NMR: Principles and Applications to Biomedical Research

1. Front Matter

   Pages i-xvi

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2. Principles of Pulse NMR Spectroscopy

   • T. C. Farrar

   Pages 1-36

3. Relaxation Theory with Applications to Biological Studies

   • D. E. Woessner

   Pages 37-67

4. Two-Dimensional Fourier Transform NMR: Homonuclear and Heteronuclear Couplings-Multiple Quantum Filtering

   • A. A. Bothner-By

   Pages 68-78

5. High-Resolution NMR of Solids

   • J. S. Frye

   Pages 79-98

6. Artificial Intelligence Techniques and NMR Spectroscopy: Application to the Structure of Proteins in Solution

   • B. S. Duncan, J. F. Brinkley, R. B. Altman, B. G. Buchanan, O. Jardetzky

   Pages 99-123

7. Application of Solid State NMR to the Lipids of Model and Biological Membranes

   • I. C. P. Smith

   Pages 124-156

8. Application of 31P NMR to Eye Research

   • T. Glonek, J. V. Greiner, J. H. Lass

   Pages 157-203

9. 31P NMR of Brain Aging and Alzheimer’s Disease

   • J. W. Pettegrew, G. Withers, K. Panchalingam

   Pages 204-254

10. NMR Spectroscopy of Tumors

    • J. D. Glickson, J. P. Wehrle, S. S. Rajan, S. J. Li, R. G. Steen

    Pages 255-309

11. Solid State 31P and 27Al NMR Studies of Model Membranes and Mammalian Brain: Possible Implications for Alzheimer’s Disease

    • J. W. Pettegrew, K. Panchalingam

    Pages 310-354

12. 23Na and 7Li NMR Studies of Mammalian Cells: Assessment of Cation Transport and Cytoskeletal Structure with Application to Manic Depressive Disease

    • J. W. Pettegrew, D. E. Woessner

    Pages 355-400

13. Theory and Technique of Surface Coils in In Vivo Spectroscopy

    • M. R. Bendall

    Pages 401-428

14. 31P in vivo Spectroscopy of Adult Human Brain

    • K. M. A. Welch

    Pages 429-467

15. 1H-NMR Spectroscopy of Brain

    • G. A. Rosenberg, E. Kyner, C. Gasparovic, R. H. Griffey, N. A. Matwiyoff

    Pages 468-484

16. Nuclear Magnetic Resonance and Cell pH with a Focus on Brain pH

    • S. Adler

    Pages 485-505

17. Introduction to NMR Imaging

    • I. J. Lowe

    Pages 506-521

18. NMR Imaging: Techniques and Developments

    • J. C. Gore

    Pages 522-535

19. Contrast Media for MRI: Present and Future Applications

    • G. L. Wolf

    Pages 536-549

20. NMR Imaging of the Human Brain-Insights into Neurological Diseases

    • R. E. Latchaw

    Pages 550-585

Nuclear magnetic resonance (NMR) is having an enormous liTIpact on biomedical research both at the basic science and clinical levels. In order to appreciate the elegance and power of this technology a historical perspective is in order. In 1924 Pauli suggested that hydrogen nuclei might possess a magnetic IIlOlllent. This was in fact confinned by Rabbi in 1939 who demonstrated that a beam of hydrogen molecules in the presence of a magnetic field could be mutated by radio frequency fields resonating at the Iarmor frequency. 'Ihe first successful NMR experiments in condensed matter were independently conducted in late 1945 by Purcell, Torrey and PoUnd and by Bloch, Hansen and Packard. 'Ihe Purcell group detected proton NMR in solid paraffin and the Bloch group detected proton in liquid water. Bloch and Purcell received the Nobel Prize in physics in 1952 for these observations . Until about 1952, studies of liquids and solids with broad resonance lines dominated the field of NMR. However, the reports of 3 1 P NMR chemical shifts in several corrpounds in 1949 by Khight, of 14 N resonances in several ions by Proctor and Yu in 1950, and of 1 9 F resonances in several corrpounds in 1950 by Dickinson led to the development of high resolution NMR in Itquids. since the molecular motions in liquids result in very narrow lines compared to those in solids, :much smaller chemical shifts could be detected.

• Optische Kohärenztomografie
• imaging
• liquid water
• magnetic resonance
• protein
• spectroscopy
• transport

• The Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA

  Jay W. Pettegrew

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