Inflammatory Diseases and Copper

1. Front Matter

   Pages i-xxi

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2. Physiological Aspects of Copper Metabolism

   1. Introduction to the Session on Physiological Aspects of Copper Metabolism

      • Walter Mertz

      Pages 1-1

   2. Copper Homeostasis

      • Gary W. Evans, W. Thomas Johnson

      Pages 3-15

   3. Estrogen Modulation of Blood Copper and Other Essential Metal Concentrations

      • Arthur Flynn

      Pages 17-30

   4. The Role of Leukocyte Endogenous Mediator (Endogenous Pyrogen) in Inflammation

      • Michael C. Powanda

      Pages 31-43

   5. Computer Analysis of Low Molecular Weight Copper Complexes in Biofluids

      • David R. Williams, C. Furnival, Peter M. May

      Pages 45-59

   6. Ceruloplasmin: Experimental Anti-Inflammatory Activity and Physicochemical Properties

      • M. J. Laroche, P. Chappuis, Y. Henry, F. Rousselet

      Pages 61-72

3. Physiological Aspects of Copper Metabolism

   1. Introduction to the Afternoon Session on Physiological Aspectes of Copper Metabolism

      • Wolfgang Forth

      Pages 73-74

   2. Wilson’s Disease

      • Irmin Sternlieb

      Pages 75-84

   3. Copper Metabolism in Menkes’ Syndrome and Mottled Mouse Mutants

      • J. Camakaris, D. M. Danks, M. Phillips, S. Herd, J. R. Mann

      Pages 85-96

   4. Intestinal Content of the Copper-Binding Protein in Brindled, Blotchy and Crinkled Mice and Cellular Copper Transport

      • J. H. Lipton, F. Bronner

      Pages 97-107

   5. Teratogenic Effects of Copper Deficiency and Excess

      • Carl L. Keen, Bo Lönnerdal, Lucille S. Hurley

      Pages 109-121

   6. An Appraisal of Current Human Copper Nutriture

      • Leslie M. Klevay

      Pages 123-136

   7. Environmental Metal Ion Perturbations, Especially as They Affect Copper Status, are a Factor in the Etiology of Arthritic Conditions: An Hypothesis

      • K. D. Rainsford

      Pages 137-143

4. Biochemical Aspects of Copper Metabolism

   1. Introduction to the Session on Biochemical Aspects of Copper Metabolism

      • John T. McCall

      Pages 145-145

   2. Hormonal Regulation of Copper and Zinc Metabolism in Isolated Rat Liver Parenchymal Cells

      • Robert J. Cousins, Alan L. Weiner

      Pages 147-157

   3. Ceruloplasmin: A Multi-Functional Cupro-Protein of Vertebrate Plasma

      • Earl Frieden

      Pages 159-169

   4. Comparison of the Catalytic Activities of Mammalian Ceruloplasmins

      • A. Zgirski, M. V. Chidambaram, E. Frieden

      Pages 171-181

   5. Lysyl Oxidase, a Molecular Target of Copper

      • Edward D. Harris, Robert A. DiSilvestro, James E. Balthrop

      Pages 183-198

   6. Cu-Zn Superoxide Dismutase

      • Garry R. Buettner

      Pages 199-207

In 1928, it was discovered that copper was essential for normal human metabolism. A decade later, in 1938, it was observed that patients with rheu­ matoid arthritis exhibited a higher than normal serum copper concentration that returned to normal with remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic dis­ eases. The first report that copper complexes had antiinflammatory activity in an animal model of inflammation appeared twenty-two years after the dis­ covery of essentiality. In 1976, it was suggested that the active forms of the antiarthritic drugs are their copper complexes formed in vivo. This sugges­ tion has been confirmed and extended in the interim in over 200 recent publications. Individual biomedical scientists from many countries who have published in these areas recently saw a need for a meeting to exchange current re­ supporting new hypotheses. We search results and discuss the evidence met on the University of Arkansas Medical Sciences campus in Little Rock, Arkansas, August 10-13, 1981. Participants came from Australia, England, France, Germany, Israel, Italy, The Netherlands, Norway, Poland, Scotland, Sweden, Switzerland, Wales, Zimbabwe, and over twenty of the United States.

• Amino acid
• Arthritis
• Lipid
• Oxidation
• inflammation
• metabolism
• protein
• rheumatic diseases
• rheumatoid arthritis

• Department of Biopharmaceutical Sciences, College of Pharmacy and Department of Pharmacology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, USA

  John R. J. Sorenson

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