Anti-Idiotypic Vaccines

1. Front Matter

   Pages i-xii

   PDF

2. Some Thoughts on the Future of Idiotypic Vaccines

   • M. Brait, J. Tassignon, J. Ismaili, J. Marvel, K. Meek, O. Leo et al.

   Pages 1-7

3. Stimulation of Lymphocytic Clones by Anti-Idiotypic Antibodies: Basis for Development of Idiotypic Vaccines

   • Richard Bowen, Constantin Bona

   Pages 8-21

4. Small Human VH Gene Families Show Remarkably Little Polymorphism

   • Carol Williams, Linda Weigel, Inaki Sanz, J. Donald Capra

   Pages 22-30

5. Anti-Idiotypic Vaccines for Carbohydrate Antigens

   • Kathryn E. Stein

   Pages 31-41

6. Characterization of Idiotypic Reagents as Antigen Surrogates of a Human Tumor-Associated Antigen

   • Giovanna Viale, Antonio G. Siccardi

   Pages 42-54

7. Anti-Idiotypic Tumor Vaccines

   • Heinz Köhler, Sybille Müller

   Pages 55-72

8. Anti-Idiotypic Antibodies as Potential Viral Vaccines

   • Ronald Q. Warren, Ronald C. Kennedy

   Pages 73-91

9. Utilization of Anti-Idiotypic Antibodies as Molecular Probes of Virus—Receptor Interaction

   • David B. Weiner, Daniel E. McCallus, William V. Williams, Mark I. Greene

   Pages 92-106

10. Anti-Idiotypic Antibodies: An Alternative Approach to Immunoprophylaxis Against Parasites

    • Jean-Marie Grzych, Florence Velge-Roussel, André Capron

    Pages 107-122

11. Idiotype Vaccines by Antibody Engineering: Structural and Functional Considerations

    • Maurizio Zanetti, Rosario Billetta, Maurizio Sollazzo

    Pages 123-137

12. Back Matter

    Pages 138-139

    PDF

Vaccines have historically been considered to be the most cost-effective method for preventing communicable diseases. It was a vaccine~hat enabled global eradication of the dreaded disease smallpox. Mass immunization of children forms the anchor of the strategy of the World Health Organization (WHO) to attain "health for all" status by the year 2000. Vaccinology is undergoing a dimensional change with the advances that have taken place in immunology and genetic engineering. Vaccines that confer short or inadequate immunity or that have side effects are being replaced by better vaccines. New vaccines are being developed for a variety of maladies. Monoclonal antibodies and T cell clones have been employed to delineate the immunodeterminants on microbes, an approach elegantly complemented by computer graphics and molecular imaging techniques. Possibilities have opened for obtaining hitherto scarce antigens of parasites by the DNA recombinant route. Better appreciation of the idiotypic network has aroused research on anti-idiotypic vaccines. Solid-phase synthesis of peptides is leading to an array of synthetic vaccines, an approach that is expected to attain its full potential once the sequences activating suppressor cells are discovered and the rules for presentation of antigens to T and B cells are better worked out. A new breed of vaccines is on the horizon that seeks to control fertility.

• Antigen
• cell
• genes
• parasite
• parasites
• research
• vaccine

• Paris Cedex 15, France

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