Gene Regulation by Steroid Hormones IV

1. Front Matter

   Pages i-xi

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2. Towards a Molecular Understanding of Steroid Binding to Glucocorticoid Receptors

   • S. Stoney Simons Jr.

   Pages 1-22

3. Regulation of Glucocorticoid Receptor Protein and Gene Expression by Glucocorticoids

   • Yan Min Wang, Kerry Burnstein, Corinne Silva, Deborah Bellingham, Douglas Tully, Jorge Simental et al.

   Pages 23-40

4. Modulation of Glucocorticoid-Induced Responses by Cyclic AMP in Lymphoid Cell Lines

   • Donald J. Gruol, Maureen T. Harrigan, Suzanne Bourgeois

   Pages 41-61

5. Differential Regulation of Tyrosine Amino-Transferase by Glucocorticoids: Transcriptional and Post-Transcriptional Control

   • E. Brad Thompson, P. Gadson, G. Wasner, S. S. Simons Jr.

   Pages 63-77

6. Steroid Response Elements. Definition of a Minimal Promoter and Interaction with Other Activating Sequences

   • W. Schmid, U. Strahle, R. Mestril, G. Klock, W. Ankenbauer, G. Schutz

   Pages 78-89

7. GHF-1, a Tissue-Specific Transcription Factor, is a Homeobox Protein

   • José-Luis Castrillo, Lars E. Theill, Mordechai Bodner, Michael Karin

   Pages 90-109

8. Regulation of EGF Receptors and Nuclear Protooncogenes by Estrogen

   • D. S. Loose-Mitchell, C. Chiappetta, R. M. Gardner, J. L. Kirkland, T.-H. Lin, R. B. Lingham et al.

   Pages 110-132

9. Regulation of the Rat Insulin II Gene: cis- and trans-acting Factors

   • Young-Ping Hwung, David T. Crowe, Lee-Ho Wang, Sophia Y. Tsai, Ming-Jer Tsai

   Pages 133-143

10. Thyroid Hormone Regulation of Rat Liver S14 Gene Expression

    • Donald B. Jump

    Pages 144-162

11. Hormonal and Developmental Regulation of Xenopus Egg Protein Genes

    • J. R. Tata, H. Lerivray, J. Marsh, S. C. Martin

    Pages 163-181

12. Inhibition of the Intracellular Transformation of Rat Ventral Prostate Androgen Receptor by 3′-Deoxyadenosine

    • Richard A. Hiipakka, Shutsung Liao

    Pages 182-198

13. Androgen Action in Rat Liver: Changes in Androgen Sensitivity During Maturation and Aging

    • B. Chatterjee, W. F. Demyan, W. Gallwitz, J. M. Kim, M. A. Mancini, D. H. Oh et al.

    Pages 199-212

14. Inhibition of Cell Proliferation by a Nuclear Type II Ligand: Methyl P-Hydroxyphenylactate

    • Barry M. Markaverich, Brian S. Middleditch, James Clark

    Pages 213-219

15. Promoter Specific Activating Domains of the Chicken Progesterone Receptor

    • Orla M. Conneely, Denise Kettelberger, Ming-Jer Tsai, Bert W. O’Malley

    Pages 220-233

16. Back Matter

    Pages 235-239

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The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds. In this volume, which sum­ marizes our fourth meeting, these advances are very evident. What seemed like science fiction ten years ago has become commonplace science. Who would have imagined that we could synthesize a nucleotide sequence that binds a specific steroid receptor and acts as a controlling element for gene expression? No one; but as is evident from the results reported in several chapters, this technique is yielding a wealth of information. Using these and other techniques it has become apparent that gene transcription is controlled by interactions between transacting factors and DNA recognition sequences (response elements). These transacting factors appear to be members of a large gene family that includes steroid hormone receptors, transcription factors, protooncogenes and homeobox proteins. Thus a great deal has been learned, but as usual, questions remain. Many of these questions are posed by the findings and observations found in several chapters in this volume. Non­ hormone binding forms of steroid receptors and their relevance to receptor down regulation, recycling and biological response remain a mystery. The quantitative relationship between receptor binding and biological response still presents agonizing problems. These and many other intriguing questions are discussed in this volume and set the stage for what should be a most rewarding time in endocrinology. Winter 1989 ARUN K.

• DNA
• EGF receptor
• Insulin
• Nucleotide
• Regulation
• gene expression
• hormone receptors
• proteins
• tissue
• transcription

• Division of Molecular Genetics, Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, USA

  Arun K. Roy

• Department of Cell Biology, Baylor College of Medicine, Houston, USA

  James H. Clark

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