Overview
- Editors:
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Abul K. Abbas
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Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
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Richard A. Flavell
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Section of Immunobiology, Yale University School of Medicine, New Haven, USA
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Table of contents (17 chapters)
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Autoimmunity
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- Charles A. Janeway Jr., Florence Susan Wong, Sylvie Guerder, Eva-Pia Reich, Irene Visintin, Richard A. Flavell
Pages 3-15
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- Jacques F. A. P. Miller, William R. Heath, Janette Allison
Pages 16-21
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- Günter J. Hämmerling, Judith Alferink, Iris Ferber, Andreas Limmer, Bernd Arnold
Pages 22-28
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- Joel D. Taurog, Robert E. Hammer
Pages 44-50
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Autoimmunity, Infections
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- Iqbal S. Grewal, Jianchao Xu, Richard A. Flavell
Pages 53-68
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- Ruby Quartey Papafio, Don Healey, Lorraine O’reilly, Patricia Hutchings, Sue Day, Anne Cooke
Pages 82-88
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Cytokines, Co-Stimulators, Tumor Immunity
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Front Matter
Pages 117-117
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- Michael P. Sethna, Luk Van Parijs, Arlene H. Sharpe, Gordon J. Freeman, Abul K. Abbas
Pages 101-106
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- Frank Borriello, Elizabeth A. Tivol, Gordon J. Freeman, Arlene H. Sharpe
Pages 107-120
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- Myung-Shik Lee, Nora Sarvetnick
Pages 121-128
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- Matthew Krummel, James P. Allison
Pages 138-146
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Cytokine Deletions
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Front Matter
Pages 147-147
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- Alexander Kratz, Donna M. Barten, Antonio Campos-Neto, Nancy H. Ruddle
Pages 149-153
About this book
This book contains the proceedings of the Serono Symposia USA interna tional symposium on Genetic Models of Immune and Inflammatory Dis eases held on October 20 to 23, 1994, in Savannah, Georgia. The advent of methods for introducing genes into the germlines of mice, and for targeted disruption of particular genes by homologous recombination, has provided scientists in many disciplines with an extraordinarily powerful set of analyti cal tools. Some of the most informative applications of transgenic and gene knockout technology have been in studies of lymphocyte development and activation. The goal of this symposium was to bring together investigators using these genetic approaches for analyzing the immune system, with a view to defining common themes and novel directions. Transgenic mice have a wide variety of important applications in immu nology. Defined proteins can be expressed in selected tissues throughout development, thus acquiring the essential characteristic of "self" antigens. Such models have been used to study how immune responses to these artificially created "self" antigens are controlled. Antigen receptors of lym phocytes have been expressed as transgenes, and because lymphocytes are endowed with the unique property of allelic exclusion, such transgenic mice become essentially monospecific. Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi cal response modifiers.
Editors and Affiliations
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Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA
Abul K. Abbas
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Section of Immunobiology, Yale University School of Medicine, New Haven, USA
Richard A. Flavell
