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Neoplastic Transformation in Human Cell Culture

Mechanisms of Carcinogenesis

  • Book
  • © 1991

Overview

Editors:
  1. Johng S. Rhim

    1. Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Anatoly Dritschilo

    1. Department of Radiation Medicine, Georgetown University Medical Center, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Experimental Biology and Medicine (EBAM, volume 25)

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Table of contents (38 chapters)

  1. Front Matter

    Pages i-xxxi
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  2. Preneoplastic Events

    1. Front Matter

      Pages 1-1
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    2. Comparison of Human Versus Rodent Cell Transformation: Importance of Cell Aging

      • J. Carl Barrett
      Pages 3-13

    3. Deficient DNA Repair, an Early Step in Neoplastic Transformation of Human Cells in Culture

      • K. K. Sanford, R. Parshad
      Pages 15-23

    4. Use of Immortalized Human Keratinocytes for the Study of Squamous Differentiation and Mutagenesis

      • B. Lynn Allen-Hoffmann, Nader Sheibani, Jill S. Hatfield, Johng S. Rhim
      Pages 25-34

    5. Studies of Mutagen-Activated Genes which Confer Anchorage-Independence: the c-sis Gene as a Model

      • William E. Fahl, William H. Brondyk, Hua-Ming Jin, Craig W. Stevens, Carsten-Peter Carstens, Gregory C. Kujoth et al.
      Pages 35-46

    6. Cytoskeletal Changes in Human Transformed Cells: Studies on HOS Cells

      • C. Chandra Kumar, Cecile Chang, Johng Rhim
      Pages 47-56

    7. Polyamine Metabolism in Human Epidermal Keratinocytes Transformed with AD12-SV40, HPV16-DNA and K-ras Oncogene

      • S. Beninati, S. C. Park, M. Piacentini, J. S. Rhim, S. I. Chung
      Pages 57-64

  3. Radiation Transformation and Oncogenes

    1. Front Matter

      Pages 65-65
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    2. Transformation of Human Diploid Fibroblasts by Radiation and Oncogenes

      • J. B. Little, L.-N. Su, Y. Kano
      Pages 67-79

    3. Ionizing Radiation-Mediated Protein Kinase C Activation and Gene Expression

      • Dennis E. Hallahan, Matthew L. Sherman, Donald Kufe, Ralph R. Weichselbaum
      Pages 81-92

    4. Detection of Transforming Genes from Radiation Transformed Human Epidermal Keratinocytes by a Tumorigenicity Assay

      • P. Thraves, S. Reynolds, Z. Salehi, W. K. Kim, J. H. Yang, J. S. Rhim et al.
      Pages 93-101

    5. Neoplastic Transformation of Human Epithelial Cells by Ionizing Radiation

      • T. C. Yang, M. R. Stampfer, J. S. Rhim
      Pages 103-111

    6. Effects of Ionizing Radiation on Human Papillomavirus Immortalized Human Bronchial Epithelial Cells

      • James C. Willey, Jim Greene, Alberec Bressoud, Peter Cerutti, Tom Hei, Nancy Wang et al.
      Pages 113-117

    7. Biochemical Purification of a CSF-1 like Molecule Released during Malignant Transformation of IL-3 Dependent Hematopoietic Progenitor cell lines Cocultivated with Gamma Irradiated Clonal Marrow Stromal cell lines

      • J. S. Greenberger, J. Lief, P. Anklesaria, M. A. Sakakeeny, D. English, D. Crawford et al.
      Pages 119-123

    8. An Inherited P53 Point Mutation in a Cancer Prone Family with Li-Fraumeni Syndrome

      • S. Srivastava, Z. Zou, K. Pirollo, D. Tong, V. Sykes, K. Devadas et al.
      Pages 125-134

    9. p53, a Direct Target of Mutational Activation by Chemical Carcinogens?

      • M. Nagarajan, M. Bowman, L. Rigby, J. S. Rhim, S. Sukumar
      Pages 135-139

  4. Viral Transformation and Oncogenes

    1. Front Matter

      Pages 141-141
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    2. The HIV tat Gene Induces Epidermal Hyperplasia in vivo and Transforms Keratinocytes in vitro

      • Jonathan A. Rhim, Jonathan Vogel, Chang-Min Kim, Gilbert Jay, Johng S. Rhim
      Pages 143-152

    3. Immortalization and Tumorigenic Transformation of Normal Human Cervical Epithelial Cells Transfected with Human Papillomavirus DNAs

      • Craig D. Woodworth
      Pages 153-161
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Keywords

About this book

The role of carcinogenic agents in the deveolopment of human cancers is now being defined using a variety of human cells as experi­ mental model systems. A workshop on "neoplastic transformation in human cell systems in vitro: mechanisms of carcinogenesis" was held at the Georgetown University Medical Center, Washington, DC, on April 25-26, 1991. The aims of the workshop were to present the state-of-the­ art in the transformation of human cells in culture, as well as to provide insight into the molecular and cellular changes involved in the conver­ sion of normal cells to a neoplastic state of growth. The following topics were closely related to the theme of the workshops: 1. Derivation of in vitro model systems (epithelial, fibroblastic, and hematopoietic). 2. Factors modulating cellular transformation. 3. Usefulness of defined in vitro model systems for viral, chemical, and radiation carcinogenesis. 4. Multistep nature of human cell carcinogenesis. 5. Role of activated and suppressor oncogenes in neoplastic trans­ formation. The workshop was organized by J. S. Rhim and A. Dritschilo (cochairmen), G. Jay, J. little, M. McCormick, R Tennant, and R R Weischelbaum. There were 32 speakers, 30 poster presentations, and about 190 participants.

Reviews

...should be a part of any departmental library serving virologists, cell biologists, pathologists, and other scientists interested in malignant cell growth.-Quarterly Review of Biology

Editors and Affiliations

  • Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, USA

    Johng S. Rhim

  • Department of Radiation Medicine, Georgetown University Medical Center, USA

    Anatoly Dritschilo

Bibliographic Information

  • Book Title: Neoplastic Transformation in Human Cell Culture

  • Book Subtitle: Mechanisms of Carcinogenesis

  • Editors: Johng S. Rhim, Anatoly Dritschilo

  • Series Title: Experimental Biology and Medicine

  • DOI: https://doi.org/10.1007/978-1-4612-0411-4

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1991

  • Hardcover ISBN: 978-0-89603-227-9Published: 10 December 1991

  • Softcover ISBN: 978-1-4612-6750-8Published: 13 October 2012

  • eBook ISBN: 978-1-4612-0411-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXXI, 396

  • Topics: Pathology

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