. Autologous and Allogeneic Marrow Transplants in Leukemia and Lymphoma (Session B)

   1. Autologous Marrow Transplantation for Hodgkin’s and Non-Hodgkin’s Lymphoma: Preliminary Results Using New Conditioning Regimens

      • Roger H. Herzig, Gordon L. Phillips, Steven N. Wolff, Joseph W. Fay, C. Frederick LeMaistre, Donna E. Reece et al.

      Pages 99-105

   2. Long-Term Bone Marrow Culture in Autologous Transplantation: An In Vitro Biological System for Purging Leukemic Cells

      • L. H. Coutinho, A. Will, J. Chang, N. G. Testa, T. M. Dexter

      Pages 106-113

   3. Allogeneic Bone Marrow Transplantation for Leukemia—Japanese Experience

      • T. Masaoka

      Pages 114-118

8. Aplastic Anemia

   1. Allogeneic and Syngeneic Marrow Transplantation for Aplastic Anemia: Overview of Seattle

      • Rainer Storb, Kristine Doney, E. Donnall Thomas, Claudio Anasetti, Frederick R. Appelbaum, Patrick Beatty et al.

      Pages 119-124

Siegmund J. Baum It has become a tradition to commence advocated by Leonard Cole) (3). important meetings of this society with At about the same time, Alpen and reminiscence and nostalgia. Bone marrow Baum (4), using a larger mammal, the dog, transplantation, which has a history of only demonstrated that injecting autologous marrow 30 to 40 years, permits this process, since post irradiation would protect lethally some of the early investigators are still with irradiated animals (see Table). Certainly, us. For example, over the past 15 years, we protection was obtained from the cellular have had three symposia in honor of Egon constituents of the bone marrow. Lorenz. As we all know, the team of Lorenz, We undertook to test on dogs the Uphoff and Congdon was involved in the first hypothesis of Gengozian and Makinodum (5) that successful transplantation of syngeneic and increasing the radiation dose will increase allogeneic bone marrow into irradiated immunologic tolerance for allogeneic implants.

• anemia
• bone marrow
• lymphocytes
• lymphoma
• transplantation

• Department of Physiology, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, USA

  Siegmund J. Baum

• Department of Oncology, The John Hopkins Hospital, Baltimore, USA

  George W. Santos

• Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan

  Fumimaro Takaku

Policies and ethics