Signal Transduction in Mast Cells and Basophils

1. Front Matter

   Pages i-xx

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2. Section I

   1. Front Matter

      Pages 1-1

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   2. Signals in the Regulation of Mast Cell Growth and Development: A Perspective

      • Stephen J. Galli

      Pages 3-10

   3. The Regulation of Mast Cell and Basophil Development by the Kit Ligand, SCF, and IL-3

      • Stephen J. Galli, Mindy Tsai, Chris S. Lantz

      Pages 11-30

   4. The c-kit Receptor and the mi Transcription Factor: Two Important Molecules for Mast Cell Development

      • Yukihiko Kitamura, Eiichi Morii, Tomoko Jippo

      Pages 31-38

   5. Mouse and Rat Models of Mast Cell Development

      • Guang W. Wong, Daniel S. Friend, Richard L. Stevens

      Pages 39-53

   6. Factors That Affect Human Mast Cell and Basophil Growth

      • Lixin Li, Xiao-Tong Zhang, Steven A. Krilis

      Pages 54-65

   7. Signal Transduction by Cytokines

      • John W. Schrader

      Pages 66-84

   8. Mast Cell Apoptosis and Its Regulation

      • Yoseph A. Mekori, Karin Hartmann, Dean D. Metcalfe

      Pages 85-94

3. Section II

   1. Front Matter

      Pages 95-95

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   2. Early Signals in Mast Cell Activation: A Perspective

      • Henry Metzger

      Pages 97-101

   3. FcεRI Signaling in Specialized Membrane Domains

      • Kenneth A. Field, David Holowka, Barbara Baird

      Pages 102-114

   4. Regulation and Function of Protein Tyrosine Kinase Syk in FcεRI-Mediated Signaling

      • Reuben P. Siraganian, Juan Zhang, Teruaki Kimura

      Pages 115-133

   5. The Role of Protein Phosphatases in Cell Signaling by the High-Affinity Receptor for Immunoglobulin E

      • Matthew J. Peirce

      Pages 134-151

   6. Protein Kinase C and Early Mast Cell Signals

      • Patrick G. Swann, Sandra Odom, Juan Rivera

      Pages 152-170

   7. Mast Cell Inhibitory Receptors of the Immunoglobulin Superfamily

      • Howard R. Katz

      Pages 171-177

4. Section III

   1. Front Matter

      Pages 179-179

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   2. Signaling Pathways That Regulate Effector Function: Perspectives

      • Reuben P. Siraganian

      Pages 181-190

   3. Phosphoinositide-Derived Second Messengers in FcεRI Signaling: PI-3 Kinase Products Control Membrane Topography and the Translocation and Activation of PLC-γ1 in Antigen-Stimulated Mast Cells

      • Bridget S. Wilson, Sheryll A. Barker, Timothy E. Graham, Janet R. Pfeiffer, Janet M. Oliver

      Pages 191-206

   4. Phospholipase D and Its Role in Mast Cells

      • David S. Cissel, Paul F. Fraundorfer, Michael A. Beaven

      Pages 207-226

Mast cells and basophils are responsible for inflammatory and allergic reactions. As such, the signals that generate these responses and how their pathways of action work are the focus of much present day research into allergy and inflammation. This book focuses primarily on the molecular mechanisms that govern mast cell and basophil cell biology and function, as well as providing a comprehensive summary of the field of signal transduction and also giving insights into areas that have therapeutic potential. The book provides detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide the reader with an up-to-date account of a topic where the rapid progress makes conventional information gathering difficult.

• Activation
• apoptosis
• biology
• cell
• cell biology
• cytokine
• immunoglobulin
• membrane
• metabolism
• molecular mechanisms
• morphology
• protein
• regulation
• signal transduction
• transcription

• Department of Biochemistry, Haddasah Medical School, Hebrew University, Jerusalem, Israel

  Ehud Razin

• Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bathesda, USA

  Juan Rivera

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