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Directed Drug Delivery

A Multidisciplinary Problem

  • Book
  • © 1985

Overview

Editors:
  1. Ronald T. Borchardt

    1. University of Kansas, Lawrence, USA

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  2. Arnold J. Repta

    1. University of Kansas, Lawrence, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Valentino J. Stella

    1. University of Kansas, Lawrence, USA

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Part of the book series: Experimental Biology and Medicine (EBAM, volume 7)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xv
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  2. Pharmacodynamic and Pharmacokinetic Factors Influencing Directed Drug Delivery

    1. Front Matter

      Pages 1-1
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    2. Pharmaceutics and the Evolving Technology of Drug Delivery-A Perspective

      • Joseph R. Robinson
      Pages 3-12

    3. Pharmacodynamic Considerations in the Development of New Drug Delivery Concepts

      • Bobbe L. Ferraiolo, Leslie Z. Benet
      Pages 13-33

    4. Molecular Mechanisms of Drug Action and Pharmacokinetic-Pharmacodynamic Models

      • Wolfgang Sadée
      Pages 35-49

    5. The Therapeutic System: Therapeutic Implications of Rate-Controlled Drug Delivery

      • John Urquhart
      Pages 51-58

  3. Physiological and Biochemical Factors Influencing Directed Drug Delivery

    1. Front Matter

      Pages 59-59
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    2. Gastrointestinal Barrier to Oral Drug Delivery

      • Colin R. Gardner
      Pages 61-82

    3. Strategies for Drug Delivery through the Blood-Brain Barrier

      • William M. Pardridge
      Pages 83-96

    4. The Dermal Barrier to Local and Systemic Drug Delivery

      • W. I. Higuchi, J. L. Fox, K. Knutson, B. D. Anderson, G. L. Flynn
      Pages 97-117

  4. Physical-Chemical Approaches to Directed Drug Delivery

    1. Front Matter

      Pages 119-119
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    2. A Physical Approach to Drug Delivery

      • Felix Theeuwes
      Pages 121-146

    3. Microparticulate Drug Carriers

      • R. L. Juliano
      Pages 147-170

    4. Biodegradable Poly(Ortho Esters) as Drug Delivery Forms

      • J. Heller, K. J. Himmelstein
      Pages 171-188

    5. Macromolecules as Drug Delivery Systems

      • Hitoshi Sezaki, Mitsuru Hashida
      Pages 189-208

  5. Biological-Chemical Approaches to Directed Drug Delivery

    1. Front Matter

      Pages 209-209
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    2. Monoclonal Antibody Mediated Drug Delivery and Antibody Toxin Conjugates

      • David M. Neville Jr.
      Pages 211-230

    3. Drug Delivery via Cell-Surface Receptors

      • T. Y. Shen
      Pages 231-245

    4. Prodrugs: A Chemical Approach to Targeted Drug Delivery

      • Valentino J. Stella, Kenneth J. Himmelstein
      Pages 247-267

    5. New Drug Delivery Systems: Physico-Chemical Considerations

      • Ian H. Pitman
      Pages 269-288
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Keywords

About this book

This book is based on the proceedings of the symposium entitled "Di­ rected Drug Delivery: A Multidisciplinary Problem," which was held in Lawrence, Kansas on October 17-19, 1984. The purpose of the sym­ posium and this book is to focus on the multidisciplinary nature of drug delivery. Development of a successful drug delivery system re­ quires contributions from various scientific disciplines, including pharmaceutical chemistry, analytical chemistry, medicinal chemistry, biochemistry, pharmacology, toxicology, and clinical medicine. The contents of this volume illustrate the importance of the various disci­ plines in identifying the problems and approaches for the develop­ ment of a rational and effective drug delivery system. Thus the infor­ mation provided herein will be of value not only to the pharmaceutical chemists who are responsible for dosage form design, but also to the pharmacokineticists, pharmacologists, and clinicians involved in bio­ logical evaluation of drug delivery systems. The volume should also be of interest to the analytical chemists who must provide technology to quantitcltively evaluate drug delivery. Additionally, this work will also interest the biochemists and medicinal chemists involved in drug dis­ covery, since the drug delivery system often plays a major role in determining the success or failure of a new drug entity. Each speaker at the symposium was requested to contribute a chapter reviewing the contribution of their major discipline to the de­ velopment of a successful drug delivery system.

Editors and Affiliations

  • University of Kansas, Lawrence, USA

    Ronald T. Borchardt, Arnold J. Repta, Valentino J. Stella

Bibliographic Information

  • Book Title: Directed Drug Delivery

  • Book Subtitle: A Multidisciplinary Problem

  • Editors: Ronald T. Borchardt, Arnold J. Repta, Valentino J. Stella

  • Series Title: Experimental Biology and Medicine

  • DOI: https://doi.org/10.1007/978-1-4612-5186-6

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Humana Press Inc. 1985

  • Hardcover ISBN: 978-0-89603-089-3Published: 13 August 1985

  • Softcover ISBN: 978-1-4612-9603-4Published: 05 October 2011

  • eBook ISBN: 978-1-4612-5186-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVI, 368

  • Topics: Pharmacy, Pharmacology/Toxicology

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