Microvascular Mechanics

1. Front Matter

   Pages i-xiii

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2. Systemic Microvascular Mechanics

   1. Front Matter

      Pages 1-1

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   2. Future Trends in Microcirculation Research

      • Benjamin W. Zweifach

      Pages 3-12

   3. Transit Time Distributions of Blood Flow in the Microcirculation

      • Herbert H. Lipowsky, Colin B. McKay, Junji Seki

      Pages 13-27

   4. Particles as Flow Tracers

      • Stephen H. Nellis, Kathleen L. Carroll

      Pages 28-38

   5. Theoretical and Experimental Analysis of Hematocrit Distribution in Microcirculatory Networks

      • Timothy W. Secomb, Axel R. Pries, Peter Gaehtgens, Joseph F. Gross

      Pages 39-49

   6. Dispersion of Blood Cell Flow in Microvascular Networks

      • Axel R. Pries, Peter Gaehtgens

      Pages 50-64

   7. Bioengineering Analysis of Blood Flow in Resting Skeletal Muscle

      • Geert W. Schmid-Schönbein, Thomas C. Skalak, Donald W. Sutton

      Pages 65-99

3. Pulmonary Microvascular Mechanics

   1. Front Matter

      Pages 101-101

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   2. Pulmonary Capillary Blood Pressure

      • Scott A. Barman, Doris Cope, Ronald C. Allison, Aubrey E. Taylor

      Pages 103-117

   3. Sites of Vasoactivity in the Pulmonary Circulation Evaluated Using Rapid Occlusion Methods

      • John H. Linehan, Christopher A. Dawson, Thomas A. Bronikowski, David A. Rickaby

      Pages 118-133

   4. Sites of Vasoactivity in the Pulmonary Circulation Evaluated Using a Low-Viscosity Bolus Method

      • Christopher A. Dawson, Thomas A. Bronikowski, John H. Linehan, David A. Rickaby

      Pages 134-146

   5. Volumetric Changes of Pulmonary Capillaries as Assessed by a Density Method

      • Jen-Shih Lee, Lian-Pin Lee

      Pages 147-162

   6. Direct Measurement of Pulmonary Capillary Transit Time and Recruitment

      • Wiltz W. Wanger Jr.

      Pages 163-174

   7. Elasticity of Microvessels in Postmortem Human Lungs

      • Rong-Tsu Yen

      Pages 175-190

   8. Connection of Micro- and Macromechanics of the Lung

      • Yuan-Cheng Fung

      Pages 191-217

4. Back Matter

   Pages 219-222

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. . . we do not know a truth without knowing its cause. Aristotle Perhaps the greatest hope that may be entertained for a scientific work, whether experimental or theoretical, is that it leads to new thoughts and new avenues of investigation on the part of its readers. In microvascular mechanics, the interplay of rheology, anatomy, and cellular and organ function has only just begun to be addressed. To understand the operational behavior of microcirculation, there is a need to integrate studies at the cellular or molecu­ lar level with a quantitative, biomechanical description of the circulatory system. The symposium entitled "Frontiers in Cardiopulmonary Mechanics" held in June 1988 at the University of Virginia was intended to provide a fundamental approach to the description of the circulation from the per­ spective of microvascular mechanics and to examine new methodology that may advance this effort. This book arose out ofthe work presented at the symposium. Aristotle expressed well the need to pursue the causes of a phenomenon in order to achieve a truthful understanding of its nature. In this spirit has each of the quantitative sciences progressed, and in this spirit we hope that this book will provide some understanding of the microvascular events and bio­ mechanical mechanisms underlying the behavior of circulation in general, and of pulmonary and skeletal muscle microcirculation in particular. The integrated treatment of pulmonary and systemic microcirculation provided here is intended to encourage the cross-fertilization of these two research fields.

• Bolus
• bioengineering
• blood cell
• pulmonary mechanics
• skeletal muscle

• Department of Biomedical Engineering Health Sciences Center, University of Virginia, Charlottesville, USA

  Jen-Shih Lee, Thomas C. Skalak

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