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Short-Term Tests for Chemical Carcinogens

  • Conference proceedings
  • © 1981

Overview

Editors:
  1. H. F. Stich

    1. Environmental Carcinogenesis Unit, British Columbia Cancer Research Centre, Vancouver, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. R. H. C. San

    1. Carcinogen Testing Laboratory, British Columbia Cancer Research Centre, Vancouver, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Topics in Environmental Physiology and Medicine (TEPHY)

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Table of contents (44 papers)

  1. Front Matter

    Pages i-xviii
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  2. Viral Systems

    1. A Biochemical Phage Induction Assay for Carcinogens

      • Rosalie K. Elespuru
      Pages 1-11

    2. Detection of DNA-Modifying Agents by Analyzing the Lesions Introduced into Purified PM2 DNA

      • Urs Kuhnlein, Siu Sing Tsang, Jane Edwards
      Pages 12-19

    3. Reactivation of Viruses

      • Andrew J. Rainbow
      Pages 20-35

  3. DNA

    1. Metabolic Activation of Nitroheterocyclic Compounds in Bacteria and Mammalian Cells

      • D. R. McCalla
      Pages 36-47

    2. Utilization of the Alkaline Elution Assay as a Short-Term Test for Chemical Carcinogens

      • James A. Swenberg
      Pages 48-58

    3. DNA Synthesis Inhibition in Mammalian Cells as a Test for Mutagenic Carcinogens

      • Robert B. Painter
      Pages 59-64

    4. DNA Repair Synthesis (UDS) as an in vitro and in vivo Bioassay to Detect Precarcinogens, Ultimate Carcinogens, and Organotropic Carcinogens

      • Hans F. Stich, Richard H. C. San, Hugh J. Freeman
      Pages 65-82

    5. Multi-well Assay for Unscheduled DNA Synthesis Using Human Diploid Fibroblasts

      • George R. Douglas, Caroline E. Grant, Judith M. Wytsma, Anthony Chan
      Pages 83-89

    6. Sucrose Gradients: An Assay for DNA Damage

      • B. Palcic, L. D. Skarsgard
      Pages 90-93

    7. The Testicular DNA-Synthesis Inhibition Test (DSI Test)

      • J. P. Seiler
      Pages 94-107

  4. Microbial Systems

    1. The Salmonella Mutagenicity Test: An Overview

      • Lynne Haroun, Bruce N. Ames
      Pages 108-119

    2. Applications of the Salmonella/Microsome Assay

      • Vincent F. Simmon
      Pages 120-126

    3. Determination of Genotoxic Activity Using DNA Polymerase-Deficient and -Proficient E. coli

      • Zev Leifer, Julie Hyman, Herbert S. Rosenkranz
      Pages 127-139

    4. The Nucleotide-Permeable Escherichia coli: A Model System that Responds to DNA-Binding Carcinogens, Mutagens, and Antitumor Agents with DNA Excision Repair or with Inhibition of Replicative DNA Synthesis

      • Heinz Walter Thielmann
      Pages 140-160

    5. The Yeast Saccharomyces cerevisiae: An Assay Organism for Environmental Mutagens

      • R. C. von Borstel
      Pages 161-170

    6. Induction and Genetic Characterization of Specific Locus Mutations in the ad-3 Region in Two-Component Heterokaryons of Neurospora crassa

      • Frederick J. de Serres
      Pages 175-186

    7. Neurospora and Environmentally Induced Aneuploidy

      • A. J. F. Griffiths
      Pages 187-199

  5. Higher Plants

    1. Plant Genetic Test Systems for the Detection of Chemical Mutagens

      • William F. Grant, A. E. Zinov’eva-Stahevitch, K. D. Zura
      Pages 200-216

  6. Chromosomes

    1. A Short-Term Cytogenetic Test for Genetic Instability in Humans

      • T. C. Hsu, William W. Au, Louise C. Strong, Dennis A. Johnston
      Pages 217-235
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Keywords

About this book

The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be­ tween the carcinogenicity and mutagenicity of chemicals and physical agents and by the assumption that DNA alteration, mutations, and chromosome aberrations are somehow involved in neoplastic transformation. Moreover, it has been tacitly assumed that the mutagenic capacity alone of compounds would induce regulatory agencies to pass rules for their removal from the environment and would lead the public to avoid them. The actual response, however, is quite different. Governmental departments shy away from making any decisions on the basis of in vitro test systems. The public at large is becoming irritated by daily an­ nouncements that many of their cherished habits could adversely affect their health. Industry appears to feel threatened and may reduce its search for new beneficial chemicals. The reluctance to accept wholeheartedly the mutagenicity tests for the detection of carcinogens is partly due to uncertainty about the in­ volvement of mutations in neoplastic transformation, partly due to the present difficulty of extrapolating results from various endpoints obtained on numerous organisms to man, and partly due to a multitude of complex events that lead in vivo to the evolvement of benign or malignant tumors.

Editors and Affiliations

  • Environmental Carcinogenesis Unit, British Columbia Cancer Research Centre, Vancouver, Canada

    H. F. Stich

  • Carcinogen Testing Laboratory, British Columbia Cancer Research Centre, Vancouver, Canada

    R. H. C. San

Bibliographic Information

  • Book Title: Short-Term Tests for Chemical Carcinogens

  • Editors: H. F. Stich, R. H. C. San

  • Series Title: Topics in Environmental Physiology and Medicine

  • DOI: https://doi.org/10.1007/978-1-4612-5847-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York Inc. 1981

  • Softcover ISBN: 978-1-4612-5849-0Published: 08 October 2011

  • eBook ISBN: 978-1-4612-5847-6Published: 06 December 2012

  • Series ISSN: 0172-6048

  • Edition Number: 1

  • Number of Pages: 518

  • Topics: Human Physiology, Oncology, Biochemistry, general

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