Overview
- Editors:
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Sidney M. Hect
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Department of Chemistry, Massachusetts Institute of Technology, Cambridge, USA
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Table of contents (32 papers)
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Synthetic and Biosynthetic Studies
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- Sidney M. Hecht, Donald J. Burlett, Yoshitaka Mushika, Yasuhisa. Kuroda, Mark D. Levin
Pages 48-62
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- Yoji Umezawa, Hajime Morishima, Takeo Yosioka, Masami Otsuka, Masaji Ohno
Pages 63-74
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Physical and Spectral Analysis of Bleomycin
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Bleomycin as a Metal Chelator
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- J. C. Dabrowiak, F. T. Greenway, F. S. Santillo
Pages 137-155
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Interaction of Bleomycin with DNA
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- Susan B. Horwitz, Edward A. Sausville, Jack Peisach
Pages 170-183
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- Masaru Takeshita, Arthur P. Grollman
Pages 207-221
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- Charles W. Haidle, R. Stephen Lloyd, Donald L. Robberson
Pages 222-243
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- James E. Strong, Stanley T. Crooke
Pages 244-254
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- Franklin Hutchinson, Lawrence F. Povirk
Pages 255-266
About this book
This book records the proceedings of a joint U.S.-Japan symposium on the chem istry, biochemistry, and biology of bleomycin, an antitumor antibiotic shown to be effective therapeutically against, eg, squamous cell carcinomas, Hodgkin's lymphoma, and testicular tumors. Several important and previously unreported observations were presented and the status of experimental work in the United States and Japan was reviewed; a summary and interpretation of the scientific presentations at the meeting has been prepared by the editor and is included as the first contribution in this volume. In addition to the symposium contributions, an experimental section has been included at the end of the book dealing with practical methods for the fractiona tion, modification, and assay of bleomycin. It is hoped that this section will facilitate progress in this area of scientific endeavor. The symposium from which this book is derived was organized by Drs. Umezawa, Takita, and Hecht and supported financially by the National Science Foundation, the National Cancer Institute, and the Japan Society for the Promotion of Science. S. M. Hecht v Contents Status Reports Summary of the Bleomycin Symposium. S. M. HECHT .............. 1 Advances in Bleomycin Studies. H. UMEZAWA ................... , 24 Review of the Structural Studies on Bleomycin. T. TAKITA . . . . . . . .. . . 37 . Synthetic and Biosynthetic Studies Studies on the Total Synthesis of Bleomycin. S. M. HECHT, D. 1. BURLETT, Y. MUSHIKA, Y. KURODA, and M. D. LEVIN .......... 48 A Synthetic Approach to the Pyrimidine Moiety of Bleomycin.
Editors and Affiliations
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Department of Chemistry, Massachusetts Institute of Technology, Cambridge, USA
Sidney M. Hect