Ir Genes

1. Front Matter

   Pages i-xxvi

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2. Genetic Organization of I-Region Genes

   1. Front Matter

      Pages 1-1

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   2. Ia Genes, Gene Products, and Determinants

      • Chella S. David, William P. Lafuse

      Pages 3-12

   3. Murine T Cell-Specific IA Antigens: Helper T Lymphocytes Express a Unique I-A-Encoded Molecule

      • Colleen E. Hayes, Robert M. Whitcomb, David P. Krum, Karen K. Klyczek, Debra A. Hullett

      Pages 13-17

   4. Definition of New Ia+ T Cell Subsets

      • Mauro S. Sandrin, Jenni S. Craig, Ian F. C. McKenzie

      Pages 19-22

   5. Antibody and T Cell Recognition of Select Ia Determinants Using the I-A Mutant B6.C-H-2 ^bm12

      • William Walsh, Frances Pappas, Regina Skelly, Ted Hansen

      Pages 23-28

   6. Induction of Autoreactive T Cells by Stimulation Across the I-J Subregion

      • Mark C. Horowitz, Donal B. Murphy

      Pages 29-38

   7. Enhancement of Murine T Cell I-J Expression by Limited Proteolysis

      • Karen Klyczek, Debra Hullett, Colleen Hayes

      Pages 39-43

   8. Isolation and Analysis of Subpopulations of I-Ab Molecules with Monoclonal Antibodies

      • William Lafuse, Michel Pierres, Chella S. David

      Pages 45-49

   9. Partial Characterization of 8 Anti-I-J and 3 Anti-Ia Monoclonal Reagents

      • V. Hauptfeld, M. Hauptfeld, M. Nahm, J. Trial, J. Kapp, D. Shreffler

      Pages 51-55

   10. Interspecies Cross Reactivity of Monoclonal Anti-I-E Antibodies Specific for Polymorphic Ia Determinants

       • J. K. Lunney, B. A. Osborne, C. Devaux, M. Pierres, D. H. Sachs

       Pages 57-61

   11. Structural Characterization of I-Ab Subsets Using Monoclonal Antibodies

       • Sujay K. Singh, William P. Lafuse, David J. McKean, Chella S. David

       Pages 63-67

   12. Factor-Mediated Regulation of the Expression of the H-2 Linked Low Molecular Weight Proteins (LMP)

       • John J. Monaco, Grace Ku, Hugh O. McDevitt

       Pages 69-73

   13. Quantitation of Ia Antigens on Normal and Leukemic Human Lymphocytes

       • Michelle Letarte, Jun Okamura, Jane B. L. Addis, Roland Tisch, Erwin W. Gelfand

       Pages 75-79

   14. Use of Monoclonal Antibodies for Studies of Anti-Ia Receptor Idiotypes

       • Suzanne L. Epstein, David H. Sachs

       Pages 81-90

   15. A Recombinatorial Event Separating the Immune Response Genes for LDH-B and MOPC-173: Implications for a New Model of I Region Gene Organization

       • David H. Gutmann, Paul M. Allen, John E. Niederhuber

       Pages 91-95

   16. Expression of Ia Antigens and Ir Gene Function During Differentiation of Bone Marrow Derived Macrophage

       • L. B. Schook, D. H. Gutmann, L. E. Marlin, J. E. Niederhuber

       Pages 97-101

   17. The IR-THY-1 Genes: Possible Mechanism of Their Effect

       • J. S. Reichner, M. B. Zaleski

       Pages 103-107

   18. Complementing IR-Genes Located in the I-A Subregion and between the S and D Regions are Required for the Response to TNP-Ficoll

       • Linda M. Hillstrom, John E. Niederhuber

       Pages 109-113

3. Chemistry of I-Region Gene Products and DNA Cloning of I-Region Gene Products

   1. Front Matter

      Pages 115-115

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The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man­ uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad­ dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob­ servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog­ ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev­ eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.

• Antigen
• DNA
• Macrophages
• Monoclonal Antibodies
• T cell
• Vivo
• cell
• development
• gene
• genes
• genetics
• immune response
• immunity
• mutant
• regulation

• Department of Pathology and Laboratory Medicine, The Jewish Hospital of St. Louis, St. Louis, USA

  Carl W. Pierce, Judith A. Kapp

• Department of Microbiology and Immunology, Washington University, St. Louis, USA

  Susan E. Cullen

• Howard Hughes Medical Institute Laboratory and the Departments of Medicine (Div. of Rheumatology) and Microbiology and Immunology, Washington University School of Medicine, St. Louis, USA

  Benjamin D. Schwartz

• Department of Genetics, Washington University School of Medicine, St. Louis, USA

  Donald C. Shreffler

Policies and ethics