Myelination and Demyelination

1. Front Matter

   Pages i-viii

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2. Neurobiology of Glial Cells

   1. Human Oligodendrocytes in Culture: Biology and Immunology

      • Seung U. Kim

      Pages 1-15

   2. Neurological Lineages and Neurological Diseases

      • Kenji Mokuno, Pierluigi Baron, Judy Grinspan, Gen Sobue, Barbara Kreider, David Pleasure

      Pages 17-28

   3. Human Glial Cells and Growth Factors

      • Voon Wee Yong, Myong W. Kim, Seung U. Kim

      Pages 29-48

3. Molecular Biology of Oligodendrocytes

   1. Molecular Genetics of Myelin Basic Protein in Mouse and Humans

      • John Kamholz

      Pages 49-59

   2. The Primary Structure of Myelin Associated Glycoprotein Suggests a Role in Myelination

      • Monique Arquint, Michael B. Tropak, Paul W. Johnson, Robert J. Dunn, John C. Roder

      Pages 61-84

   3. Molecular Genetics of Myelin Proteolipid Proteins and Their Expression in Normal and Jimpy Mice

      • K. Mikoshiba, C. Shiota, K. Ikenaka

      Pages 85-96

4. Electrophysiology of Glial Cells

   1. The Ionic Channels of Glial Cells

      • C. Krieger, S. U. Kim

      Pages 97-111

   2. Physiological Function of Inward Potassium Currents in Bovine Oligodendrocytes in Culture

      • James G. McLarnon, Seung U. Kim

      Pages 113-120

5. Virus Infection and Demyelination

   1. Molecular Determinants in Autoimmunity

      • Robert S. Fujinami

      Pages 121-128

   2. Viruses And Demyelination

      • Richard A. Shubin, Leslie P. Weiner

      Pages 129-143

   3. Retroviral Disease of The Nervous System

      • B. Weinshenker, G. P. A. Rice

      Pages 145-152

   4. Herpes Simplex Virus Type 1 (HSV1): A Murine Model of Virus Induced Central Nervous System Demyelination

      • L. Kastrukoff, A. Lau, D. Osborne, S. U. Kim

      Pages 153-171

6. Neuroimmunology of multiple Sclerosis

   1. Experimental Allergic Encephalomyelitis as a Model of Multiple Sclerosis

      • Ellsworth C. Alvord Jr.

      Pages 173-185

   2. Immune regulation in multiple sclerosis

      • P. Jack Antel, Rolf Loertscher

      Pages 187-204

   3. In Vivo and in Vitro Abnormal IgG Regulation in Multiple Sclerosis

      • Joel Oger

      Pages 205-218

   4. Studies of Myelin Breakdown in Vitro

      • D. Johnson, R. Toms, H. Weiner

      Pages 219-236

   5. Autoantibodies to Myelin Basic Protein In Multiple Sclerosis

      • K. G. Warren, I. Catz

      Pages 237-258

7. Clinical Aspects of multiple Sclerosis

   1. Magnetic Resonance Imaging in Demyelination

      • D. W. Paty

      Pages 259-272

8. Back Matter

   Pages 273-275

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In June 1987, neurobiologists, immunologists, molecular biologists, virologists and neurologists from several countries met in Vancouver to discuss recent advances of relevance to multiple sclerosis. The symposium was a part of the 22nd Canadian Congress of Neurological Sciences meeting and was sponsored by funds from the Multiple Sclerosis Society of Canada and the Medical Research Council of Canada. The presentations covered five major topics: basic neurobiology, molecular biology, the role of viruses in demyelination, immune function and dysfunction in multiple sclerosis, and clinical magnetic resonance imaging studies. It was heartening to note that scientists from several different disciplines were working towards a common end-point: the understanding and treatment of multiple sclerosis. In this book, speakers at the symposium have each presented a chapter of their findings and discussions. In addition, some non-participants at the symposium have been invited to submit chapters in order to give this volume a more complete scope. It is hoped that the reader will find this book a useful reference for several subjects of interest to multiple sclerosis. In closing, I would like to thank the following for their help and support: the Multiple Sclerosis Society of Canada and the Medical Research Council of Canada for their financial support; the contributors of this book for their manuscripts; Dr. A. Eisen, Mrs. K. Eisen, Mrs. P. Bodnarchuk and Mrs. M. Kim for their efforts in planning and organizing the symposium; and Ms. Catherine Schikowski for her secretarial assistance. Seung U. Kim, M.D. Ph.D.

• biology
• magnetic resonance imaging (MRI)
• multiple sclerosis
• nervous system
• neurobiology
• physiology

• University Hospital, University of British Columbia, Vancouver, Canada

  Seung U. Kim

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