Vitamins and Cancer

1. Front Matter

   Pages i-xx

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2. Basic Experimental Approaches

   1. Front Matter

      Pages 1-1

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   2. Studies on the Mechanism of the Antiproliferative Action of Retinoids Using Retinoid-Resistant Melanoma Cell Mutants

      • Reuben Lotan

      Pages 3-17

   3. Retinoids, Polyamines and Teratocarcinoma Differentiation

      • Joel Schindler, Michael Kelly

      Pages 19-33

   4. Biochemical Mechanism of Inhibition of Phorbol Ester-Induced Mouse Epidermal Ornithine Decarboxylase by Retinoic Acid

      • Ajit K. Verma

      Pages 35-49

   5. The Effects of Antioxidants on the Induction of Malignant Transformation in Vitro

      • Ann R. Kennedy

      Pages 51-64

   6. Free Radicals, Dietary Antioxidants and Mechanisms in Cancer Prevention; in Vitro Studies

      • Carmia Borek

      Pages 65-82

   7. Ascorbate Effects on Endomembrane Electron Transport and Membrane Flux

      • D. James Morré, Iris Sun, F. L. Crane

      Pages 83-92

   8. Modification of Tumor Cell Response in Vitro by Vitamin E

      • Kedar N. Prasad, Bhola N. Rama, Richard M. Detsch

      Pages 93-110

3. Chemoprevention (Preclinical)

   1. Front Matter

      Pages 111-111

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   2. Nutrients and other Risk Factors Associated with Cancer

      • Paul M. Newberne, Thomas F. Schrager, Michael W. Conner

      Pages 113-138

   3. Supplemental Carotenoids Prevent Skin Cancer by Benzo(a)Pyrene, Breast Cancer by Puva, and Gastric Cancer by MNNG. Relevance in Human Chemoprevention

      • L. Santamaria, A. Bianchi, A. Arnaboldi, L. Andreoni, G. Santagati, C. Ravetto et al.

      Pages 139-159

   4. Retinoids as Chemopreventive Agents: Alone and in Combination

      • R. C. Moon, D. L. McCormick, R. G. Mehta

      Pages 161-180

   5. Dietary Cholesterol and Colon Tumorigenesis Induced by 1,2, Dimethylhydrazine or N-Methyl-N-Nitrosourea in Rats

      • Selwyn A. Broitman, Herbert Z. Kupchik, Leonard S. Gottlieb

      Pages 181-197

   6. Effects of Vitamin E on the Immune System

      • Mary P. Carpenter

      Pages 199-211

   7. Mechanism and Prevention of Anticancer Agent-Induced Cancer: Interactions of Vitamin E and Daunorubicin

      • Yeu-Ming Wang

      Pages 213-228

4. Chemoprevention (Human)

   1. Front Matter

      Pages 229-229

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   2. Methodological Issues

      1. A New HPLC Method for the Simultaneous Analysis of Plasma Retinol, Tocopherols, and Carotenoids and its Application in Cancer Epidemiology

         • Chung S. Yang, Kenneth W. Miller, Mao-Jung Lee

         Pages 231-243

      2. Clinical Toxicology Pharmacokinetics of 13-Cis-Retinoic Acid Administered Chronically at Low Doses Expected for Cancer Chemoprevention Trials

         • David S. Alberts, Libby Edwards, Yei-Mei Peng, Ruth Serokman, Thomas P. Davis, Frank L. Meyskens Jr.

         Pages 245-255

      3. Changing the Public’s Health Behaviors by Diet and Chemopreventive Interventions

         • Curtis Mettlin

         Pages 257-266

In the past five years, a surprising and intense resurgence in interest in vitamins and other micronutrients and their role in health and dis­ ease has occurred. The recognition has emerged that vitamins not only are essential for life ·in that severe nutritional deficiencies occur in their absence, but that these compounds may also serve as natural inhibitors of cancer. Synthetic alterations of the basic vitamin A mole­ cule have also resulted in the production of compounds that are more potent as anticancer agents than the natural substance and may have substantial therapeutic activity as well. Whether other vita­ mins can be changed or altered to produce a better anticancer effect than the native compound has been little explored to date, but should be a fruitful pursuit for future study. In our concluding remarks to the First International Conference in 1982, we speculated that rapid advances in our understanding of vi­ tamins would occur in the next few years and that large-scale inter­ vention trials of vitamins as preventive agents in defined human pop­ ulations would be started. This anticipated generation of data on vitamins and their interactions has proceeded rapidly and the impor­ tance of interactions between vitamins and other micronutrients in the prevention setting has become better appreciated. Currently, more than 25 intervention trials with a variety of target populations using vitamins and other micronutrients have been started, but it re­ mains too early for meaningful analysis of the results to date.

• cancer prevention
• carcinoma
• cell
• clinical trial
• gastric cancer
• melanoma
• prevention
• tumor
• tumorigenesis

• Section of Hematology/Oncology, Cancer Center, Arizona Health Sciences Center, Tucson, USA

  Frank L. Meyskens

• Center of Vitamins and Cancer Research Department of Radiology, University of Colorado Health Sciences Center, Denver, USA

  Kedar N. Prasad

Policies and ethics