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Vitamins and Cancer

Human Cancer Prevention by Vitamins and Micronutrients

  • Book
  • © 1986

Overview

Editors:
  1. Frank L. Meyskens

    1. Section of Hematology/Oncology, Cancer Center, Arizona Health Sciences Center, Tucson, USA

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  2. Kedar N. Prasad

    1. Center of Vitamins and Cancer Research Department of Radiology, University of Colorado Health Sciences Center, Denver, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Experimental Biology and Medicine (EBAM, volume 10)

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-xx
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  2. Basic Experimental Approaches

    1. Front Matter

      Pages 1-1
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    2. Studies on the Mechanism of the Antiproliferative Action of Retinoids Using Retinoid-Resistant Melanoma Cell Mutants

      • Reuben Lotan
      Pages 3-17

    3. Retinoids, Polyamines and Teratocarcinoma Differentiation

      • Joel Schindler, Michael Kelly
      Pages 19-33

    4. Biochemical Mechanism of Inhibition of Phorbol Ester-Induced Mouse Epidermal Ornithine Decarboxylase by Retinoic Acid

      • Ajit K. Verma
      Pages 35-49

    5. The Effects of Antioxidants on the Induction of Malignant Transformation in Vitro

      • Ann R. Kennedy
      Pages 51-64

    6. Free Radicals, Dietary Antioxidants and Mechanisms in Cancer Prevention; in Vitro Studies

      • Carmia Borek
      Pages 65-82

    7. Ascorbate Effects on Endomembrane Electron Transport and Membrane Flux

      • D. James Morré, Iris Sun, F. L. Crane
      Pages 83-92

    8. Modification of Tumor Cell Response in Vitro by Vitamin E

      • Kedar N. Prasad, Bhola N. Rama, Richard M. Detsch
      Pages 93-110

  3. Chemoprevention (Preclinical)

    1. Front Matter

      Pages 111-111
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    2. Nutrients and other Risk Factors Associated with Cancer

      • Paul M. Newberne, Thomas F. Schrager, Michael W. Conner
      Pages 113-138

    3. Supplemental Carotenoids Prevent Skin Cancer by Benzo(a)Pyrene, Breast Cancer by Puva, and Gastric Cancer by MNNG. Relevance in Human Chemoprevention

      • L. Santamaria, A. Bianchi, A. Arnaboldi, L. Andreoni, G. Santagati, C. Ravetto et al.
      Pages 139-159

    4. Retinoids as Chemopreventive Agents: Alone and in Combination

      • R. C. Moon, D. L. McCormick, R. G. Mehta
      Pages 161-180

    5. Dietary Cholesterol and Colon Tumorigenesis Induced by 1,2, Dimethylhydrazine or N-Methyl-N-Nitrosourea in Rats

      • Selwyn A. Broitman, Herbert Z. Kupchik, Leonard S. Gottlieb
      Pages 181-197

    6. Effects of Vitamin E on the Immune System

      • Mary P. Carpenter
      Pages 199-211

    7. Mechanism and Prevention of Anticancer Agent-Induced Cancer: Interactions of Vitamin E and Daunorubicin

      • Yeu-Ming Wang
      Pages 213-228

  4. Chemoprevention (Human)

    1. Front Matter

      Pages 229-229
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Keywords

About this book

In the past five years, a surprising and intense resurgence in interest in vitamins and other micronutrients and their role in health and dis­ ease has occurred. The recognition has emerged that vitamins not only are essential for life ·in that severe nutritional deficiencies occur in their absence, but that these compounds may also serve as natural inhibitors of cancer. Synthetic alterations of the basic vitamin A mole­ cule have also resulted in the production of compounds that are more potent as anticancer agents than the natural substance and may have substantial therapeutic activity as well. Whether other vita­ mins can be changed or altered to produce a better anticancer effect than the native compound has been little explored to date, but should be a fruitful pursuit for future study. In our concluding remarks to the First International Conference in 1982, we speculated that rapid advances in our understanding of vi­ tamins would occur in the next few years and that large-scale inter­ vention trials of vitamins as preventive agents in defined human pop­ ulations would be started. This anticipated generation of data on vitamins and their interactions has proceeded rapidly and the impor­ tance of interactions between vitamins and other micronutrients in the prevention setting has become better appreciated. Currently, more than 25 intervention trials with a variety of target populations using vitamins and other micronutrients have been started, but it re­ mains too early for meaningful analysis of the results to date.

Editors and Affiliations

  • Section of Hematology/Oncology, Cancer Center, Arizona Health Sciences Center, Tucson, USA

    Frank L. Meyskens

  • Center of Vitamins and Cancer Research Department of Radiology, University of Colorado Health Sciences Center, Denver, USA

    Kedar N. Prasad

Bibliographic Information

  • Book Title: Vitamins and Cancer

  • Book Subtitle: Human Cancer Prevention by Vitamins and Micronutrients

  • Editors: Frank L. Meyskens, Kedar N. Prasad

  • Series Title: Experimental Biology and Medicine

  • DOI: https://doi.org/10.1007/978-1-4612-5006-7

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Humana Press Inc. 1986

  • Hardcover ISBN: 978-0-89603-094-7Published: 25 February 1986

  • Softcover ISBN: 978-1-4612-9395-8Published: 04 February 2012

  • eBook ISBN: 978-1-4612-5006-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XX, 482

  • Topics: Oncology

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