Whole Organ Approaches to Cellular Metabolism

1. Front Matter

   Pages i-xxi

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Modeling in the Analysis of the Processes of Uptake and Metabolism in the Whole Organ

      • James B. Bassingthwaighte, Carl A. Goresky, John H. Linehan

      Pages 3-27

3. Mechanisms of Endothelial Transport, Exchange, and Regulation

   1. Front Matter

      Pages 29-29

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   2. Transport Functions of the Glycocalyx, Specific Proteins, and Caveolae in Endothelium

      • Jan E. Schnitzer

      Pages 31-69

   3. Study of Blood Capillary Permeability with the Rete Mirabile

      • Eugenio A. Rasio, Moïse Bendayan, Carl A. Goresky

      Pages 71-90

   4. Interactions Between Bovine Adrenal Medulla Endothelial and Chromaffin Cells

      • Fernando F. Vargas, Soledad Calvo, Raul Vinet, Eduardo Rojas

      Pages 91-107

   5. Studies of the Glomerular Filtration Barrier: Integration of Physiologic and Cell Biologic Experimental Approaches

      • Melvin Silverman

      Pages 109-133

   6. Endothelial Barrier Dynamics: Studies in a Cell-Column Model of the Microvasculature

      • Frederick R. Haselton

      Pages 135-159

4. Metabolism in the Heart and Skeletal Muscle

   1. Front Matter

      Pages 161-161

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   2. Strategies for Uncovering the Kinetics of Nucleoside Transport and Metabolism in Capillary Endothelial Cells

      • James B. Bassingthwaighte, Keith Kroll, Lisa M. Schwartz, Gary M. Raymond, Richard B. King

      Pages 163-188

   3. Norepinephrine Kinetics in Normal and Failing Myocardium: The Importance of Distributed Modeling

      • Colin P. Rose

      Pages 189-203

   4. Metabolic Response Times: A Generalization of Indicator Dilution Theory Applied to Cardiac O2 Consumption Transients

      • Johannes H.G.M. van Beek

      Pages 205-234

   5. Quantitative Assessment of Sites of Adenosine Production in the Heart

      • Andreas Deussen

      Pages 235-259

   6. Role of Capillary Endothelial Cells in Transport and Metabolism of Adenosine in the Heart: An Example of the Impact of Endothelial Cells on Measures of Metabolism

      • Keith Kroll, James Bassingthwaighte

      Pages 261-275

   7. Distribution of Intravascular and Extravascular Resistances to Oxygen Transport

      • Aleksander S. Popel, Tuhin K. Roy, Abhijit Dutta

      Pages 277-293

5. Metabolism in the Liver

   1. Front Matter

      Pages 295-295

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   2. Liver Cell Entry In Vivo and Enzymic Conversion

      • Carl A. Goresky, Glen G. Bach, Andreas J. Schwab, K. Sandy Pang

      Pages 297-324

   3. Probing the Structure and Function of the Liver with the Multiple-Indicator Dilution Technique

      • K. Sandy Pang, Carl A. Goresky, Andreas J. Schwab, Wanping Geng

      Pages 325-367

   4. A Generalized Mathematical Theory of the Multiple-Indicator Dilution Method

      • Andreas J. Schwab

      Pages 369-388

The field of capillary-tissue exchange physiology has been galvanized twice in the past 25 years. A 1969 conference at the National Academy of Sciences in Copenhagen resulted in the book Capillary Permeability: The Transfer of Mole­ cules and Ions Between the Capillary Blood and the Tissue (Crone and Lassen, 1970). It focused on the physiochemical aspects of transcapillary water and solute transport. The field has matured considerably since. This volume was designed as the successor to the 1970 book, and was created at a gathering of the authors at McGill University. It too captures the breadth of a field that has been dramatically enriched by numerous technical and conceptual advances. In 1970 it was already known that the capillary wall was not merely a "cellophane bag" exerting steric hindrances on solute particles. Instead, the endothelial surface was recognized as the site of binding reactions and permeation by passive or carrier-mediated trans­ port. Furthermore, the cells of the blood could traverse evanescent wide openings in the "zippered" clefts. Today, research priorities have turned more to cell-cell interactions, toward understanding the utility of the gap junctional connections between endothelial cells and neighboring smooth muscle cells, neuronal twigs, and the parenchymal cells of organs. New discoveries in the past few years have revealed the critical importance of the close relationships between the endothelial cells and the parenchymal cells.

• Vivo
• biomedical engineering
• biomedical engineers
• cell
• cellular processes
• chemistry
• endothelium
• enzyme
• metabolism
• physiology
• protein
• regulation
• resistance
• skeletal muscle
• tissue

• Department of Bioengineering, University of Washington, Seattle, USA

  James B. Bassingthwaighte

• Biomedical Engineering Department, Marquette University, Milwaukee, USA

  John H. Linehan

• Division of Gastroenterology Department of Medicine, McGill University School of Medicine, Montreal, Canada

  Carl A. Goresky

Policies and ethics