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ADP-Ribosylation Reactions

  • Conference proceedings
  • © 1992

Overview

Editors:
  1. Guy G. Poirier

    1. Centre de Recherches en Endocrinologie Moleculaire, Le Centre Hospitalier de l’Universite Laval, Canada

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  2. Pierre Moreau

    1. Biochemistry Department Pavillon Vachon, Universite Laval, Canada

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Table of contents (74 papers)

  1. Front Matter

    Pages i-xxxvi
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  2. Molecular Biology

    1. Front Matter

      Pages 1-1
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    2. Structure and function of the human poly(ADP-ribose) polymerase

      • Miguel Molinete, Valérie Schreiber, Frédéric Simonin, Gérard Gradwohl, Josiane Ménissier-de Murcia, Gilbert de Murcia
      Pages 3-13

    3. Cloning of Poly(ADP-ribose) Polymerase cDNA from Lower Eukaryotes

      • Masanao Miwa, Youichi Ozawa, Masako Uchida, Shigeki Kushida, Yoshihiro Ami, Masayuki Matsumura et al.
      Pages 14-19

    4. Molecular Biology of Human Nuclear NAD+: ADPRibosyl-transferase (polymerizing)

      • M. Schweiger, B. Auer, H. Herzog, M. Hirsch-Kauffman, P. Kaiser, K. Flick et al.
      Pages 20-29

    5. Strategies for Studying the Functions of PADPRP Genes on Human Chromosomes 1 and 13

      • Mark E. Smulson
      Pages 30-37

    6. Expression of the DNA-Binding Domain of Human Poly(ADP-Ribose) Polymerase as a Trans-Dominant Inhibitor of Poly(ADP-Ribosyl)ation in Transfected Eucaryotic Cell Lines

      • Jan-Heiner Küpper, Alexander Bürkle
      Pages 38-46

    7. Directed Mutagenesis of Glutamic Acid 988 of Poly(ADP-ribose) Polymerase

      • G. T. Marsischky, M. Ikejima, H. Suzuki, T. Sugimura, H. Esumi, M. Miwa et al.
      Pages 47-52

    8. Chicken poly(ADP-ribose) polymerase. Complete protein sequence deduced from cDNA,comparison with mammalian enzyme sequences

      • Claude P. Niedergang, Jean-Marie Garnier, Jean-Marc Jeltsch, Marie-Elisabeth Ittel
      Pages 53-57

    9. Nuclear poly(ADPR)Polymerase expression and activity in rat astrocytes culture: effects of bFGF

      • Magali G. Chabert, Claude P. Niedergang, Fernand Hog, Mariagrazia Partisani, Paul Mandel
      Pages 58-61

    10. Molecular Cloning of the Rat Poly (ADP-Ribose) Polymerase Gene and Preliminary Characterization of its Promoter and 5’-Flanking Regions

      • Frederic Potvin, Jacques Thibodeau, Guy G. Poirier, Sylvain L. Guérin
      Pages 62-68

    11. Structure and Organization of the Mouse pADPRT Gene

      • H. Berghammer, M. Schweiger, B. Auer
      Pages 69-72

    12. Strategies for Expressing Analogs of PADPRP in Eukaryotic Cells

      • Veronica Kang, Saikh J. Haque, Barry Cherney, Mark Smulson
      Pages 73-76

    13. Expression and Characterization of PADPRP and a Novel Glucocorticoid-PADPRP “Finger Swapped” Protein from Escherichia coli

      • Barry Cherney, Kishor Bhatia, Bushra Chaudhry, Tauseef Butt, Mark Danielsen, Mark Smulson
      Pages 77-80

    14. Tumor Promoters, But Not EGF, Increase Nuclear Poly(ADP-Ribose) Polymerase Gene Expression in Rat Hepatocytes Initiated in Utero with DMN and Cultured After Birth in Low-Calcium Synthetic Medium

      • U. Armato, Lucia Testolin, Marta Menegazzi, Lia Menapace, Maria Ribecco, Alessandra Carcereri DePrati et al.
      Pages 81-85

    15. Expression of the gene for poly(ADP-ribose) polymerase and DNA polymerase beta in rat tissues and in proliferating cells

      • Marta Menegazzi, Alessandra Carcereri De Prati, Tsutomu Ogura, Amedeo Columbano, Giovanna Maria Ledda-Columbano, Palmiro Poltronieri et al.
      Pages 86-91

    16. Expression of poly (ADP-ribose) polymerase in differentiating HL-60 cells

      • Pierre Moreau, Guy Poirier, Scott Kaufmann
      Pages 92-94

  3. Cancer, DNA Repair, and Metabolism

    1. Front Matter

      Pages 95-95
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    2. A Novel Model of Enzymatic Repair of UV-Induced DNA Damage in Human Cells

      • Malcolm C. Paterson, Michel Liuzzi, Anne M. Galloway, John R. A. Chan, Michael V. Middlestadt, Michael Weinfeld et al.
      Pages 97-105

    3. Poly(ADP—Ribose)Polymerase in Xenopus laevis

      • B. Saulier, F. Simonin, G. Gradwohl, G. de Murcia, M. Philippe
      Pages 106-112
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Keywords

About this book

This monograph is dedicated to one of the discoverers of poly(ADP­ ribose), Professor Paul Mandel, from the Centre de Neurochimie in Strasbourg. We would like to congratulate him for his distinguished contributions to the field of poly(ADP-ribosyl)ation and express our gratitude for his support in the last years and particularly for his encouragement for the organization of this meeting. Poly(ADP-ribose) was discovered more than 25 years ago. Since then, excellent progress has been made on the study of the mechanisms of poly(ADP­ ribose) reaction. The last five years have been particularly exciting since the development of various molecular biology techniques has revealed the complex nature of this multifunctional enzyme. Looking at the contributions presented at this meeting, it becomes obvious that more work at the molecular level is needed. Most likely, these experiments will shed some light on the functions of poly(ADP-ribose), but further ~iophysical studies will still be required to fully understand this complex enzymatic system.

Editors and Affiliations

  • Centre de Recherches en Endocrinologie Moleculaire, Le Centre Hospitalier de l’Universite Laval, Canada

    Guy G. Poirier

  • Biochemistry Department Pavillon Vachon, Universite Laval, Canada

    Pierre Moreau

Bibliographic Information

  • Book Title: ADP-Ribosylation Reactions

  • Editors: Guy G. Poirier, Pierre Moreau

  • DOI: https://doi.org/10.1007/978-1-4419-8718-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1992

  • Hardcover ISBN: 978-0-387-97822-2Published: 14 May 1992

  • Softcover ISBN: 978-1-4612-6456-9Published: 09 November 2012

  • eBook ISBN: 978-1-4419-8718-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXXVI, 410

  • Topics: Biochemistry, general

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