Overview
- Editors:
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Marc Feldmann
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Andrew McMichael
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Table of contents (34 chapters)
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Front Matter
Pages i-xiii
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Molecular Basis of MHC
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- Pila Estess, Ann B. Begovich, Patricia P. Jones, Hugh O. McDevitt
Pages 3-19
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- Bernard Mach, Claude de Préval, Pierre Rollini, Jack Gorski
Pages 43-49
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- Dominique J. Charron, Alain Haziot, Vincent Lotteau, Dominique Neel, Benoit Merlu, Luc Teyton
Pages 61-72
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Molecular Basis of Lymphocyte Activation
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- C. Terhorst, K. Georgopoulos, P. Gold, H. Oettgen, C. Pettey, D. Ucker et al.
Pages 75-84
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- Katsushige Hasegawa, Mitsuo Maruyama, Takashi Fujita, Tetsuo Ohashi, Masanori Hatakeyama, Seijiro Minamoto et al.
Pages 85-93
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- Robert F. Siliciano, Ellis L. Reinherz
Pages 95-110
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- Suzanne Pont, Anne Regnier-Vigouroux, Philippe Naquet, Michel Pierres
Pages 111-117
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- D. A. Cantrell, A. A. Davies, G. Krissansen, M. J. Crumpton
Pages 119-133
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Molecular Analysis of T Cell Receptors
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Front Matter
Pages 135-135
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- M. M. Davis, C. Goodnow, N. R. J. Gascoigne, T. Lindsten, Y. Chien
Pages 137-142
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- M. J. Owen, M. K. L. Collins, A.-M. Kissonerghis, M. J. Dunne, S. John
Pages 143-153
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- T. H. Rabbitts, R. Baer, K.-C. Chen, A. Forster, M.-P. Lefranc, S. Smith et al.
Pages 155-165
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- N. Shastri, J. Kobori, D. Munt, L. Hood
Pages 167-176
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- Marie Malissen, Candice McCoy, Dominique Blanc, Jeannine Trucy, Christian Devaux, Anne-Marie Schmitt-Verhulst et al.
Pages 177-183
About this book
This book encompasses the proceedings of a conference held at Trinity College, Oxford on September 21-25, 1985 organized by a committee comprised of Drs. M. Crumpton, M. Feldmann, A. McMichael, and E. Simpson, and advised by many friends and colleagues. The immune response gene workshops that took place were based on the need to understand why certain experimental animal strains were high responders and others were low responders. It was assumed that identification of the immune response (Ir) genes and definition of their products would explain high and low responder status. Research in the ensuing years has identified the Ir gene products involved in antibody responses as the la antigens, or MHC Class II antigens. These proteins are now well defined as members of the immunoglobulin gene superfamily, and their domain structure is known. Epitopes have been defined by multiple mono clonal antibodies and regions of hypervariability identified. Their genes have been identified and cloned. The basic observation of high and low responsive ness to antigen is still not understood in mechanistic terms, however, at either the cellular or molecular level. This is because the rate of progress in immune regulation has been far slower than in the molecular biology of the MHC Class II antigens. This is not surprising, since immune regulation is a very complex field at the crossroads of many disciplines.
