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Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis

  • Book
  • © 1988

Overview

Editors:
  1. Claude L. Malmendier

    1. Research Foundation on Atherosclerosis, Brussels, Belgium
      The Free University of Brussels, Brussels, Belgium

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    You can also search for this editor in PubMed   Google Scholar

  2. Petar Alaupovic

    1. Lipoprotein and Atherosclerosis Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 243)

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Table of contents (42 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Eicosanoids

    1. Prostacyclin, EDRF and Atherosclerosis

      • Salvador Moncada
      Pages 1-11

    2. Control of Prostacyclin Production by Vascular Cells : Role of Adenine Nucleotides and Serotonin

      • J. M. Boeynaems, D. Demolle, S. Pirotton, E. Raspe, M. Lecomte, A. Hepburn et al.
      Pages 13-20

    3. Prostacyclin and Atherosclerosis -Experimental and Clinical Approaches

      • R. J. Gryglewski, E. Kostka-Trabka, A. Dembinska-Kiec, R. Korbut
      Pages 21-29

    4. Platelet-Neutrophil Interactions in the Eicosanoid Pathway

      • Aaron J. Marcus, Lenore B. Safier, Harris L. Ullman, Naziba Islam, M. Johan Broekman, J. R. Falck et al.
      Pages 31-36

    5. Arterial Cell Interactions: Mechanistic Studies Related to Eicosanoid and Growth Factor-Induced Alterations in Cholesterol Metabolism

      • David P. Hajjar, Aaron J. Marcus, Kenneth B. Pomerantz, Katherine A. Hajjar
      Pages 37-45

    6. Effects of Plasma Lipoproteins on Eicosanoid Metabolism by Cultured Vascular Smooth Muscle Cells

      • Jacky Larrue
      Pages 47-54

    7. Eicosanoid Synthesis in Platelet-Derived Growth Factor-Stimulated Fibroblasts

      • Andreas J. R. Habenicht, Peter Salbach, Matthias Goerig
      Pages 55-59

  3. Genetics of Apolipoproteins

    1. Genetic HDL Deficiency States

      • J. M. Ordovas, D. C. King, E. J. Schaefer
      Pages 61-65

    2. Apolipoprotein A-I: Deficiency in Tangier Disease

      • Marie-France Dumon, Monique Clerc, Michel Clerc
      Pages 67-73

    3. Apolipoprotein C-II Deficiencies: In Vivo Models for Assessing the Significance of Defective Lipolysis on Lipoprotein Metabolism

      • W. Carl Breckenridge
      Pages 75-79

    4. Genetic Variation in the Apolipoproteins C-II and C-III

      • R. E. Ferrell, M. I. Kamboh, B. S. Sepehrnia, L. L. Adams-Campbell, K. M. Weiss
      Pages 81-85

    5. The Effect of Apolipoprotein E Allele Substitutions on Plasma Lipid and Apolipoprotein Levels

      • Louis M. Havekes, Peter de Knijff, Marijke Smit, Rune R. Frants
      Pages 87-93

    6. Molecular Genetics of Coronary Heart Disease

      • David J. Galton
      Pages 95-105

  4. Structure of Apolipoproteins and Lipoproteins

    1. Molecular Biology of Human Apolipoprotein B and Related Diseases

      • Vassilis I. Zannis, M. Mahmood Hussain, Margarita Hadzopoulou-Cladaras, Anastasia Kouvatsi, Dimitris Kardassis, Christos Cladaras
      Pages 107-121

    2. Secondary and Tertiary Structure of Apolipoproteins

      • Mary T. Walsh, James A. Hamilton, David Atkinson, Donald M. Small
      Pages 123-132

    3. Prediction of the Tertiary Structure of Apolipoprotein A-II by Computer Modeling

      • J-L De Coen, C. Delcroix, J-F. Lontie, C. L. Malmendier
      Pages 133-137

    4. Relationship Between Structure and Metabolism of HDL Apolipoproteins; Study with Synthetic Peptides

      • Gabriel Ponsin
      Pages 139-147

    5. Heterogeneity in the Conformation of Apo A-I on the Surface of HDL Particles

      • M. Ayrault-Jarrier, E. Bekaert, E. Petit, D. Pastier, J. Polonovski, B. Pau et al.
      Pages 149-155

    6. Structural Properties of the Heparin-Binding Domains of Human Apolipoprotein E

      • Alan D. Cardin, Richard L. Jackson
      Pages 157-163
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Keywords

About this book

Plasma lipoproteins constitute a unique macromolecular system of lipid-protein complexes responsible for the transport of lipids from their sites of origin to their sites of utilization either as metabolic fuel or as structural components of cell membranes. Although studies on the role of lipoproteins in the mechanism of lipid transport are meritorious in their own right, the ever-increasing interest in chemical and functional properties of this remarkable class of conjugated proteins stems from the impressive evidence of their direct involvement in the genesis and develop­ ment of atherosclerotic lesions. The initial emphasis on neutral lipids and phospholipids as the most characteristic constituents of operationally­ defined lipoprotein classes has shifted in recent years to their protein moieties or apolipoproteins. The discovery of a number of apolipoproteins and characterization of familial hypolipoproteinemias as apolipoprotein deficiency disorders indicated that apolipoproteins play an essential role in maintaining the structural stability and integrity of lipoprotein particles. In addition to their role in the formation of lipoproteins, apolipoproteins were shown to perform a variety of functions in metabolic conversion of lipoproteins and their interactions with cellular surfaces. Results from several laboratories have demonstrated that the chemical and metabolic heterogeneity of operationally-defined lipoprotein classes is due to the presence of several discrete lipoprotein particles with similar physical properties but different and characteristic apolipoprotein composition. Thus, the apolipoproteins have emerged not only as essential structural and functional constituents of lipoproteins but also as unique chemical markers for identifying and classifyinglipoprotein particles.

Editors and Affiliations

  • Research Foundation on Atherosclerosis, Brussels, Belgium

    Claude L. Malmendier

  • The Free University of Brussels, Brussels, Belgium

    Claude L. Malmendier

  • Lipoprotein and Atherosclerosis Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA

    Petar Alaupovic

Bibliographic Information

  • Book Title: Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis

  • Editors: Claude L. Malmendier, Petar Alaupovic

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4613-0733-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1988

  • Softcover ISBN: 978-1-4612-8055-2Published: 18 October 2011

  • eBook ISBN: 978-1-4613-0733-4Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 362

  • Topics: Protein Science, Angiology

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