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Handbook of Psychopharmacology

Volume 20 Psychopharmacology of the Aging Nervous System

  • Book
  • © 1988

Overview

Editors:
  1. Leslie L. Iversen

    1. Neuroscience Research Centre, Merck Sharp &Dohme Research Laboratories, Harlow, Essex, England

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  2. Susan D. Iversen

    1. Neuroscience Research Centre, Merck Sharp &Dohme Research Laboratories, Harlow, Essex, England

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  3. Solomon H. Snyder

    1. Departments of Neuroscience, Pharmacology, and Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, USA

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Neuropathological and Neurochemical Aspects of Alzheimer’s Disease

    • David M. A. Mann
    Pages 1-67

  3. Basal Forebrain Cholinergic Neurons and Alzheimer’s Disease

    • Christine Höhmann, Piero Antuono, Joseph T. Coyle
    Pages 69-106

  4. Neurochemical Studies in Dementia

    • M. Rossor
    Pages 107-130

  5. Chemical Neuroanatomy of Alzheimer’s Disease

    • Clifford B. Saper
    Pages 131-156

  6. Dementia in Parkinson’s Disease

    • Merle Ruberg, Yves Agid
    Pages 157-206

  7. Alzheimer’s Disease: Genetic Theories of Etiology

    • John C. S. Breitner
    Pages 207-235

  8. The Cholinergic Hypothesis of Memory: A Review of Animal Experiments

    • J. J. Hagan, R. G. M. Morris
    Pages 237-323

  9. Behavioral Models of Aging in Nonhuman Primates

    • Reginald L. Dean, Raymond T. Bartus
    Pages 325-392

  10. Cholinergic Drugs and Human Cognitive Performance

    • B. J. Sahakian
    Pages 393-424

  11. Treatment of Dementia with Vasoactive Drugs

    • Richard C. Mohs
    Pages 425-435

  12. New Pharmacological Perspectives on Nootropic Drugs

    • B. P. H. Poschel
    Pages 437-469

  13. Back Matter

    Pages 471-482
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Keywords

About this book

"Psychopharmacology of the Aging Nervous System" was selected as the topic for Volume 20 of the Handbook of PsychopharmacoloffY. Senile dementia is now widely recognized as a medical and social problem likely to reach epidemic proportions by the turn of the century. By that time it is esti­ mated that almost 20% of the population in most developed countries will be over the age of 65 and at a conservative estimate 1 in 10 of them will suffer from a dementing illness. Many symposia have appeared over the last few years describing the neuropathological and neurochemical deficiencies in Alzheimer's and other forms of dementia, the neuropsychological features of the disease, and attempts to treat it. In this volume, we have selected topics and authors who are beginning to question some of the earlier assumptions and to ask different questions about dementia. In the first four chapters the neuropathology and neu­ rochemistry of dementia are reevaluated. It is important to understand the relationship between the formation of amyloid plaques and neurofibrillary tangles, the progressive degeneration in cortex, and the neurochemical deafferentation of cortex. In particular, the possibility is considered that the most severe pathology is seen in a well-defined limbo/cortical circuitry known to be involved in mnemonic processing. The growing interest in the genetic determinants of familial Alz­ heimer's is reviewed. It is also recognized that detailed comparisons of the neural and psychological characteristics of the various degenerative dis­ eases that impair cognitive processing may be valuable.

Editors and Affiliations

  • Neuroscience Research Centre, Merck Sharp &Dohme Research Laboratories, Harlow, Essex, England

    Leslie L. Iversen, Susan D. Iversen

  • Departments of Neuroscience, Pharmacology, and Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, USA

    Solomon H. Snyder

Bibliographic Information

  • Book Title: Handbook of Psychopharmacology

  • Book Subtitle: Volume 20 Psychopharmacology of the Aging Nervous System

  • Editors: Leslie L. Iversen, Susan D. Iversen, Solomon H. Snyder

  • DOI: https://doi.org/10.1007/978-1-4613-0933-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1988

  • Softcover ISBN: 978-1-4612-8252-5Published: 26 September 2011

  • eBook ISBN: 978-1-4613-0933-8Published: 11 November 2013

  • Edition Number: 1

  • Number of Pages: XVIII, 500

  • Number of Illustrations: 21 b/w illustrations

  • Topics: Pharmacology/Toxicology, Neurosciences

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