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Biology of Cellular Transducing Signals

  • Book
  • © 1990

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Editors:
  1. Jack Y. Vanderhoek

    1. The George Washington University Medical Center, USA

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Table of contents (41 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Receptors

    1. Real-Time Analysis of Macromolecular Assembly During Cell Activation

      • L. A. Sklar, W. N. Swann, S. P. Fay, Z. G. Oades
      Pages 1-10

    2. Identification of Residues Essential for the Active Conformation of the ß-Adrenergic Receptor by Site-Directed Mutagenesis

      • Mari R. Candelore, Sandra L. Gould, Wendy S. Hill, Anne H. Cheung, Elaine Rands, Barbara A. Zemcik et al.
      Pages 11-19

    3. Mechanisms for Diversification of Responses of Human Polymorphonuclear Leukocytes to Leukotrienes

      • Catherine H. Koo, Jeffrey W. Sherman, Laurent Baud, Winzhen Jin, Kai Mai, Edward J. Goetzl
      Pages 21-27

    4. The Role of Covalent and Non-Covalent Mechanisms in Insulin Receptor Action

      • Paul L. Rothenberg, C. Ronald Kahn
      Pages 29-38

    5. EGF Triggers a Similar Signalling Cascade in Different Cell Types Overexpressing the EGF Receptor

      • Marco Ruggiero, Timothy P. Fleming, Toshimitsu Matsui, Eddi di Marco, Christopher Molloy, Pier Paolo di Fiore et al.
      Pages 39-47

    6. Second Messenger Receptors in the Phosphoinositide Cycle

      • Solomon H. Snyder, Christopher D. Ferris, Anne B. Theibert
      Pages 49-59

    7. Mechanisms of Receptor Regulation for the Phosphoinositide Signalling System

      • Frank S. Menniti, Haruo Takemura, Hiroshi Sugiya, James W. Putney Jr.
      Pages 61-72

    8. Computer Simulation of Prostaglandin-Regulated Cyclic AMP Metabolism in Platelets: Activation and Desensitization of Adenylate Cyclase Appear to be Mediated Through Separate Prostaglandin Receptors Coupled to GS and Gi

      • Barrie Ashby
      Pages 73-82

  3. G Proteins

    1. The Family of G Proteins

      • Eva J. Neer, Yung-Kang Chow, Suzanne Garen-Fazio, Thomas Michel, Carl J. Schmidt, Seth Silbert
      Pages 83-91

    2. Roles of G Protein Subunits in Coupling of Receptors to Ionic Channels and Other Effector Systems

      • Lutz Birnbaumer, Atsuko Yatani, Rafael Mattera, Juan Codina, Arthur M. Brown
      Pages 93-106

    3. Receptor-Mediated Alterations of Calcium Channel Function in the Regulation of Neurosecretion

      • Kathleen Dunlap, George G. Holz
      Pages 107-114

    4. Antibodies as Probes of G-Protein Structure and Function

      • Allen M. Spiegel, William F. Simonds, Paul K. Goldsmith, Cecilia G. Unson
      Pages 115-123

    5. Transducin: A Model of Biological Coupling Enzymes

      • Yee-Kin Ho
      Pages 125-132

    6. Co-Localization by Immunofluorescence of the α Subunit(S) of Gi with Cytoplasmic Structures

      • Jean M. Lewis, Marilyn J. Woolkalis, George L. Gerton, David R. Manning
      Pages 133-140

    7. ‘Cross-Talk’ and the Regulation of Repatocyte Adenylate Cyclase Activity: Desensitization, G1 and Cyclic AMP Phosphodiesterase Regulation

      • Miles D. Houslay
      Pages 141-152

    8. Activation of Human Neutrophils by Granylocyte-Macrophage Colony-Stimulating Factor: Role of Guanine-Nucleotide Binding Proteins

      • R. I. Sha’afi, J. Gomez-Cambronero, M. Yamazaki, M. Durstin, T. F. P. Molski, C.-K. Huang
      Pages 153-162

    9. Cytoskeletal Participation in the Signal Transduction Process: Tubulin G Protein Interactions in the Regulation of Adenylate Cyclase

      • Kun Yan, Mark M. Rasenick
      Pages 163-172

    10. Initiation and Modulation of Signal Output from the T cell Antigen Receptor

      • Robert T. Abraham, James A. Augustine, Janis W. Schlager, Thomas J. Barna, Paul J. Leibson
      Pages 173-183

    11. Selective Phosphorylation of a G Protein within Permeabilized and Intact Platelets Caused by Activators of Protein Kinase C

      • Kenneth E. Carlson, Lawrence F. Brass, David R. Manning
      Pages 185-192
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Keywords

About this book

Intercellular communication in multicellular organisms enables cells to respond to environmental changes. Intercellular signal transduction transmitters include hormones, peptide growth factors, neurotransmitters as well as some lipid-soluble mediators. Once signalling molecules are bound to their cell surface receptors, one or more intracellular signals are generated which alter the Qehavior of the target cell. The IXth International Washington Spring Symposium at the George Washington University in Washington, D.C. was organized to assess the current status of the field of signal transduction processes and regulatory mechanisms. The symposium was held on May 8-'.2, 1989 and was attended by more than 1000 scientists from 30 countries. Most of the papers presented at the plenary sessions have been collected in this volume. The first section of this book details the action and regulation of receptors such as ,B-pdr.'nergic receptors and receptors for EGF, insulin, leukotrienes, phosphoinositides and prostaglandins. Section two focuses on the family of guanine nucleotide regulatory proteins (G proteins). These G proteins are known to mediate the coupling of receptor-mediated signals to several intracellular effector systems. Papers are presented describing the intracellular localization of G proteins, the utilization of G protein antibodies, the interaction of G proteins with tubulin and the involvement of G proteins in the regulation of ion channels, adenylate cy~lase and in the activation of neutrophils and T cells. In the third section, several papers describe the second messenger role of phosphoinositides as well as the regulation of phosphoinositide production.

Editors and Affiliations

  • The George Washington University Medical Center, USA

    Jack Y. Vanderhoek

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