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Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine

  • Book
  • © 2000

Overview

Editors:
  1. Johnny Huard

    1. Growth and Development Laboratory Department of Orthopaedic Surgery and Molecular Genetics and Biochemistry, Chilren’s Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, USA

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  2. Freddie H. Fu

    1. Department of Orthopaedic Surgery Musculoskeletal Research Center Center for Sports Medicine, University of Pittsburgh, Pittsburgh, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Methods in Bioengineering (MB)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Background

    1. Front Matter

      Pages 1-1
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    2. Gene Therapy in Orthopaedics

      • Christian Lattermann, Freddie H. Fu
      Pages 3-14

    3. The Use of Different Vectors and Strategies for Gene Transfer to the Musculoskeletal System

      • Johnny Huard
      Pages 15-40

  3. Gene Therapy Applications for the Musculoskeletal System

    1. Front Matter

      Pages 41-41
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    2. Regional Gene Therapy for Hard Tissues

      • Jay R. Lieberman
      Pages 43-56

    3. Potential Applications of Gene Therapy to the Treatment of Spinal Disorders

      • Kotaro Nishida, James D. Kang, Scott D. Boden, Lars G. Gilbertson, Jun-Kyo Suh, Paul D. Robbins et al.
      Pages 57-73

    4. The Development of Approaches Based on Gene Therapy to Improve Muscle Healing Following Injury

      • Jacques Ménétrey, Channarong Kasemkijwattana, Charles S. Day, Patrick Bosch, Morey S. Moreland, Freddie H. Fu et al.
      Pages 74-88

    5. Nonviral Gene Therapy: Application in the Repair of Osteochondral Articular Defects

      • Randal S. Goomer, David Amiel
      Pages 89-105

    6. The Potential of Gene Therapy for Osteogenesis Imperfecta

      • Christopher Niyibizi, Patrick N. Smith, Joel Greenberger
      Pages 106-125

    7. The Role of Nitric Oxide as a Candidate Molecule for Gene Therapy in Sports Injuries

      • Scott A. Rodeo, Kazutaka Izawa
      Pages 126-139

  4. Tissue Engineering in Orthopaedics and Sports Medicine

    1. Front Matter

      Pages 141-141
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    2. Stem Cells and Tissue Engineering

      • Henry E. Young
      Pages 143-173

    3. Tissue Engineering of Ligament Healing

      • Savio L-Y. Woo, Nobuyoshi Watanabe, Kevin A. Hildebrand
      Pages 174-195

    4. Muscle-Based Tissue Engineering for Orthopaedic Applications

      • Douglas S. Musgrave, Charles S. Day, Patrick Bosch, Jacques Ménétrey, Channarong Kasemkijwatanna, Morey S. Moreland et al.
      Pages 196-212

    5. Application of Tissue Engineering to Cartilage Repair

      • Jun-Kyo Suh, Freddie H. Fu
      Pages 213-229

  5. Hurdles and Development of New Vectors for Gene Therapy and Tissue Engineering

    1. Front Matter

      Pages 231-231
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    2. Immune Reaction Following Cell and Gene Therapy

      • Jacques P. Tremblay
      Pages 233-244

    3. Vectors for Gene Transfer to Joints

      • Paul D. Robbins, Steven C. Ghivizzani, Joseph C. Glorioso, Christopher H. Evans
      Pages 245-259

    4. Adeno—Associated Virus (AAV) Vectors for Musculoskeletal Gene Transfer

      • Xiao Xiao, Ryan Pruchnic, Juan Li, Johnny Huard
      Pages 260-273
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Keywords

About this book

This book has been written in response to the many physicians and scien­ tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.

Editors and Affiliations

  • Growth and Development Laboratory Department of Orthopaedic Surgery and Molecular Genetics and Biochemistry, Chilren’s Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, USA

    Johnny Huard

  • Department of Orthopaedic Surgery Musculoskeletal Research Center Center for Sports Medicine, University of Pittsburgh, Pittsburgh, USA

    Freddie H. Fu

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