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International Symposium: Retroviruses and Human Pathology

  • Book
  • © 1985

Overview

Editors:
  1. Robert C. Gallo

    1. National Institutes of Health, Bethesda, USA

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  2. Dominique Stehelin

    1. Institut Pasteur, Lille, France

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  3. Oliviero E. Varnier

    1. Istituto di Microbiologia, University of Genova, Genova, Italia

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Part of the book series: Experimental Biology and Medicine (EBAM, volume 11)

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Table of contents (49 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Introduction: The Role of Retroviruses

    1. Front Matter

      Pages xxiii-xxiii
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    2. Opening Remarks

      • Carmine A. Romanzi
      Pages 1-1

    3. Retroviruses in Neoplasia Yesterday, Today and Tomorrow

      • N. Oker-Blom, S. Pfeifer-Ohlsson, K. Alitalo
      Pages 3-17

    4. The Role of Retroviruses in Nature

      • R. Dulbecco
      Pages 19-33

  3. W. P. Rowe Memorial Lecture

    1. Front Matter

      Pages 34-34
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    2. Changing Dogmas in Retrovirology

      • J. A. Levy
      Pages 35-59

  4. Retroviruses and the Murine Model System

    1. Front Matter

      Pages 61-61
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    2. The Biology of Endogenous Leukemia Viruses: A Study of the DBA/2 Mouse

      • B. A. Nexø
      Pages 63-76

    3. Murine Xenotropic Retroviruses: In the Computer Age

      • O. E. Varnier
      Pages 77-86

    4. Viral and Nonviral Mammary Tumorigenesis

      • J. Hilgers, A. Sonnenberg
      Pages 87-97

    5. The Proviral Genome of Radiation Leukemia Virus: Molecular Cloning, Nucleotide Sequence of Its Long Terminal Repeat and Integration in Lymphoma Cell DNA

      • M. Janowski, J. Merregaert, J. Boniver, J. R. Maisin
      Pages 99-109

    6. Metastatic Potential of Friend Leukemia Cells: Fibronectin Induces Specific Arrest, Survival and Growth of FLC in Liver of DBA/2 Mice

      • A. Benedetto, C. Amici, W. Djaczenko, S. Zaniratti, G. Elia
      Pages 111-121

    7. The Envelope Gene of Mammalian Retroviruses: Analysis of its Structure Reveals Specific Recombination Signals

      • R. Friedrich, W. Koch, B. Hackl, W. Zimmermann
      Pages 123-131

    8. The Major Histocompatibility Complex (H-2) of the Mouse Influences the Phenotype of Murine Leukemia Virus-Induced Lymphomas

      • W. L. E. Vasmel, M. Zijlstra, R. E. Y. De Goede, H. J. Schoenmakers, T. Radaszkiewics, C. J. M. Melief
      Pages 133-137

    9. Mouse Mammary Tumor Virus (MMTV) Morphology in the Gastrointestinal Lumen of Suckling Mice

      • G. Bevilacqua, A. Marchetti
      Pages 139-144

    10. Murine Retroviruses: An Alternative Screening Approach for Antiviral Drug Research

      • O. Muratore
      Pages 145-150

  5. Retroviruses and the Vertebrate Model System

    1. Front Matter

      Pages 151-151
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    2. Retroviruses and Oncogenes in Rats

      • S. Rasheed
      Pages 153-175

    3. Target Cells for Avian Leukemia Viruses Revisited

      • C. Moscovici
      Pages 177-191
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Keywords

About this book

For decades retroviruses have been riding the crest of a wave of experimental research directed toward the identification of an infectious agent of human neoplastic diseases. In the early 1970s, several scientists successfully demonstrated the presence of retroviruses in numerous animal species and proved their etiological role in some related diseases. Corresponding findings in humans were somewhat discouraging. Although financial support for this line· of research declined, a few dedicated retrovirologists survived and continued to collect more biological information and technological expertise that opened a new approach to the search for a human retrovirus. The rewards came with the discovery that the genes responsible for neoplastic transformation (oncogenes) are of cellular origin and can be shuttled about by retroviruses, and with the identification of a new family of Human T-cell Lymphotrophic retroViruses (HTLV) from patients with diseases ranging from leukemia to the acquired immunodeficiency syndrome (AIDS). An understanding of the role and significance of retroviruses in human pathology requires basic knowledge of the major animal systems studied. With this perspective in mind, we present here a survey that includes general overviews, minireviews on each animal system studied with selected experimental reports and, finally, a stimulating review of the field of human retrovirology by many of the pioneer scientists who created it. We are especially grateful to Profs. C. A. Romanzi and G. C. Schito for promoting the organization of the Symposium. On behalf of the Sym­ posium Committee, we thank E. Soeri, L. Casarino, G. P. Gesu, M.

Editors and Affiliations

  • National Institutes of Health, Bethesda, USA

    Robert C. Gallo

  • Institut Pasteur, Lille, France

    Dominique Stehelin

  • Istituto di Microbiologia, University of Genova, Genova, Italia

    Oliviero E. Varnier

Bibliographic Information

  • Book Title: International Symposium: Retroviruses and Human Pathology

  • Editors: Robert C. Gallo, Dominique Stehelin, Oliviero E. Varnier

  • Series Title: Experimental Biology and Medicine

  • DOI: https://doi.org/10.1007/978-1-4612-5008-1

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Humana Press Inc. 1985

  • Hardcover ISBN: 978-0-89603-098-5Published: 08 April 1986

  • Softcover ISBN: 978-1-4612-9396-5Published: 14 October 2011

  • eBook ISBN: 978-1-4612-5008-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXIV, 557

  • Topics: Immunology

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