Overview
- Editors:
-
-
Stewart Sell
-
University of California, San Diego, USA
-
Britta Wahren
-
Karolinska Hospital, Stockholm, Sweden
Access this book
Other ways to access
Table of contents (16 chapters)
-
-
-
- Robert Fox, Stephen Baird, Patrick Kung, Ron Levy, Ivor Royston
Pages 33-68
-
- D. R. Galloway, R. A. Reisfeld
Pages 69-88
-
-
- Hans O. Sjögren, Britta Wahren
Pages 105-132
-
-
-
- T. Ming Chu, Ming C. Wang, Ching-li Lee, Carl S. Killian, Manabu Kuriyama, Lawrence D. Papsidero et al.
Pages 179-190
-
- Thomas S. Edgington, Robert M. Nakamura
Pages 191-232
-
-
-
- Torgny Stigbrand, Eva Engvall
Pages 275-301
-
- Britta Wahren, Peter Perlmann
Pages 303-319
-
- Geoffrey Mendelsohn, Stephen B. Baylin
Pages 321-358
-
-
- Trevor R. Jones, Darell D. Bigner
Pages 381-422
-
Back Matter
Pages 423-428
About this book
The ability to diagnose cancer by simple measurement of a serum or tissue' 'marker" has been a goal of medical science for many years. There is ample evidence that tumor cells are different from normal cells and pro duce substances that can be detected by currently available immuno chemical or biochemical methods. These "cancer markers" may be se creted proteins, enzymes, hormones, fetal serum components, monoclonal immunoglobulins, cell surface components, or cytoplasmic constituents. The purpose of this book is to present the current status of our knowledge of such cancer markers. The first tumor marker identified by laboratory means was Bence Jones protein. In a series of lectures delivered to the Royal College of Phy sicians in London in 1846, Dr. H. Bence Jones described studies on a urine sample sent to him with the following note: "Dear Dr. Jones-The tube contains urine of very high specific gravity. When boiled it becomes slightly opaque . . . . etc. " Dr. Jones found that heating of the urine after addition of nitric acid resulted in formation of a heavy precipitate; acid ad dition may have been required to bring the urine to pH 4-6 at which Bence Jones proteins are more likely to precipitate when heated. This urinary pre cipitate was associated with a bone disease termed "mollities ossium. " [H. Bence Jones, Papers on Chemical Pathology, Lecture III. Lancet 2, 269-274 (1847)].
Editors and Affiliations
-
University of California, San Diego, USA
Stewart Sell
-
Karolinska Hospital, Stockholm, Sweden
Britta Wahren
