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The P2 Nucleotide Receptors

  • Book
  • © 1998

Overview

Editors:
  1. John T. Turner

    1. Department of Pharmacology, University of Missouri-Columbia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Gary A. Weisman

    1. Department of Pharmacology, University of Missouri-Columbia, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Jeffrey S. Fedan

    1. Physiology Section, National Institute for Occupational Safety and Health, Morgantown, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: The Receptors (REC)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xi
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  2. Historical Perspectives of P2 Nucleotide Receptors

    1. Front Matter

      Pages 1-1
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    2. History of Extracellular Nucleotides and Their Receptors

      • Geoffrey Burnstock
      Pages 3-40

  3. Pharmalogical and Molecular Characterization of P2 Nucleotide Receptors

    1. Front Matter

      Pages 41-41
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    2. P2X Receptors

      • Richard J. Evans, Annmarie Surprenant, R. Alan North
      Pages 43-61

    3. The Cloning and Expression of G Protein-Coupled P2Y Nucleotide Receptors

      • Gary A. Weisman, Fernando A. Gonzalez, Laurie Erb, Richard C. Garrad, John T. Turner
      Pages 63-79

    4. Structure Activity Relationships of P2 Receptor Agonists and Antagonists

      • Kenneth A. Jacobson, Yong-Chul Kim, Emidio Camaioni, A. Michiel van Rhee
      Pages 81-107

    5. Pharmacological Selectivities of Molecularly Defined Subtypes of P2Y Receptors

      • T. Kendall Harden, Robert A. Nicholas, Joel B. Schachter, Eduardo R. Lazarowski, José L. Boyer
      Pages 109-134

    6. P2 Receptor Modeling and Identification of Ligand Binding Sites

      • A. Michiel van Rhee, Kenneth A. Jacobson, Richard Garrad, Gary A. Weisman, Laurie Erb
      Pages 135-166

  4. Mechanisms of P2 Nucleotide Receptor Action

    1. Front Matter

      Pages 167-167
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    2. Nucleotide Receptors Coupling to the Phospholipase C Signaling Pathway

      • Jean-Marie Boeynaems, Didier Communi, Rodolphe Janssens, Serge Motte, Bernard Robaye, Sabine Pirotton
      Pages 169-183

    3. Cyclic AMP and Tyrosine Kinase Cascades in the Regulation of Cellular Function by P2Y Nucleotide Receptors

      • Michael R. Boarder
      Pages 185-209

    4. Characteristics of Ligand-Gated Ion Channel P2 Nucleotide Receptors

      • Charles Kennedy, Suzanne E. Hickman, Samuel C. Silverstein
      Pages 211-230

    5. Cell Responses Initiated by Ecto-Kinases

      • Jeffrey S. Fedan
      Pages 231-255

  5. Physiological and Therapeutic Roles of P2 Nucleotide Receptors

    1. Front Matter

      Pages 257-257
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    2. Functions of Extracellular Nucleotides in Peripheral and Central Neuronal Tissues

      • Eugene M. Silinsky, Ivar von Kügelgen, Andrew Smith, David P. Westfall
      Pages 259-290

    3. Role of Purinoceptors in the Regulation of Lung Surfactant Secretion

      • Seamus A. Rooney
      Pages 291-318

    4. The Role of Nucleotide Receptors in the Cardiovascular System

      • Sabine Pirotton, Claude Desgranges, Guy Vassort, Jean-Marie Boeynaems
      Pages 319-359

    5. Physiological Roles for P2 Receptors in Platelets, Visceral Smooth Muscle, and the Immune and Endocrine Systems

      • Susanna Hourani, Francesco Di Virgilio, Marie-Madeleine Loubatières-Mariani
      Pages 361-411

    6. Therapeutic Applications for Nucleotides in Lung Disease

      • Scott H. Donaldson, Richard C. Boucher
      Pages 413-424
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Keywords

About this book

A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors. The authoritative contributions cover the major aspects of these receptors, describing the relationships between physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. They also illuminate how P2 receptor structures contribute to their function, including the physical differences underlying the pharmacological and functional variations among P2 receptor subtypes.









Reviews

"This book is...very timely...essential reading...really useful and encyclopaedic information."-Journal of Chemical Neuroanatomy

Editors and Affiliations

  • Department of Pharmacology, University of Missouri-Columbia, USA

    John T. Turner, Gary A. Weisman

  • Physiology Section, National Institute for Occupational Safety and Health, Morgantown, USA

    Jeffrey S. Fedan

Bibliographic Information

  • Book Title: The P2 Nucleotide Receptors

  • Editors: John T. Turner, Gary A. Weisman, Jeffrey S. Fedan

  • Series Title: The Receptors

  • DOI: https://doi.org/10.1007/978-1-4612-1800-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1998

  • Hardcover ISBN: 978-0-89603-425-9Published: 24 October 1997

  • Softcover ISBN: 978-1-4612-7289-2Published: 11 October 2012

  • eBook ISBN: 978-1-4612-1800-5Published: 06 December 2012

  • Series ISSN: 1048-6909

  • Series E-ISSN: 2524-6488

  • Edition Number: 1

  • Number of Pages: XI, 440

  • Topics: Cell Biology

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