Advances in Blood Substitutes

1. Front Matter

   Pages i-xiv

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2. Blood Substitutes: 1996 in the Literature

   • Robert M. Winslow

   Pages 1-18

3. Blood Substitutes and the Intestinal Microcirculation: Extravasation and Ultrastructural Alterations

   • Ann Baldwin

   Pages 19-37

4. A Discussion of Pharmacoeconomics Applied to Blood Substitutes

   • Pamela Bassett

   Pages 38-45

5. Tumor Microcirculation: Role in Drug and Nutrient Delivery

   • Rakesh K. Jain

   Pages 46-70

6. The Pressor Effect of Hemoglobin-Good or Bad?

   • Robert J. Przybelski, Elaine K. Daily, B. S. FCCM, Marvin L. Birnbaum

   Pages 71-90

7. Perflubron-based Emulsion: Efficacy as Temporary Oxygen Carrier

   • Stephen F. Flaim

   Pages 91-132

8. The Other Blood Substitute:Antigenically Inert Erythrocytes

   • Mark D. Scott, Kari L. Murad, John W. Eaton

   Pages 133-150

9. Hemoglobin Encapsulation With Polyethylene Glycol-modified and Unmodified Vesicles: Systemic and Microvascular Hemodynamics at 80% Blood Substitution

   • Hiromi Sakai, Amy G. Tsai, Marcos Intaglietta, Eishun Tsuchida

   Pages 151-166

10. Hemoglobin Oxygen Affinity and the Design of Red Cell Substitutes

    • Robert M. Winslow, Kim D. Vandegriff

    Pages 167-188

11. The Mechanism of Tissue Oxygenation and the Design of Oxygen Carrying Plasma Expanders

    • Amy G. Tsai, Barbara Friensenecker, Hiromi Sakai, Heinz Kerger, Marcos Intaglietta

    Pages 189-206

12. Colloid Osmotic Effects of Hemoglobin-based Oxygen Carriers

    • Kim D. Vandegriff, Ronald J. Rohlfs, Robert M. Winslow

    Pages 207-232

13. Dextran-Hemoglobin

    • Sheung-Pun Tsai, J. Tze-Fei Wong

    Pages 233-250

14. Modification of Molecules and Particles With Polyethylene Glycol (PEG): Long-circulating Pharmaceuticals

    • Vladimir P. Torchilin

    Pages 251-297

15. The Reaction of Nitric Oxide with Cell-free Hemoglobin Based Oxygen Carriers: Physiological Implications

    • Ronald J. Rohlfs, Kim D. Vandegriff, Robert M. Winslow

    Pages 298-327

16. Back Matter

    Pages 328-338

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Each chapter of this volume is a contribution from an expert in the field, chosen by the editors to contribute to the 1997 "Current Issues in Blood Substitute Research and Development" course given in San Diego, March 17-19. The contributors were selected because of their expertise in areas which the editors believe to be critical to the advancement of the field, and which reflect activity in "hot" areas of relevant research. While there is a continuity in style for the annual course, each year brings changes in emphasis and content. In previous years, we were often not able to provide time for participants to present their views and opinions. Consequently, this year we encouraged discussion after each presentation. These sessions were recorded, transcribed, and are printed with the chapters herein. We believe that the product is very close to the capturing this year's course in print, and trust readers will enjoy reading the always candid and often provocative remarks from the audience. The price paid for inclusion of the discussion transcriptions was a delay in publication. Each author was allowed to edit his/her discussion section as well as the final version of the chapters prior to publication. The changes are mainly for grammar, and we tried, when possible, not to alter the conversational style of these interchanges.

• Antigen
• Blood Substitutes
• Medical Challenges
• Urgent Blood Transfusion
• transcription

• School of Medicine, University of California, San Diego, USA

  Robert M. Winslow, Kim D. Vandegriff

• Dept. of Bioengineering, University of California, San Diego, USA

  Marcos Intaglietta

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