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Bleomycin: Chemical, Biochemical, and Biological Aspects

Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18–22, 1978

  • Conference proceedings
  • © 1979

Overview

Editors:
  1. Sidney M. Hect

    1. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, USA

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Table of contents (32 papers)

  1. Front Matter

    Pages N1-xi
    Download chapter PDF

  2. Status Reports

    1. Summary of the Bleomycin Symposium

      • Sidney M. Hect
      Pages 1-23

    2. Advances in Bleomycin Studies

      • Hamao Umezawa
      Pages 24-36

    3. Review of the Structural Studies on Bleomycin

      • Tomahisa Takita
      Pages 37-47

  3. Synthetic and Biosynthetic Studies

    1. Studies on the Total Synthesis of Bleomycin

      • Sidney M. Hecht, Donald J. Burlett, Yoshitaka Mushika, Yasuhisa. Kuroda, Mark D. Levin
      Pages 48-62

    2. A Synthetic Approach to the Pyrimidine Moiety of Bleomycin

      • Yoji Umezawa, Hajime Morishima, Takeo Yosioka, Masami Otsuka, Masaji Ohno
      Pages 63-74

    3. Biogenetic Aspects of Bleomycin-Phleomycin Group Antibiotics

      • Akio Fujii
      Pages 75-91

  4. Physical and Spectral Analysis of Bleomycin

    1. Liquid Chromatography of Bleomycin

      • Yasuhiko Muraoka
      Pages 92-105

    2. NMR Study of Bleomycin

      • Hiroshi Naganawa
      Pages 106-123

  5. Bleomycin as a Metal Chelator

    1. 1H-NMR Study of the Metal-Binding Sites of Bleomycin

      • Norman J. Oppenheimer
      Pages 124-136

    2. The Metallobleomycins

      • J. C. Dabrowiak, F. T. Greenway, F. S. Santillo
      Pages 137-155

    3. Metal Complex of Bleomycin and Its Implication for the Mechanism of Bleomycin Action

      • Tomahisa Takita
      Pages 156-164

    4. Electron Spin Resonance Studies of 1:1:1 Bleomycin-Cobalt(II)-Qxygen Adduct Complex

      • Yukio Sugiura
      Pages 165-169

  6. Interaction of Bleomycin with DNA

    1. A Role for Iron in the Degradation of DNA by Bleomycin

      • Susan B. Horwitz, Edward A. Sausville, Jack Peisach
      Pages 170-183

    2. Contribution of the Superoxide Anion-Hydroxyl Radical Pathway to the Cleavage of DNA by Bleomycin

      • J. William Lown
      Pages 184-194

    3. Interaction of Bleomycin with DNA

      • Makoto Hori
      Pages 195-206

    4. A Molecular Basis for the Interaction of Bleomycin with DNA

      • Masaru Takeshita, Arthur P. Grollman
      Pages 207-221

    5. Molecular Aspects of Bleomycin-Promoted Damage of Covalently Closed Circular DNA

      • Charles W. Haidle, R. Stephen Lloyd, Donald L. Robberson
      Pages 222-243

    6. The Use of Covalently Closed Circular DNA to Investigate Properties of Bleomycin and Its Analogs

      • James E. Strong, Stanley T. Crooke
      Pages 244-254

    7. The Action of Bleomycin on DNA

      • Franklin Hutchinson, Lawrence F. Povirk
      Pages 255-266
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Keywords

About this book

This book records the proceedings of a joint U.S.-Japan symposium on the chem­ istry, biochemistry, and biology of bleomycin, an antitumor antibiotic shown to be effective therapeutically against, eg, squamous cell carcinomas, Hodgkin's lymphoma, and testicular tumors. Several important and previously unreported observations were presented and the status of experimental work in the United States and Japan was reviewed; a summary and interpretation of the scientific presentations at the meeting has been prepared by the editor and is included as the first contribution in this volume. In addition to the symposium contributions, an experimental section has been included at the end of the book dealing with practical methods for the fractiona­ tion, modification, and assay of bleomycin. It is hoped that this section will facilitate progress in this area of scientific endeavor. The symposium from which this book is derived was organized by Drs. Umezawa, Takita, and Hecht and supported financially by the National Science Foundation, the National Cancer Institute, and the Japan Society for the Promotion of Science. S. M. Hecht v Contents Status Reports Summary of the Bleomycin Symposium. S. M. HECHT .............. 1 Advances in Bleomycin Studies. H. UMEZAWA ................... , 24 Review of the Structural Studies on Bleomycin. T. TAKITA . . . . . . . .. . . 37 . Synthetic and Biosynthetic Studies Studies on the Total Synthesis of Bleomycin. S. M. HECHT, D. 1. BURLETT, Y. MUSHIKA, Y. KURODA, and M. D. LEVIN .......... 48 A Synthetic Approach to the Pyrimidine Moiety of Bleomycin.

Editors and Affiliations

  • Department of Chemistry, Massachusetts Institute of Technology, Cambridge, USA

    Sidney M. Hect

Bibliographic Information

  • Book Title: Bleomycin: Chemical, Biochemical, and Biological Aspects

  • Book Subtitle: Proceedings of a joint U.S.-Japan Symposium held at the East-West Center, Honolulu, July 18–22, 1978

  • Editors: Sidney M. Hect

  • DOI: https://doi.org/10.1007/978-1-4612-6191-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York Inc. 1979

  • Softcover ISBN: 978-1-4612-6193-3Published: 12 October 2011

  • eBook ISBN: 978-1-4612-6191-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 351

  • Topics: Medicine/Public Health, general, Analytical Chemistry, Biochemistry, general, Pharmacology/Toxicology

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