Overview
- Editors:
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Boris Draznin
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University of Colorado Health Sciences Center, Denver, USA
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Derek LeRoith
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National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, USA
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Table of contents (16 chapters)
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Front Matter
Pages i-xiii
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Molecular Mechanisms of Autoimmunity and Genetics of Diabetes
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- Massimo Pietropaolo, George S. Eisenbarth
Pages 1-33
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- Danling Gu, Nora Sarvetnick
Pages 35-47
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- Filippo Calcinaro, Dale R. Wegmann, Kevin J. Lafferty
Pages 69-90
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Molecular and Cellular Aspects of Insulin Synthesis and Secretion
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- Christopher B. Newgard, Sarah Ferber, Christian Quaade, John H. Johnson, Steven D. Hughes
Pages 119-154
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- Mark A. Magnuson, Kevin D. Niswender, Cathleen C. Pettepher
Pages 155-174
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- Guizhu Li, Prabakaran Kesavan, Habiba Najafi, Lijun Wang, Peter Ronner, Donna Berner et al.
Pages 175-193
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- R. Paul Robertson, L. Karl Olson, J. Bruce Redmon, Hui-Jian Zhang, Howard C. Towle
Pages 195-212
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- Deborah L. Bennett, John C. Hutton
Pages 213-248
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- Anjaneyulu Kowluru, Stewart A. Metz
Pages 249-283
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- Joseph S. Dillon, Ming Lu, Michael B. Wheeler, Aubrey E. Boyd III
Pages 285-301
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- Illani Atwater, Manuel Kukuljan, Elia Martha Pérez-Armendariz
Pages 303-332
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- Peter C. Butler, Norman L. Eberhardt, Timothy D. O’Brien
Pages 381-398
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Back Matter
Pages 399-404
About this book
In a rapidly evolving and extremely important area of medical science, it is often difficult for the student, teacher, and researcher to keep abreast of all the important advances. The purpose of Molecular Biology ofDiabetes, Parts I and II is to bring to these individuals the latest knowledge of diabetes-related research in a comprehensive, yet concise manner. To this end, we have assembled chapters, written by most of the world's experts in the field, that we believe compre hensively survey and synthesize a coherent understanding of the subject. Studies of the etiology of type I and type II diabetes are extremely exciting and essential, since we hope to one day prevent the disease using gene therapy. These aspects are covered in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor mality of insulin secretion is believed to be related to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre tion may be the crucial step in the pathogenesis of noninsulin-depen dent diabetes. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mecha nisms of insulin synthesis and secretion. In the last few years, the most rapidly advancing area of research in diabetes has been, in fact, related to insulin action.
Reviews
This is an essential book for a medical library to have, and it is a welcome addition to the library of investigators in the field. Specialists in diabetes will also find this book very useful. - Kevan Herold, MD for Doody's Health Science Book Review Journal
Editors and Affiliations
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University of Colorado Health Sciences Center, Denver, USA
Boris Draznin
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National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, USA
Derek LeRoith
