Experimental Malignant Hyperthermia

1. Front Matter

   Pages i-xiii

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2. Heat Production in Malignant Hyperthermia Susceptible Muscle

   • Charles H. Williams

   Pages 1-6

3. Plasma Catecholamines During Malignant Hyperthermia

   • Charles H. Williams, Susan E. Dozier, Charles W. Gehrke, Klaus O. Gerhardt, Joseph K. Wong

   Pages 7-19

4. Measurement of Biogenic Amines by HPLC-ECD: ECD as a Diagnostic Tool for Malignant Hyperthermia

   • Klaus O. Gerhardt, Charles W. Gehrke, Charles H. Williams, Joseph K. Wong

   Pages 20-29

5. Hemodynamics in Malignant Hyperthermia Susceptible Pigs During Malignant Hyperthermia

   • Charles H. Williams, Susan E. Dozier, Mary Farias

   Pages 30-45

6. Plasma Levels of T4, T3 and rT3 During Malignant Hyperthermia

   • R. R. Anderson, M. A. Akasha, D. A. Nixon, Charles H. Williams

   Pages 46-58

7. Malignant Hyperthermia and the Sarcoplasmic Reticulum Membrane: A Review

   • Mariam A. Marvasti, Charles H. Williams

   Pages 59-77

8. In Vitro Studies of Drugs Affecting Malignant Hyperthermia Muscle

   • Wilfried K. Ilias, Charles H. Williams, Susan E. Dozier, Robert T. Fulfer

   Pages 78-89

9. The Role of the Horse in Studies Relative to Malignant Hyperthermia

   • Charles E. Short, Nora S. Matthews

   Pages 90-99

10. Horses and Ponies as Animal Models for Malignant Hyperthermia

    • Susan V. Hildebrand

    Pages 100-117

11. Malignant Hyperthermia in the Dog: Laboratory Investigations

    • Peter H. Cribb

    Pages 118-120

12. Laboratory Methods for Malignant Hyperthermia Diagnosis

    • Jeffrey E. Fletcher, Henry Rosenberg

    Pages 121-140

13. Malignant Hyperthermia: A Review

    • Michael Denborough

    Pages 141-146

14. Malignant Hyperthermia: Pre- and Post-Dantrolene

    • Mark G. Zukaitis, George P. Hoech Jr., John D. Robinson

    Pages 147-153

15. The Role of the Sympathetic Nervous System in Patients Susceptible to Malignant Hyperthermia

    • J. Hilary Green, F. Richard Ellis, P. Jane Halsall, Iain T. Campbell

    Pages 155-160

16. Back Matter

    Pages 161-166

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Malignant hyperthermia is a genetic disease that causes an extremely high body temperature. The syndrome is triggered by depolarizing muscle relaxants and halogenated gaseous anesthetics, such as halothane. The purpose of the book is to present the latest experimental work and important conclusions to anesthesiologists, surgeons, certified registered nurse anesthesists, operating nurses, cardiovascular and temperature oriented physiologists, basic research scientists interested in heat production in muscle, animal scientists, primarily swine physiologists, and finally, muscle biology scientists. The results are based on sixteen years of experimental investigations with a malignant hyperthermia susceptible pig colony. Consequently, the data and conclusions are more concrete than the clinical data from human patients. The first five chapters present fresh material relating to the detailed biochemical mechanism of heat production during malignant hyperthermia. Subsequent chapters present recent data on malignant hyperthermia in horses and dogs; these additional animal models provide useful material for future studies of malignant hyperthermia pathophysiology. Later sections summarize the laboratory methods currently used for diagnosing malignant hyperthermia in human patients and present valuable data on malignant hyperthermia in the greater Kansas city area over a twenty year period.

• Laboratory
• biology
• cardiovascular
• catecholamines
• diagnosis
• drugs
• dynamics
• hemodynamics
• hyperthermia
• muscle
• pathophysiology
• physiology
• plasma
• production
• research

• Regional Academic Health Center at El Paso Department of Surgery School of Medicine, Texas Tech University Health Sciences Center, El Paso, USA

  Charles H. Williams

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