Molecular Neurovirology

1. Front Matter

   Pages i-xx

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2. DNA Viruses

   1. Front Matter

      Pages 1-1

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   2. Herpes Simplex Viruses, Central Nervous System, and Encephalitis

      • Bernard Roizman, Leonard J. Kaplan

      Pages 3-23

   3. The Molecular Biology of JC Virus, Causative Agent of Progressive Multifocal Leukoencephalopathy

      • Richard J. Frisque, Frank A. White III

      Pages 25-158

3. RNA Viruses with DNA Step in Replication

   1. Front Matter

      Pages 159-159

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   2. Molecular Basis of Neurologic Disorders Induced by a Mutant, ts1, of Moloney Murine Leukemia Virus

      • Paul K. Y. Wong, P. H. Yuen

      Pages 161-197

   3. Pathogenesis of Murine Spongiform Myeloencephalopathy Induced by a Murine Retrovirus

      • Paul Jolicoeur, Claude Gravel, Denis G. Kay

      Pages 199-224

   4. Biological and Molecular Aspects of HTLV-1-Associated Diseases

      • Michael I. Nerenberg

      Pages 225-247

4. RNA Viruses with Positive-Sense Genome and No DNA Step in Replication

   1. Front Matter

      Pages 249-249

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   2. Molecular Mechanisms of Poliovirus Pathogenesis

      • Akio Nomoto, Satoshi Koike

      Pages 251-281

   3. Determinants of Neurological Disease Induced by Theiler’s Murine Encephalomyelitis Virus

      • Raymond P. Roos, Nancy Casteel

      Pages 283-318

   4. Molecular Basis of Neuropathogenicity of Mouse Hepatitis Virus

      • Michael M. C. Lai, Stephen A. Stohlman

      Pages 319-348

   5. Sindbis Virus

      • Diane E. Griffin, Pamela C. Tucker, Steven L. Novick

      Pages 349-375

   6. Pathogenesis of Age-Dependent Poliomyelitis of Mice

      • Christopher H. Contag, John T. Harty, Peter G. W. Plagemann

      Pages 377-415

5. RNA Viruses with Negative-Sense Genome and No DNA Step in Replication

   1. Front Matter

      Pages 417-417

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   2. Molecular Aspects of Measles-Virus-Induced Central Nervous System Diseases

      • Sibylle Schneider-Schaulies, Volker ter Meulen

      Pages 419-448

   3. Molecular Approaches to the Study of Bunyavirus Encephalitis

      • Francisco Gonzalez-Scarano, Michael Endres, David R. Jacoby, Christian Griot, Neal Nathanson

      Pages 449-469

6. Unconventional Agents

   1. Front Matter

      Pages 471-471

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   2. Molecular Biological Studies of Prion Disorders in Humans and Animals

      • Stanley B. Prusiner

      Pages 473-501

   3. Infectious Amyloidoses

      • D. Carleton Gajdusek

      Pages 503-523

Neurovirology, the study of viral infection of the ner­ vous system, has evolved at the interface of three of the most rapidly unfolding fields of investigation-neurobiology, vi­ rology, and immunology. In all three, increasing knowledge about the molecular structure of surface receptors, how in­ tracellular messages are transmitted, and how diversity is regulated genetically is provided, along with the techniques of molecular biology. This promises to give us knowledge not only about the process of infection and the complex host and viral determinants of neuroinvasiveness and neurovirulence, but eventually it will provide the background from which to engineer vaccines and to devise novel therapeutic agents. Animal virology and molecular biology developed quite independently from different origins. Animal virology was originally the province of the pathologists, and by clinical observation and histological preparations, they tried to ex­ plain the incubation period, the pathways of virus spread, and the mechanisms of disease. Molecular virology grew out of biochemistry, particularly through studies of bacterio­ phage, with emphasis on the physical and chemical structure of viruses and the sequences of biochemical events during the replicative cycle in cells.

• AIDS
• HIV
• Nervous System
• RNA
• central nervous system
• hepatitis
• immunodeficiency
• immunology
• infection
• information
• molecular biology
• neurology
• pathogenesis
• virology
• virus

To bring together a team of distinguished specialists to discuss current aspects of neurovirology was an excellent idea. This ambitious and...successful review examines virus-induced cell injury and neurological disease ....Referencing is comprehensive and up-to-date, and publication is both timely and welcome.-The Lancet

• University of Chicago Medical Center, Chicago, USA

  Raymond P. Roos

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